Phenotypic and functional translation of IL33 genetics in asthma

Accepted/In Press date: 14 April 2020

e-pub ahead of print date: 19 May 2020

Published date: 19 January 2021

Additional Information: Funding Information: This study was supported by Lung Foundation Netherlands grants AF 95.05 (G.H.K.), AF 98.48 (G.H.K.), and AF3.2.09.081JU (G.H.K., M.C.N.), the University Medical Center Groningen (G.H.K.), Dutch TerMeulen Fund (M.E.K.), the Ubbo Emmius Foundation (G.H.K.), and a grant from GlaxoSmithKline (I.S., I.H., M.C.N., G.H.K.). The Lifelines Biobank initiative has been made possible by subsidy from the Dutch Ministry of Health, Welfare and Sport; the Dutch Ministry of Economic Affairs; the University Medical Center Groningen; University Groningen; and the Northern Provinces of the Netherlands. The generation of the lung tissue dataset was funded by Merck. This study was also funded by an Asthma UK grant AUK-PG-2013-188 (I.S., I.P.H., D.E.S., C.E.B.) and additional funding by Asthma UK grants 10/006 and 11/031 (I.S., D.E.S.). Genotyping in GASP (Genetics of Asthma Severity & Phenotypes) cohort was additionally supported by Rosetrees Trust (I.S.) and AirPROM (C.E.B., M.T., I.S.). This work was supported by the Medical Research Council grant MC_PC_12010, a Strategic Award (I.P.H., M.D.T., L.V.W.), and Medical Research Council project grant G1100163 (S.R.J.). L.V.W. holds the GSK/British Lung Foundation Chair in Respiratory Research. Asthma UK funded the GASP Initiative (grant AUK-PG-2013-188). This work was part funded by the National Institute for Health Research Leicester Respiratory Biomedical Centre. A.S. is supported by the Manchester Biomedical Research Centre. Disclosure of potential conflict of interest: G.H. Koppelman, M.C. Nawijn, M.E. Ketelaar, C.J. Xu, M.A. Portelli, I. Sayers, and I.P. Hall report research funding from GlaxoSmithKline relating to this manuscript. I. Sayers has had research funding relating to this manuscript from AnaptysBio Inc. J.D. Blakely reports personal fees and nonfinancial support from Napp, personal fees from Novartis, personal fees and nonfinancial support from Astra Zeneca, personal fees and nonfinancial support from Boehringer Ingelheim, personal fees from Teva, and personal fees from Innovate UK, outside the submitted work. S.R. Johnson reports grants from Medical Research Council, during the conduct of the study, and nonfinancial support from Boehringer-Ingelheim, outside the submitted work. C.E. Brightling reports grants from AirPROM FP7, grants from Asthma UK, and grants from National Institute for Health Research Biomedical Research Centre, during the conduct of the study. D.E. Shaw reports grants from GlaxoSmithKline, during the conduct of the study, and grants from GlaxoSmithKline, outside the submitted work. G.H. Koppelman reports grants from TEVA the Netherlands, Vertex, and Stichting Astma Bestrijding, outside the submitted work, and advisory board fees from GlaxoSmithKline and PureIMS, outside the submitted work. M.C. Nawijn reports grants from GlaxoSmithKline, outside the submitted work. I. Sayers reports grants from GlaxoSmithKline and grants from Anaptsbio Inc, outside the submitted work. R. Chaudhuri reports personal fees and nonfinancial support from AstraZeneca, personal fees from GlaxoSmithKline, personal fees from Teva Pharmaceuticals, and personal fees and nonfinancial support from Novartis, outside the submitted work. A.V. Benest and D.O. Bates are supported by British Heart Foundation grant. A.V. Benest is supported by a Royal Society Project grant RGS?R1?191221. The remaining authors have declared that no conflict of interest exists. Funding Information: This study was supported by Lung Foundation Netherlands grants AF 95.05 (G.H.K.), AF 98.48 (G.H.K.), and AF3.2.09.081JU (G.H.K., M.C.N.), the University Medical Center Groningen (G.H.K.), Dutch TerMeulen Fund (M.E.K.), the Ubbo Emmius Foundation (G.H.K.), and a grant from GlaxoSmithKline (I.S., I.H., M.C.N., G.H.K.). The Lifelines Biobank initiative has been made possible by subsidy from the Dutch Ministry of Health, Welfare and Sport; the Dutch Ministry of Economic Affairs; the University Medical Center Groningen; University Groningen; and the Northern Provinces of the Netherlands. The generation of the lung tissue dataset was funded by Merck . This study was also funded by an Asthma UK grant AUK-PG-2013-188 (I.S., I.P.H., D.E.S., C.E.B.) and additional funding by Asthma UK grants 10/006 and 11/031 (I.S., D.E.S.). Genotyping in GASP (Genetics of Asthma Severity & Phenotypes) cohort was additionally supported by Rosetrees Trust (I.S.) and AirPROM (C.E.B., M.T., I.S.). This work was supported by the Medical Research Council grant MC_PC_12010 , a Strategic Award (I.P.H., M.D.T., L.V.W.), and Medical Research Council project grant G1100163 (S.R.J.). L.V.W. holds the GSK/British Lung Foundation Chair in Respiratory Research. Asthma UK funded the GASP Initiative (grant AUK-PG-2013-188 ). This work was part funded by the National Institute for Health Research Leicester Respiratory Biomedical Centre. A.S. is supported by the Manchester Biomedical Research Centre . Funding Information: Disclosure of potential conflict of interest: G.H. Koppelman, M.C. Nawijn, M.E. Ketelaar, C.J. Xu, M.A. Portelli, I. Sayers, and I.P. Hall report research funding from GlaxoSmithKline relating to this manuscript. I. Sayers has had research funding relating to this manuscript from AnaptysBio Inc. J.D. Blakely reports personal fees and nonfinancial support from Napp, personal fees from Novartis, personal fees and nonfinancial support from Astra Zeneca, personal fees and nonfinancial support from Boehringer Ingelheim, personal fees from Teva, and personal fees from Innovate UK, outside the submitted work. S.R. Johnson reports grants from Medical Research Council, during the conduct of the study, and nonfinancial support from Boehringer-Ingelheim, outside the submitted work. C.E. Brightling reports grants from AirPROM FP7, grants from Asthma UK, and grants from National Institute for Health Research Biomedical Research Centre, during the conduct of the study. D.E. Shaw reports grants from GlaxoSmithKline, during the conduct of the study, and grants from GlaxoSmithKline, outside the submitted work. G.H. Koppelman reports grants from TEVA the Netherlands, Vertex, and Stichting Astma Bestrijding, outside the submitted work, and advisory board fees from GlaxoSmithKline and PureIMS, outside the submitted work. M.C. Nawijn reports grants from GlaxoSmithKline, outside the submitted work. I. Sayers reports grants from GlaxoSmithKline and grants from Anaptsbio Inc, outside the submitted work. R. Chaudhuri reports personal fees and nonfinancial support from AstraZeneca, personal fees from GlaxoSmithKline, personal fees from Teva Pharmaceuticals, and personal fees and nonfinancial support from Novartis, outside the submitted work. A.V. Benest and D.O. Bates are supported by British Heart Foundation grant. A.V. Benest is supported by a Royal Society Project grant RGS∖R1∖191221. The remaining authors have declared that no conflict of interest exists. Publisher Copyright: © 2020

Keywords: IL33 SNPs, asthma phenotypes, bronchial epithelium, eQTL, functional translation

Local EPrints ID: 439635

URI: http://eprints.soton.ac.uk/id/eprint/439635

DOI: doi:10.1016/j.jaci.2020.04.051

ISSN: 0091-6749

PURE UUID: 638066a3-cb7d-40d6-a42e-d5bb6f84c9b5

ORCID for J. Holloway: orcid.org/0000-0001-9998-0464

Date deposited: 28 Apr 2020 16:35

Last modified: 17 Mar 2024 05:30