Primary colorectal cells culture as a translational research model
Primary colorectal cells culture as a translational research model
Preclinical studies are an essential stage for any pharmacological agent hoping to make its way into clinical trials. An ideal preclinical model that can accurately predict clinical response does not exist and the best that the scientific community have at the moment is to select the most relevant study model pertaining to the disease of interest from those available, which includes: cell lines, animal models, and even in-silico methodology. Currently, there is a huge gap between preclinical and clinical trial results, indicating that there is much room for improvement in developing a better model to bridge the translational gap.
Animals, Colorectal Neoplasms, Disease Models, Animal, Humans, Primary Cell Culture/methods, Translational Medical Research/methods
97-105
Lee, Sheah Lin
73132638-fb25-413d-9a81-6040c37eb2c3
Dempsey-Hibbert, Nina Claire
32b6618d-7d68-4817-b4e7-a30dfcc6c5cd
Vimalachandran, Dale
ba43e3b0-9f08-4361-8328-69dcaaaf7a2f
Wardle, Terence David
43359d9f-f273-4afe-ace9-2003c1816507
Sutton, Paul A.
b9a9d1cf-1a82-4054-a47f-6be9674b9c75
Williams, John H.H.
48403723-71bc-4e39-8d97-929a018afe22
2018
Lee, Sheah Lin
73132638-fb25-413d-9a81-6040c37eb2c3
Dempsey-Hibbert, Nina Claire
32b6618d-7d68-4817-b4e7-a30dfcc6c5cd
Vimalachandran, Dale
ba43e3b0-9f08-4361-8328-69dcaaaf7a2f
Wardle, Terence David
43359d9f-f273-4afe-ace9-2003c1816507
Sutton, Paul A.
b9a9d1cf-1a82-4054-a47f-6be9674b9c75
Williams, John H.H.
48403723-71bc-4e39-8d97-929a018afe22
Lee, Sheah Lin, Dempsey-Hibbert, Nina Claire, Vimalachandran, Dale, Wardle, Terence David, Sutton, Paul A. and Williams, John H.H.
(2018)
Primary colorectal cells culture as a translational research model.
In,
Calderwood, S. and Prince, T.
(eds.)
Chaperones.
(Methods in Molecular Biology, 1709)
New York, NY.
Humana Press, .
(doi:10.1007/978-1-4939-7477-1_8).
Record type:
Book Section
Abstract
Preclinical studies are an essential stage for any pharmacological agent hoping to make its way into clinical trials. An ideal preclinical model that can accurately predict clinical response does not exist and the best that the scientific community have at the moment is to select the most relevant study model pertaining to the disease of interest from those available, which includes: cell lines, animal models, and even in-silico methodology. Currently, there is a huge gap between preclinical and clinical trial results, indicating that there is much room for improvement in developing a better model to bridge the translational gap.
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e-pub ahead of print date: 26 November 2017
Published date: 2018
Keywords:
Animals, Colorectal Neoplasms, Disease Models, Animal, Humans, Primary Cell Culture/methods, Translational Medical Research/methods
Identifiers
Local EPrints ID: 439560
URI: http://eprints.soton.ac.uk/id/eprint/439560
ISSN: 1064-3745
PURE UUID: 03cc5cf5-8793-45f3-af0c-f904fed6f150
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Date deposited: 27 Apr 2020 16:30
Last modified: 16 Mar 2024 07:40
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Contributors
Author:
Nina Claire Dempsey-Hibbert
Author:
Dale Vimalachandran
Author:
Terence David Wardle
Author:
Paul A. Sutton
Author:
John H.H. Williams
Editor:
S. Calderwood
Editor:
T. Prince
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