Nutrimetabonomics: nutritional applications of metabolic profiling
Nutrimetabonomics: nutritional applications of metabolic profiling
An individual's metabolic phenotype, and ultimately health, is significantly influenced by complex interactions between their genes and the diet. Studying these associations and their downstream biochemical consequences has proven extremely challenging using traditional hypothesis-led strategies. Metabonomics, a systems biology approach, allows the global metabolic response of biological systems to stimuli to be characterised. Through the application of this approach to nutritional-based research, nutrimetabonomics, the biochemical response to dietary inputs is being investigated at greater levels of resolution. This has allowed novel insights to be gained regarding intricate diet-gene interactions and their consequences for health and disease. In this review, we present some of the latest research exploring how nutrimetabonomics can assist in the elucidation of novel biomarkers of dietary behaviour and provide new perspectives on diet-health relationships. The use of this approach to study the metabolic interplay between the gut microbiota and the host is also explored.
Diet, Gene-Environment Interaction, Genotype, Humans, Metabolome/genetics, Metabolomics, Microbiota/physiology, Nutritional Status/genetics, Phenotype
41-47
Swann, Jonathan R
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Claus, Sandrine P
aff1e04c-0946-4bdf-b761-4aa39c43ce9c
1 March 2014
Swann, Jonathan R
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Claus, Sandrine P
aff1e04c-0946-4bdf-b761-4aa39c43ce9c
Swann, Jonathan R and Claus, Sandrine P
(2014)
Nutrimetabonomics: nutritional applications of metabolic profiling.
Science Progress, 97 (1), .
(doi:10.3184/003685014X13898807933527).
Abstract
An individual's metabolic phenotype, and ultimately health, is significantly influenced by complex interactions between their genes and the diet. Studying these associations and their downstream biochemical consequences has proven extremely challenging using traditional hypothesis-led strategies. Metabonomics, a systems biology approach, allows the global metabolic response of biological systems to stimuli to be characterised. Through the application of this approach to nutritional-based research, nutrimetabonomics, the biochemical response to dietary inputs is being investigated at greater levels of resolution. This has allowed novel insights to be gained regarding intricate diet-gene interactions and their consequences for health and disease. In this review, we present some of the latest research exploring how nutrimetabonomics can assist in the elucidation of novel biomarkers of dietary behaviour and provide new perspectives on diet-health relationships. The use of this approach to study the metabolic interplay between the gut microbiota and the host is also explored.
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Published date: 1 March 2014
Keywords:
Diet, Gene-Environment Interaction, Genotype, Humans, Metabolome/genetics, Metabolomics, Microbiota/physiology, Nutritional Status/genetics, Phenotype
Identifiers
Local EPrints ID: 439406
URI: http://eprints.soton.ac.uk/id/eprint/439406
ISSN: 0036-8504
PURE UUID: f0dddae6-50fc-40be-b329-60555a0636cf
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Date deposited: 21 Apr 2020 16:52
Last modified: 17 Mar 2024 04:00
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Author:
Sandrine P Claus
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