The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Frequency of food allergy in school-aged children in eight European countries - the EuroPrevall-iFAAM birth cohort

Frequency of food allergy in school-aged children in eight European countries - the EuroPrevall-iFAAM birth cohort
Frequency of food allergy in school-aged children in eight European countries - the EuroPrevall-iFAAM birth cohort

BACKGROUND: The prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent-reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries.

METHODS: A follow-up assessment at age 6-10 years of a multi-centre European birth cohort, based was undertaken using an online parental questionnaire, clinical visits including structured interviews and skin prick tests (SPT). Children with suspected FA were scheduled for double-blind, placebo-controlled oral food challenges (DBPCFC).

RESULTS: 6,105 children participated in in this school-age follow-up (57.8% of 10,563 recruited at birth). For 982 of 6,069 children (16.2%), parents reported adverse reactions after food consumption in the online questionnaire. Of 2,288 children with parental face-to-face interviews and/or skin prick testing, 238 (10.4%) were eligible for a DBPCFC. 63 foods were challenge-tested in 46 children. 20 food challenges were positive in 17 children, including seven to hazelnut and three to peanut. Another seventy-one children were estimated to suffer FA among those who were eligible but refused DBPCFC. This yielded prevalence estimates for FA in school-age between 1.4% (88 related to all 6,105 participants of this follow-up) and 3.8% (88 related to 2,289 with completed eligibility assessment).

INTERPRETATION: In primary school children in eight European countries, the prevalence of FA was lower than expected even though parents of this cohort have become especially aware of allergic reactions to food. There was moderate variation between centres hampering valid regional comparisons.

IgE, birth cohort study, epidemiology, food allergy, prevalence
0105-4538
2294-2308
Grabenhenrich, L.
c0078333-0505-4c5c-9cec-9cccca6207d3
Trendelenburg, V.
79adcd41-1a74-426b-8cb6-3424aaa26692
Bellach, J.
fe740e95-5a47-4106-aaba-374b36a5f44e
Yürek, S.
56a3d9dc-859e-4fee-adda-7683a0e8a4ad
Reich, A.
6006e24f-5f8c-41ab-933a-d558e6cdf40d
Fiandor, A.
59859001-873b-4501-8f16-78b5abfce12b
Rivero, D.
c3c34def-eec7-46ef-aad5-7b307cfcf164
Sigurdardottir, S.T.
768a2385-c0c4-4281-84b3-1346fcd7217b
Clausen, M.
cc2c5328-d0a9-4a65-a51a-cb22c1a5e371
Papadopoulos, N.G.
245190e1-f850-414c-973a-780c4ffae728
Xepapadaki, P.
70aee30c-cf02-40a8-9773-5e13bc3dad43
Sprikkelman, A.B.
1b6666fe-2c17-4acc-bfad-a435f0490d17
Dontje, B.
6c64fcb1-b476-4125-b6d1-4afc7adcf822
Roberts, G.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Grimshaw, K.
766b6cf0-347a-447d-aeab-f07366f8ce28
Kowalski, M.L.
e7f74c51-e1e6-453e-962d-f4fe537d0707
Kurowski, M.
2df3a6f1-2dae-4133-9dce-e2379ae5ef0c
Dubakiene, R.
363ddaa7-d0ad-4942-8855-e7f5393836dd
Rudzeviciene, O.
6b2443ed-2e99-475f-9a6d-e119163c08aa
Fernández-Rivas, M.
3469c734-f588-4c75-b2ad-f1a3bdb8fbb6
Couch, P.
2ee9e78d-3373-4ef9-811e-2ef414323665
Versteeg, S.A.
82d31da0-2997-4d79-85d0-719ba0fc0357
van Ree, R.
4100f8ce-ece6-4ab0-9a4f-e0e862ef078d
Mills, E.N.C.
bd1b7b6f-187e-4a17-93ee-1cfc518a708f
Keil, T.
7b3edd35-b6fe-463c-a33c-8d8efa687686
Beyer, K.
edb4db7d-a39e-4a3a-a5b1-827b79db148b
Grabenhenrich, L.
c0078333-0505-4c5c-9cec-9cccca6207d3
Trendelenburg, V.
79adcd41-1a74-426b-8cb6-3424aaa26692
Bellach, J.
fe740e95-5a47-4106-aaba-374b36a5f44e
Yürek, S.
56a3d9dc-859e-4fee-adda-7683a0e8a4ad
Reich, A.
6006e24f-5f8c-41ab-933a-d558e6cdf40d
Fiandor, A.
59859001-873b-4501-8f16-78b5abfce12b
Rivero, D.
c3c34def-eec7-46ef-aad5-7b307cfcf164
Sigurdardottir, S.T.
768a2385-c0c4-4281-84b3-1346fcd7217b
Clausen, M.
cc2c5328-d0a9-4a65-a51a-cb22c1a5e371
Papadopoulos, N.G.
245190e1-f850-414c-973a-780c4ffae728
Xepapadaki, P.
70aee30c-cf02-40a8-9773-5e13bc3dad43
Sprikkelman, A.B.
1b6666fe-2c17-4acc-bfad-a435f0490d17
Dontje, B.
6c64fcb1-b476-4125-b6d1-4afc7adcf822
Roberts, G.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Grimshaw, K.
766b6cf0-347a-447d-aeab-f07366f8ce28
Kowalski, M.L.
e7f74c51-e1e6-453e-962d-f4fe537d0707
Kurowski, M.
2df3a6f1-2dae-4133-9dce-e2379ae5ef0c
Dubakiene, R.
363ddaa7-d0ad-4942-8855-e7f5393836dd
Rudzeviciene, O.
6b2443ed-2e99-475f-9a6d-e119163c08aa
Fernández-Rivas, M.
3469c734-f588-4c75-b2ad-f1a3bdb8fbb6
Couch, P.
2ee9e78d-3373-4ef9-811e-2ef414323665
Versteeg, S.A.
82d31da0-2997-4d79-85d0-719ba0fc0357
van Ree, R.
4100f8ce-ece6-4ab0-9a4f-e0e862ef078d
Mills, E.N.C.
bd1b7b6f-187e-4a17-93ee-1cfc518a708f
Keil, T.
7b3edd35-b6fe-463c-a33c-8d8efa687686
Beyer, K.
edb4db7d-a39e-4a3a-a5b1-827b79db148b

Grabenhenrich, L., Trendelenburg, V., Bellach, J., Yürek, S., Reich, A., Fiandor, A., Rivero, D., Sigurdardottir, S.T., Clausen, M., Papadopoulos, N.G., Xepapadaki, P., Sprikkelman, A.B., Dontje, B., Roberts, G., Grimshaw, K., Kowalski, M.L., Kurowski, M., Dubakiene, R., Rudzeviciene, O., Fernández-Rivas, M., Couch, P., Versteeg, S.A., van Ree, R., Mills, E.N.C., Keil, T. and Beyer, K. (2020) Frequency of food allergy in school-aged children in eight European countries - the EuroPrevall-iFAAM birth cohort. Allergy, 75 (9), 2294-2308. (doi:10.1111/all.14290).

Record type: Article

Abstract

BACKGROUND: The prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent-reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries.

METHODS: A follow-up assessment at age 6-10 years of a multi-centre European birth cohort, based was undertaken using an online parental questionnaire, clinical visits including structured interviews and skin prick tests (SPT). Children with suspected FA were scheduled for double-blind, placebo-controlled oral food challenges (DBPCFC).

RESULTS: 6,105 children participated in in this school-age follow-up (57.8% of 10,563 recruited at birth). For 982 of 6,069 children (16.2%), parents reported adverse reactions after food consumption in the online questionnaire. Of 2,288 children with parental face-to-face interviews and/or skin prick testing, 238 (10.4%) were eligible for a DBPCFC. 63 foods were challenge-tested in 46 children. 20 food challenges were positive in 17 children, including seven to hazelnut and three to peanut. Another seventy-one children were estimated to suffer FA among those who were eligible but refused DBPCFC. This yielded prevalence estimates for FA in school-age between 1.4% (88 related to all 6,105 participants of this follow-up) and 3.8% (88 related to 2,289 with completed eligibility assessment).

INTERPRETATION: In primary school children in eight European countries, the prevalence of FA was lower than expected even though parents of this cohort have become especially aware of allergic reactions to food. There was moderate variation between centres hampering valid regional comparisons.

Text
all.14290 - Accepted Manuscript
Download (13MB)

More information

e-pub ahead of print date: 27 March 2020
Keywords: IgE, birth cohort study, epidemiology, food allergy, prevalence

Identifiers

Local EPrints ID: 439514
URI: http://eprints.soton.ac.uk/id/eprint/439514
ISSN: 0105-4538
PURE UUID: d6cf608e-e5a3-4b62-9047-8a992bad23b0
ORCID for G. Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 24 Apr 2020 16:44
Last modified: 26 Nov 2021 07:16

Export record

Altmetrics

Contributors

Author: L. Grabenhenrich
Author: V. Trendelenburg
Author: J. Bellach
Author: S. Yürek
Author: A. Reich
Author: A. Fiandor
Author: D. Rivero
Author: S.T. Sigurdardottir
Author: M. Clausen
Author: N.G. Papadopoulos
Author: P. Xepapadaki
Author: A.B. Sprikkelman
Author: B. Dontje
Author: G. Roberts ORCID iD
Author: K. Grimshaw
Author: M.L. Kowalski
Author: M. Kurowski
Author: R. Dubakiene
Author: O. Rudzeviciene
Author: M. Fernández-Rivas
Author: P. Couch
Author: S.A. Versteeg
Author: R. van Ree
Author: E.N.C. Mills
Author: T. Keil
Author: K. Beyer

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×