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Non-alcoholic fatty liver disease and childhood obesity

Non-alcoholic fatty liver disease and childhood obesity
Non-alcoholic fatty liver disease and childhood obesity

Non-alcoholic fatty liver disease (NAFLD) in children and adolescents has an estimated prevalence of 36.1% in the context of obesity. This figure is anticipated to increase in conjunction with the global obesity epidemic. Worryingly, NAFLD in childhood persisting into adulthood is likely to be harmful, contributing to significant hepatic and extrahepatic morbidities. Early disease detection is required, although the optimum timing, frequency and mode of screening remains undetermined. While the efficacy of several medications, antioxidants, fatty acid supplements and probiotics has been investigated in children, healthy eating and physical activity remain the only prevention and treatment strategies for paediatric NAFLD. This short review discusses the epidemiology, diagnosis, pathogenesis and management of NAFLD in childhood obesity.

endocrinology; epidemiology; obesity, non-alcoholic fatty liver
0003-9888
3-8
Shaunak, M.
9ab1fda1-7a2a-4512-a107-98bcd19cf4c2
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Davis, N.
55aa0195-3d0c-40e6-ad1e-c79bf674429d
Afolabi, Paul
757e7f01-664c-493e-bc51-c6a2c933dc22
Faust, Saul
f97df780-9f9b-418e-b349-7adf63e150c1
Davies, Justin
9f18fcad-f488-4c72-ac23-c154995443a9
Shaunak, M.
9ab1fda1-7a2a-4512-a107-98bcd19cf4c2
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Davis, N.
55aa0195-3d0c-40e6-ad1e-c79bf674429d
Afolabi, Paul
757e7f01-664c-493e-bc51-c6a2c933dc22
Faust, Saul
f97df780-9f9b-418e-b349-7adf63e150c1
Davies, Justin
9f18fcad-f488-4c72-ac23-c154995443a9

Shaunak, M., Byrne, Christopher, Davis, N., Afolabi, Paul, Faust, Saul and Davies, Justin (2021) Non-alcoholic fatty liver disease and childhood obesity. Archives of Disease in Childhood, 106 (1), 3-8, [https://doi.org/10.1136/archdischild-2019-318063]. (doi:10.1136/archdischild-2019-318063).

Record type: Review

Abstract

Non-alcoholic fatty liver disease (NAFLD) in children and adolescents has an estimated prevalence of 36.1% in the context of obesity. This figure is anticipated to increase in conjunction with the global obesity epidemic. Worryingly, NAFLD in childhood persisting into adulthood is likely to be harmful, contributing to significant hepatic and extrahepatic morbidities. Early disease detection is required, although the optimum timing, frequency and mode of screening remains undetermined. While the efficacy of several medications, antioxidants, fatty acid supplements and probiotics has been investigated in children, healthy eating and physical activity remain the only prevention and treatment strategies for paediatric NAFLD. This short review discusses the epidemiology, diagnosis, pathogenesis and management of NAFLD in childhood obesity.

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Paediatric NAFLD Review Final - Accepted Manuscript
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Figure 1 (23.04.20) - Accepted Manuscript
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More information

Accepted/In Press date: 25 April 2020
e-pub ahead of print date: 14 May 2020
Published date: 1 January 2021
Additional Information: © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Keywords: endocrinology; epidemiology; obesity, non-alcoholic fatty liver

Identifiers

Local EPrints ID: 439700
URI: http://eprints.soton.ac.uk/id/eprint/439700
ISSN: 0003-9888
PURE UUID: 1db31f04-bbe3-456a-9829-ddf1b2955534
ORCID for Christopher Byrne: ORCID iD orcid.org/0000-0001-6322-7753
ORCID for Paul Afolabi: ORCID iD orcid.org/0000-0002-0553-1578
ORCID for Saul Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 30 Apr 2020 16:30
Last modified: 22 Nov 2021 08:07

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Contributors

Author: M. Shaunak
Author: N. Davis
Author: Paul Afolabi ORCID iD
Author: Saul Faust ORCID iD
Author: Justin Davies

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