Targeting heat shock proteins in colorectal cancer

Lee, Sheah, Dempsey-Hibbert, Nina, Vimalachandran, Dale, David Wardle, Terence, Sutton, Paul and Williams, John H.H. (2015) Targeting heat shock proteins in colorectal cancer. In, Asea, A., Almasoud, N., Krishnan, S. and Kaur, P. (eds.) Heat Shock Protein-Based Therapies. (Heat Shock Proteins, 9) Cham. Springer, pp. 345-379. (doi:10.1007/978-3-319-17211-8_17).

Abstract

Colorectal cancer (CRC) causes over half a million deaths worldwide and has a particularly poor prognosis when diagnosed at an advanced stage. Heat shock proteins (HSP) have been found to be elevated in CRC patients and HSPB1, HSPA1A and HSPC1 has been shown to have some prognostic value. CRC, in common with all cancers, has important associated oncogene and tumor suppressor gene associations and we show how many of these interact directly with one or more of the HSP. We discuss the current chemotherapeutic options available to the clinician when presented with CRC and how these may be improved with a consideration of the role of HSP in the development of the tumor as well as the response to therapy. Direct manipulation of HSP has the potential to decrease the therapeutic dose of anti-tumor drugs and we propose novel strategies that have the potential to be adapted to the clinic.

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