Hippurate: the natural history of a mammalian-microbial cometabolite
Hippurate: the natural history of a mammalian-microbial cometabolite
Hippurate, the glycine conjugate of benzoic acid, is a normal constituent of the endogenous urinary metabolite profile and has long been associated with the microbial degradation of certain dietary components, hepatic function and toluene exposure, and is also commonly used as a measure of renal clearance. Here we discuss the potential relevance of hippurate excretion with regard to normal endogenous metabolism and trends in excretion relating to gender, age, and the intestinal microbiota. Additionally, the significance of hippurate excretion with respect to disease states including obesity, diabetes, gastrointestinal diseases, impaired renal function, psychological disorders and autism, as well as toxicity and parasitic infection, are considered.
Age Factors, Animals, Atherosclerosis/metabolism, Autistic Disorder/metabolism, Benzoic Acid/metabolism, Diabetes Mellitus/metabolism, Diet, Female, Gastrointestinal Diseases/metabolism, Gene-Environment Interaction, Glycine/metabolism, Hippurates/metabolism, Humans, Intestinal Mucosa/metabolism, Intestines/microbiology, Male, Mammals, Microbiota, Obesity/metabolism, Sex Factors, Species Specificity
1527 - 1546
Lees, Hannah J
065ec499-13b2-4a01-bd6a-7e2102905c84
Swann, Jonathan R
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Wilson, Ian D
d7da811b-6cc9-4166-82d0-e780c95122d2
Nicholson, Jeremy K
72991774-7e08-4592-ae57-e7dcc2ec158e
Holmes, Elaine
d3b92a6b-1c3f-4758-b653-ba35afd3f57d
5 April 2013
Lees, Hannah J
065ec499-13b2-4a01-bd6a-7e2102905c84
Swann, Jonathan R
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Wilson, Ian D
d7da811b-6cc9-4166-82d0-e780c95122d2
Nicholson, Jeremy K
72991774-7e08-4592-ae57-e7dcc2ec158e
Holmes, Elaine
d3b92a6b-1c3f-4758-b653-ba35afd3f57d
Lees, Hannah J, Swann, Jonathan R, Wilson, Ian D, Nicholson, Jeremy K and Holmes, Elaine
(2013)
Hippurate: the natural history of a mammalian-microbial cometabolite.
Journal of Proteome Research, 12 (4), .
(doi:10.1021/pr300900b).
Abstract
Hippurate, the glycine conjugate of benzoic acid, is a normal constituent of the endogenous urinary metabolite profile and has long been associated with the microbial degradation of certain dietary components, hepatic function and toluene exposure, and is also commonly used as a measure of renal clearance. Here we discuss the potential relevance of hippurate excretion with regard to normal endogenous metabolism and trends in excretion relating to gender, age, and the intestinal microbiota. Additionally, the significance of hippurate excretion with respect to disease states including obesity, diabetes, gastrointestinal diseases, impaired renal function, psychological disorders and autism, as well as toxicity and parasitic infection, are considered.
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e-pub ahead of print date: 23 January 2013
Published date: 5 April 2013
Keywords:
Age Factors, Animals, Atherosclerosis/metabolism, Autistic Disorder/metabolism, Benzoic Acid/metabolism, Diabetes Mellitus/metabolism, Diet, Female, Gastrointestinal Diseases/metabolism, Gene-Environment Interaction, Glycine/metabolism, Hippurates/metabolism, Humans, Intestinal Mucosa/metabolism, Intestines/microbiology, Male, Mammals, Microbiota, Obesity/metabolism, Sex Factors, Species Specificity
Identifiers
Local EPrints ID: 439403
URI: http://eprints.soton.ac.uk/id/eprint/439403
ISSN: 1535-3893
PURE UUID: 4ca2293a-6f85-47b0-b4ba-3cadd4330611
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Date deposited: 21 Apr 2020 16:52
Last modified: 17 Mar 2024 04:00
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Contributors
Author:
Hannah J Lees
Author:
Ian D Wilson
Author:
Jeremy K Nicholson
Author:
Elaine Holmes
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