Gut microbiome modulates the toxicity of hydrazine: a metabonomic study
Gut microbiome modulates the toxicity of hydrazine: a metabonomic study
The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.
Animals, Carcinogens/metabolism, Gastrointestinal Tract/metabolism, Hydrazines/metabolism, Magnetic Resonance Spectroscopy, Metabolomics/methods, Metagenome, Rats, Rats, Sprague-Dawley
351-355
Swann, Jonathan
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Wang, Yulan
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Abecia, Leticia
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Costabile, Adele
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Tuohy, Kieran
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Gibson, Glenn
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Roberts, David
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Sidaway, James
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Jones, Huw
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Wilson, Ian D
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Nicholson, Jeremy
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Holmes, Elaine
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April 2009
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Wang, Yulan
d352c9c6-30f0-457a-9a74-ee680e45da34
Abecia, Leticia
14c41ce3-3c61-42f7-b6ad-86d3c02b9489
Costabile, Adele
2f54d3f0-8414-4844-8296-e97f6097e09e
Tuohy, Kieran
c68343d9-e2d4-4609-b75b-40289a34bf70
Gibson, Glenn
24ac4753-4f78-475f-9766-5da179e2ab92
Roberts, David
07128a92-3bf3-4016-8379-47528cc3c740
Sidaway, James
923e9eeb-28a2-4fea-953e-fe43b7c4d652
Jones, Huw
9fcd816f-3f39-4ef5-af4f-3c94fe1e7537
Wilson, Ian D
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Nicholson, Jeremy
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Holmes, Elaine
d3b92a6b-1c3f-4758-b653-ba35afd3f57d
Swann, Jonathan, Wang, Yulan, Abecia, Leticia, Costabile, Adele, Tuohy, Kieran, Gibson, Glenn, Roberts, David, Sidaway, James, Jones, Huw, Wilson, Ian D, Nicholson, Jeremy and Holmes, Elaine
(2009)
Gut microbiome modulates the toxicity of hydrazine: a metabonomic study.
Molecular BioSystems, 5 (4), .
(doi:10.1039/b811468d).
Abstract
The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.
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More information
Accepted/In Press date: 8 December 2008
e-pub ahead of print date: 23 January 2009
Published date: April 2009
Keywords:
Animals, Carcinogens/metabolism, Gastrointestinal Tract/metabolism, Hydrazines/metabolism, Magnetic Resonance Spectroscopy, Metabolomics/methods, Metagenome, Rats, Rats, Sprague-Dawley
Identifiers
Local EPrints ID: 439338
URI: http://eprints.soton.ac.uk/id/eprint/439338
ISSN: 1742-2051
PURE UUID: d94b7593-41cb-4104-8864-eb229c1ff1f1
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Date deposited: 16 Apr 2020 16:39
Last modified: 17 Mar 2024 04:00
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Contributors
Author:
Yulan Wang
Author:
Leticia Abecia
Author:
Adele Costabile
Author:
Kieran Tuohy
Author:
Glenn Gibson
Author:
David Roberts
Author:
James Sidaway
Author:
Huw Jones
Author:
Ian D Wilson
Author:
Jeremy Nicholson
Author:
Elaine Holmes
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