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Long term outcomes after perioperative treatment with n-3 fatty acid supplements in colorectal cancer

Long term outcomes after perioperative treatment with n-3 fatty acid supplements in colorectal cancer
Long term outcomes after perioperative treatment with n-3 fatty acid supplements in colorectal cancer
Background
This study aimed to evaluate the effect of perioperative supplementation with omega‐3 fatty acids (n ‐3 FA) on perioperative outcomes and survival in patients undergoing colorectal cancer surgery.

Methods
Patients scheduled for elective resection of colorectal cancer between 2007 and 2010 were randomized to either an n ‐3 FA‐enriched oral nutrition supplement (ONS) twice daily or a standard ONS (control) for 7 days before and after surgery. Outcome measures, including postoperative complications, 3‐year cumulative incidence of local or metastatic colorectal cancer recurrence and 5‐year overall survival, were compared between the groups.

Results
Of 148 patients enrolled in the study, 125 (65 patients receiving n ‐3 FA‐enriched ONS and 60 receiving standard ONS) were analysed. There were no differences in postoperative complications after surgery (P = 0·544). The risk of disease recurrence at 3 years was similar (relative risk 1·66, 95 per cent c.i. 0·65 to 4·26).The 5‐year survival rate of patients treated with n ‐3 FA was 69·2 (95 per cent c.i. 56·5 to 78·9) per cent, compared with 81·7 (69·3 to 89·4) per cent in the control group (P = 0·193). After adjustment for age, stage of disease and adjuvant chemotherapy, n ‐3 FA was associated with higher mortality compared with controls (hazard ratio 1·73, 95 per cent c.i. 1·06 to 2·83; P = 0·029). The interaction between n ‐3 FA and adjuvant chemotherapy was not statistically significant.

Conclusion
Perioperative supplementation with n ‐3 FA did not confer a survival benefit in patients undergoing colorectal cancer surgery. n ‐3 FA did not benefit the subgroup of patients treated with adjuvant chemotherapy or decrease the risk of disease recurrence.
2474-9842
678-684
Sørensen, Lone Schmidt
8d4e4398-8ddc-44fb-b085-334cf8ce2f15
Rasmussen, Simon Ladefoged
24058dd1-f485-412c-af15-e42f6ea76359
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Yilmaz, Mette Nytoft
c96bb992-a423-469f-b90a-7aac8e9f45b0
Schmidt, Erik Berg
4bd542c7-5070-40b5-bc74-13601f5940d4
Thorlacius-Ussing, Ole
95f040d2-4ef3-4bc0-9379-bfa240390b57
Sørensen, Lone Schmidt
8d4e4398-8ddc-44fb-b085-334cf8ce2f15
Rasmussen, Simon Ladefoged
24058dd1-f485-412c-af15-e42f6ea76359
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Yilmaz, Mette Nytoft
c96bb992-a423-469f-b90a-7aac8e9f45b0
Schmidt, Erik Berg
4bd542c7-5070-40b5-bc74-13601f5940d4
Thorlacius-Ussing, Ole
95f040d2-4ef3-4bc0-9379-bfa240390b57

Sørensen, Lone Schmidt, Rasmussen, Simon Ladefoged, Calder, Philip, Yilmaz, Mette Nytoft, Schmidt, Erik Berg and Thorlacius-Ussing, Ole (2020) Long term outcomes after perioperative treatment with n-3 fatty acid supplements in colorectal cancer. BJS Open, 4 (4), 678-684. (doi:10.1002/bjs5.50295).

Record type: Article

Abstract

Background
This study aimed to evaluate the effect of perioperative supplementation with omega‐3 fatty acids (n ‐3 FA) on perioperative outcomes and survival in patients undergoing colorectal cancer surgery.

Methods
Patients scheduled for elective resection of colorectal cancer between 2007 and 2010 were randomized to either an n ‐3 FA‐enriched oral nutrition supplement (ONS) twice daily or a standard ONS (control) for 7 days before and after surgery. Outcome measures, including postoperative complications, 3‐year cumulative incidence of local or metastatic colorectal cancer recurrence and 5‐year overall survival, were compared between the groups.

Results
Of 148 patients enrolled in the study, 125 (65 patients receiving n ‐3 FA‐enriched ONS and 60 receiving standard ONS) were analysed. There were no differences in postoperative complications after surgery (P = 0·544). The risk of disease recurrence at 3 years was similar (relative risk 1·66, 95 per cent c.i. 0·65 to 4·26).The 5‐year survival rate of patients treated with n ‐3 FA was 69·2 (95 per cent c.i. 56·5 to 78·9) per cent, compared with 81·7 (69·3 to 89·4) per cent in the control group (P = 0·193). After adjustment for age, stage of disease and adjuvant chemotherapy, n ‐3 FA was associated with higher mortality compared with controls (hazard ratio 1·73, 95 per cent c.i. 1·06 to 2·83; P = 0·029). The interaction between n ‐3 FA and adjuvant chemotherapy was not statistically significant.

Conclusion
Perioperative supplementation with n ‐3 FA did not confer a survival benefit in patients undergoing colorectal cancer surgery. n ‐3 FA did not benefit the subgroup of patients treated with adjuvant chemotherapy or decrease the risk of disease recurrence.

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More information

Accepted/In Press date: 31 March 2020
e-pub ahead of print date: 11 May 2020
Published date: August 2020

Identifiers

Local EPrints ID: 439123
URI: http://eprints.soton.ac.uk/id/eprint/439123
ISSN: 2474-9842
PURE UUID: 1cfe8d5f-42af-4f6a-90b9-24a4e37ef3df
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 03 Apr 2020 16:31
Last modified: 26 Nov 2021 06:55

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Contributors

Author: Lone Schmidt Sørensen
Author: Simon Ladefoged Rasmussen
Author: Philip Calder ORCID iD
Author: Mette Nytoft Yilmaz
Author: Erik Berg Schmidt
Author: Ole Thorlacius-Ussing

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