Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections
Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections
Public health practices including handwashing and vaccinations help reduce the spread and impact of infections. Nevertheless, the global burden of infection is high, and additional measures are necessary. Acute respiratory tract infections, for example, were responsible for more than 2.38 million deaths worldwide in 2016. The role nutrition plays in supporting the immune system is well‐established. A wealth of mechanistic and clinical data show that vitamins, including vitamins A, B6, B12, C, D, E, and folate; trace elements, including zinc, iron, selenium, magnesium, and copper; and the omega‐3 fatty acids eicosapentaenoic acid and docosahexaenoic acid play important and complementary roles in supporting the immune system. Inadequate intake and status of these nutrients are widespread, leading to a decrease in resistance to infections and as a consequence an increase in disease burden. Against this background the following conclusions are made: 1) Supplementation with the above micronutrients and omega‐3 fatty acids is a safe, effective, and low‐cost strategy to help support optimal immune function; 2) Supplementation above the RDA, but within recommended upper safety limits, for specific nutrients such as vitamins C and D is warranted; and 3) Public health officials are encouraged to include nutritional strategies in their recommendations to improve public health.
COVID-19, Immune system, Influenza, Micronutrients, Minerals, Omega-3 fatty acids, Viral infection, Vitamin C, Vitamin D, Vitamins
1-10
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Carr, Anitra C.
2071fad6-8097-49ac-a702-80f327d29aa2
Gombart, Adrian F.
e9fe8071-c8d0-456b-9524-7ab2bcb34a44
Eggersdorfer, Manfred
48d01cdd-f8ac-4d0c-ad34-0d22b1bf187c
April 2020
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Carr, Anitra C.
2071fad6-8097-49ac-a702-80f327d29aa2
Gombart, Adrian F.
e9fe8071-c8d0-456b-9524-7ab2bcb34a44
Eggersdorfer, Manfred
48d01cdd-f8ac-4d0c-ad34-0d22b1bf187c
Calder, Philip, Carr, Anitra C., Gombart, Adrian F. and Eggersdorfer, Manfred
(2020)
Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections.
Nutrients, 12 (4), , [1181].
(doi:10.3390/nu12041181).
Abstract
Public health practices including handwashing and vaccinations help reduce the spread and impact of infections. Nevertheless, the global burden of infection is high, and additional measures are necessary. Acute respiratory tract infections, for example, were responsible for more than 2.38 million deaths worldwide in 2016. The role nutrition plays in supporting the immune system is well‐established. A wealth of mechanistic and clinical data show that vitamins, including vitamins A, B6, B12, C, D, E, and folate; trace elements, including zinc, iron, selenium, magnesium, and copper; and the omega‐3 fatty acids eicosapentaenoic acid and docosahexaenoic acid play important and complementary roles in supporting the immune system. Inadequate intake and status of these nutrients are widespread, leading to a decrease in resistance to infections and as a consequence an increase in disease burden. Against this background the following conclusions are made: 1) Supplementation with the above micronutrients and omega‐3 fatty acids is a safe, effective, and low‐cost strategy to help support optimal immune function; 2) Supplementation above the RDA, but within recommended upper safety limits, for specific nutrients such as vitamins C and D is warranted; and 3) Public health officials are encouraged to include nutritional strategies in their recommendations to improve public health.
Text
Calder et al nutrients 756117 ME
- Accepted Manuscript
Text
nutrients-12-01181
- Version of Record
More information
Accepted/In Press date: 18 April 2020
e-pub ahead of print date: 23 April 2020
Published date: April 2020
Keywords:
COVID-19, Immune system, Influenza, Micronutrients, Minerals, Omega-3 fatty acids, Viral infection, Vitamin C, Vitamin D, Vitamins
Identifiers
Local EPrints ID: 439543
URI: http://eprints.soton.ac.uk/id/eprint/439543
ISSN: 2072-6643
PURE UUID: 480072a3-0631-4b69-aa28-974a3de9016c
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Date deposited: 27 Apr 2020 16:30
Last modified: 28 Apr 2022 01:40
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Contributors
Author:
Anitra C. Carr
Author:
Adrian F. Gombart
Author:
Manfred Eggersdorfer
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