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A protocol for a systematic review and meta-analysis to identify measures of breakthrough pain and evaluate their psychometric properties

A protocol for a systematic review and meta-analysis to identify measures of breakthrough pain and evaluate their psychometric properties
A protocol for a systematic review and meta-analysis to identify measures of breakthrough pain and evaluate their psychometric properties

INTRODUCTION: Breakthrough pain is common in children and adults with cancer and other conditions, including those approaching end-of-life, although it is often poorly managed, possibly partly due to a lack of validated assessment tools. This review aims to (1) identify all available instruments measuring breakthrough pain in infants, children, adolescents or adults and (2) critically appraise, compare and summarise the quality of the psychometric properties of the identified instruments using COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria.

METHODS AND ANALYSIS: Two searches will be carried out between October 2019 and January 2020, one for each aim of the review. The Cochrane Library, International Prospective Register of Systematic Reviews, Embase, Cumulative Index of Nursing and Allied Health Literature, Medical Literature Analysis and Retrieval System Online (MEDLINE), PsycINFO, Web of Science Core Collection, Google Scholar, the ProQuest Dissertations & Theses Database, Evidence Search and OpenGrey databases will be searched from database inception until the date the search is conducted. Reference lists of eligible articles will be screened and authors in the field contacted. For search 1, articles will be screened by two reviewers by abstract, and full-text where necessary, to identify if a breakthrough pain assessment was used. Search 2 will then be conducted to identify studies evaluating measurement properties of these assessments. Two reviewers will screen articles from search 2 by title and abstract. All potentially relevant studies will be screened by full text by both reviewers. For search 2, data will be extracted in parallel with the quality assessment process, as recommended by COSMIN. Two reviewers will assess methodological quality using the COSMIN Risk of Bias checklist and the COSMIN updated criteria for good measurement properties. Findings will be summarised and, if possible, data will be pooled using meta-analysis. The quality of the evidence will be graded and summarised using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines.

ETHICS AND DISSEMINATION: Results of this review will be submitted for publication in a peer review journal and presented at conferences.

PROSPERO REGISTRATION NUMBER: CRD42019155583.

cancer pain, neurological pain, pain management
2044-6055
e035541
Greenfield, Katie
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Holley, Simone
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Schoth, Daniel Eric
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Bayliss, Julie
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Anderson, Anna-Karenia
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Jassal, Satbir
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Rajapakse, Dilini
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Fraser, Lorna Katharine
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Mott, Christine
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Johnson, Margaret
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Wong, Ian
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Howard, Richard
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Harrop, Emily
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Liossi, Christina
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Greenfield, Katie
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Holley, Simone
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Schoth, Daniel Eric
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Bayliss, Julie
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Anderson, Anna-Karenia
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Jassal, Satbir
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Rajapakse, Dilini
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Fraser, Lorna Katharine
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Mott, Christine
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Johnson, Margaret
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Wong, Ian
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Howard, Richard
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Harrop, Emily
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Liossi, Christina
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Greenfield, Katie, Holley, Simone, Schoth, Daniel Eric, Bayliss, Julie, Anderson, Anna-Karenia, Jassal, Satbir, Rajapakse, Dilini, Fraser, Lorna Katharine, Mott, Christine, Johnson, Margaret, Wong, Ian, Howard, Richard, Harrop, Emily and Liossi, Christina (2020) A protocol for a systematic review and meta-analysis to identify measures of breakthrough pain and evaluate their psychometric properties. BMJ Open, 10 (3), e035541, [e035541]. (doi:10.1136/bmjopen-2019-035541).

Record type: Article

Abstract

INTRODUCTION: Breakthrough pain is common in children and adults with cancer and other conditions, including those approaching end-of-life, although it is often poorly managed, possibly partly due to a lack of validated assessment tools. This review aims to (1) identify all available instruments measuring breakthrough pain in infants, children, adolescents or adults and (2) critically appraise, compare and summarise the quality of the psychometric properties of the identified instruments using COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria.

METHODS AND ANALYSIS: Two searches will be carried out between October 2019 and January 2020, one for each aim of the review. The Cochrane Library, International Prospective Register of Systematic Reviews, Embase, Cumulative Index of Nursing and Allied Health Literature, Medical Literature Analysis and Retrieval System Online (MEDLINE), PsycINFO, Web of Science Core Collection, Google Scholar, the ProQuest Dissertations & Theses Database, Evidence Search and OpenGrey databases will be searched from database inception until the date the search is conducted. Reference lists of eligible articles will be screened and authors in the field contacted. For search 1, articles will be screened by two reviewers by abstract, and full-text where necessary, to identify if a breakthrough pain assessment was used. Search 2 will then be conducted to identify studies evaluating measurement properties of these assessments. Two reviewers will screen articles from search 2 by title and abstract. All potentially relevant studies will be screened by full text by both reviewers. For search 2, data will be extracted in parallel with the quality assessment process, as recommended by COSMIN. Two reviewers will assess methodological quality using the COSMIN Risk of Bias checklist and the COSMIN updated criteria for good measurement properties. Findings will be summarised and, if possible, data will be pooled using meta-analysis. The quality of the evidence will be graded and summarised using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines.

ETHICS AND DISSEMINATION: Results of this review will be submitted for publication in a peer review journal and presented at conferences.

PROSPERO REGISTRATION NUMBER: CRD42019155583.

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More information

Accepted/In Press date: 17 February 2020
e-pub ahead of print date: 29 March 2020
Keywords: cancer pain, neurological pain, pain management

Identifiers

Local EPrints ID: 439287
URI: http://eprints.soton.ac.uk/id/eprint/439287
ISSN: 2044-6055
PURE UUID: e5ccd531-fdba-43e5-b3bb-f27e5b4934f3
ORCID for Katie Greenfield: ORCID iD orcid.org/0000-0001-8827-6543
ORCID for Simone Holley: ORCID iD orcid.org/0000-0003-4631-2862
ORCID for Christina Liossi: ORCID iD orcid.org/0000-0003-0627-6377

Catalogue record

Date deposited: 07 Apr 2020 16:37
Last modified: 10 Jan 2022 03:17

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Contributors

Author: Simone Holley ORCID iD
Author: Daniel Eric Schoth
Author: Julie Bayliss
Author: Anna-Karenia Anderson
Author: Satbir Jassal
Author: Dilini Rajapakse
Author: Lorna Katharine Fraser
Author: Christine Mott
Author: Margaret Johnson
Author: Ian Wong
Author: Richard Howard
Author: Emily Harrop

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