Frequency of food allergy in school-aged children in eight European countries - the EuroPrevall-iFAAM birth cohort
Frequency of food allergy in school-aged children in eight European countries - the EuroPrevall-iFAAM birth cohort
Background: The prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent-reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries. Methods: A follow-up assessment at age 6-10 years of a multicentre European birth cohort based was undertaken using an online parental questionnaire, clinical visits including structured interviews and skin prick tests (SPT). Children with suspected FA were scheduled for double-blind, placebo-controlled oral food challenges (DBPCFC). Results: A total of 6105 children participated in this school-age follow-up (57.8% of 10 563 recruited at birth). For 982 of 6069 children (16.2%), parents reported adverse reactions after food consumption in the online questionnaire. Of 2288 children with parental face-to-face interviews and/or skin prick testing, 238 (10.4%) were eligible for a DBPCFC. Sixty-three foods were challenge-tested in 46 children. Twenty food challenges were positive in 17 children, including seven to hazelnut and three to peanut. Another seventy-one children were estimated to suffer FA among those who were eligible but refused DBPCFC. This yielded prevalence estimates for FA in school age between 1.4% (88 related to all 6105 participants of this follow-up) and 3.8% (88 related to 2289 with completed eligibility assessment). Interpretation: In primary school children in eight European countries, the prevalence of FA was lower than expected even though parents of this cohort have become especially aware of allergic reactions to food. There was moderate variation between centres hampering valid regional comparisons.
IgE, birth cohort study, epidemiology, food allergy, prevalence
2294-2308
Grabenhenrich, L.
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Trendelenburg, V.
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Bellach, J.
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Yürek, S.
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Reich, A.
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Fiandor, A.
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Rivero, D.
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Sigurdardottir, S.T.
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Clausen, M.
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Papadopoulos, N.G.
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Xepapadaki, P.
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Sprikkelman, A.B.
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Dontje, B.
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Roberts, G.
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Grimshaw, K.
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Kowalski, M.L.
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Kurowski, M.
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Dubakiene, R.
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Rudzeviciene, O.
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Fernández-Rivas, M.
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Couch, P.
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Versteeg, S.A.
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van Ree, R.
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Mills, E.N.C.
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Keil, T.
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Beyer, K.
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1 September 2020
Grabenhenrich, L.
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Trendelenburg, V.
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Bellach, J.
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Yürek, S.
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Reich, A.
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Fiandor, A.
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Rivero, D.
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Sigurdardottir, S.T.
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Clausen, M.
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Papadopoulos, N.G.
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Xepapadaki, P.
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Sprikkelman, A.B.
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Dontje, B.
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Roberts, G.
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Grimshaw, K.
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Kowalski, M.L.
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Kurowski, M.
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Dubakiene, R.
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Rudzeviciene, O.
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Fernández-Rivas, M.
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Couch, P.
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Versteeg, S.A.
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van Ree, R.
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Mills, E.N.C.
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Keil, T.
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Beyer, K.
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Grabenhenrich, L., Trendelenburg, V., Bellach, J., Yürek, S., Reich, A., Fiandor, A., Rivero, D., Sigurdardottir, S.T., Clausen, M., Papadopoulos, N.G., Xepapadaki, P., Sprikkelman, A.B., Dontje, B., Roberts, G., Grimshaw, K., Kowalski, M.L., Kurowski, M., Dubakiene, R., Rudzeviciene, O., Fernández-Rivas, M., Couch, P., Versteeg, S.A., van Ree, R., Mills, E.N.C., Keil, T. and Beyer, K.
(2020)
Frequency of food allergy in school-aged children in eight European countries - the EuroPrevall-iFAAM birth cohort.
Allergy, 75 (9), .
(doi:10.1111/all.14290).
Abstract
Background: The prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent-reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries. Methods: A follow-up assessment at age 6-10 years of a multicentre European birth cohort based was undertaken using an online parental questionnaire, clinical visits including structured interviews and skin prick tests (SPT). Children with suspected FA were scheduled for double-blind, placebo-controlled oral food challenges (DBPCFC). Results: A total of 6105 children participated in this school-age follow-up (57.8% of 10 563 recruited at birth). For 982 of 6069 children (16.2%), parents reported adverse reactions after food consumption in the online questionnaire. Of 2288 children with parental face-to-face interviews and/or skin prick testing, 238 (10.4%) were eligible for a DBPCFC. Sixty-three foods were challenge-tested in 46 children. Twenty food challenges were positive in 17 children, including seven to hazelnut and three to peanut. Another seventy-one children were estimated to suffer FA among those who were eligible but refused DBPCFC. This yielded prevalence estimates for FA in school age between 1.4% (88 related to all 6105 participants of this follow-up) and 3.8% (88 related to 2289 with completed eligibility assessment). Interpretation: In primary school children in eight European countries, the prevalence of FA was lower than expected even though parents of this cohort have become especially aware of allergic reactions to food. There was moderate variation between centres hampering valid regional comparisons.
Text
all.14290
- Accepted Manuscript
More information
e-pub ahead of print date: 27 March 2020
Published date: 1 September 2020
Additional Information:
Funding Information:
All authors report EU grant support as described under Role of the funding source; M Fernandez‐Rivas reports grants from the Spanish government (MINECO, ISCIII), grants and personal fees from Aimmune Therapeutics, personal fees from Allergy Therapeutics, Fundación SEAIC, HAL, Thermo Fisher Scientific, Schreiber Foods, DBV, outside the submitted work; and patent PCT/ES2014/070634 issued; NG Papadopoulos reports grants from Gerolymatos, personal fees from Hal Allergy BV, Novartis Pharma AG, Menarini, Hal Allergy BV, Mylan, outside the submitted work; D Rivero reports employment as a MSL (medical science liaison) for genetic diseases at Shire pharmaceuticals; ST Sigurdardottir reports personal fees from Icepharma pharmaceutical company, outside the submitted work; V Xepapadaki reports personal fees from Uriach, Novartis, Nestlé, Nutricia, outside the submitted work; R van Ree reports personal fees from HAL Allergy BV, Citeq BV, ThermoFisher Scientific, outside the submitted work; ENC Mills reports grants from Reacta Biotech Ltd, outside the submitted work; and Chief Scientific Adviser and shareholder of Reacta Biotech Ltd, a start‐up developed to commercialise foods for use in oral food challenges; K Beyer reports grants from European Commission, during the conduct of the study; grants and personal fees from Aimmune, Danone, Infectopharm, personal fees from Bencard, Hycor, Mabylon AG, Mylan, Nestle and grants from ALK, DBV, Hipp, outside the submitted work. All other authors have nothing to disclose.
Publisher Copyright:
© 2020 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd
Keywords:
IgE, birth cohort study, epidemiology, food allergy, prevalence
Identifiers
Local EPrints ID: 439514
URI: http://eprints.soton.ac.uk/id/eprint/439514
ISSN: 0105-4538
PURE UUID: d6cf608e-e5a3-4b62-9047-8a992bad23b0
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Date deposited: 24 Apr 2020 16:44
Last modified: 17 Mar 2024 05:28
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Contributors
Author:
L. Grabenhenrich
Author:
V. Trendelenburg
Author:
J. Bellach
Author:
S. Yürek
Author:
A. Reich
Author:
A. Fiandor
Author:
D. Rivero
Author:
S.T. Sigurdardottir
Author:
M. Clausen
Author:
N.G. Papadopoulos
Author:
P. Xepapadaki
Author:
A.B. Sprikkelman
Author:
B. Dontje
Author:
M.L. Kowalski
Author:
M. Kurowski
Author:
R. Dubakiene
Author:
O. Rudzeviciene
Author:
M. Fernández-Rivas
Author:
P. Couch
Author:
S.A. Versteeg
Author:
R. van Ree
Author:
E.N.C. Mills
Author:
T. Keil
Author:
K. Beyer
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