Nutrimetabonomics: applications for nutritional sciences, with specific reference to gut microbial interactions
Nutrimetabonomics: applications for nutritional sciences, with specific reference to gut microbial interactions
Understanding the role of the diet in determining human health and disease is one major objective of modern nutrition. Mammalian biocomplexity necessitates the incorporation of systems biology technologies into contemporary nutritional research. Metabonomics is a powerful approach that simultaneously measures the low-molecular-weight compounds in a biological sample, enabling the metabolic status of a biological system to be characterized. Such biochemical profiles contain latent information relating to inherent parameters, such as the genotype, and environmental factors, including the diet and gut microbiota. Nutritional metabonomics, or nutrimetabonomics, is being increasingly applied to study molecular interactions between the diet and the global metabolic system. This review discusses three primary areas in which nutrimetabonomics has enjoyed successful application in nutritional research: the illumination of molecular relationships between nutrition and biochemical processes; elucidation of biomarker signatures of food components for use in dietary surveillance; and the study of complex trans-genomic interactions between the mammalian host and its resident gut microbiome. Finally, this review illustrates the potential for nutrimetabonomics in nutritional science as an indispensable tool to achieve personalized nutrition.
Animals, Biomarkers, Diet, Genotype, Health, Humans, Intestines/microbiology, Metabolomics/methods, Metagenome, Microbial Interactions, Nutritional Physiological Phenomena, Nutritional Sciences, Phenotype
381- 399
Claus, Sandrine P
aff1e04c-0946-4bdf-b761-4aa39c43ce9c
Swann, Jonathan R
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Claus, Sandrine P
aff1e04c-0946-4bdf-b761-4aa39c43ce9c
Swann, Jonathan R
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Claus, Sandrine P and Swann, Jonathan R
(2013)
Nutrimetabonomics: applications for nutritional sciences, with specific reference to gut microbial interactions.
Annual review of food science and technology, 4, .
(doi:10.1146/annurev-food-030212-182612).
Abstract
Understanding the role of the diet in determining human health and disease is one major objective of modern nutrition. Mammalian biocomplexity necessitates the incorporation of systems biology technologies into contemporary nutritional research. Metabonomics is a powerful approach that simultaneously measures the low-molecular-weight compounds in a biological sample, enabling the metabolic status of a biological system to be characterized. Such biochemical profiles contain latent information relating to inherent parameters, such as the genotype, and environmental factors, including the diet and gut microbiota. Nutritional metabonomics, or nutrimetabonomics, is being increasingly applied to study molecular interactions between the diet and the global metabolic system. This review discusses three primary areas in which nutrimetabonomics has enjoyed successful application in nutritional research: the illumination of molecular relationships between nutrition and biochemical processes; elucidation of biomarker signatures of food components for use in dietary surveillance; and the study of complex trans-genomic interactions between the mammalian host and its resident gut microbiome. Finally, this review illustrates the potential for nutrimetabonomics in nutritional science as an indispensable tool to achieve personalized nutrition.
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e-pub ahead of print date: 3 January 2013
Keywords:
Animals, Biomarkers, Diet, Genotype, Health, Humans, Intestines/microbiology, Metabolomics/methods, Metagenome, Microbial Interactions, Nutritional Physiological Phenomena, Nutritional Sciences, Phenotype
Identifiers
Local EPrints ID: 439401
URI: http://eprints.soton.ac.uk/id/eprint/439401
ISSN: 1941-1413
PURE UUID: eb7005c1-1816-44db-8413-0c544e4ecd1b
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Date deposited: 21 Apr 2020 16:52
Last modified: 17 Mar 2024 04:00
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Author:
Sandrine P Claus
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