Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers
Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers
Parkinson's disease (PD) is a chronic disorder that presents a range of premotor signs, such as sleep disturbances and cognitive decline, which are key non-motor features of the disease. Increasing evidence of a possible association between sleep disruption and the neurodegenerative process suggests that sleep impairment could produce a detectable metabolic signature on the disease. In order to integrate neurocognitive and metabolic parameters, we performed untargeted and targeted metabolic profiling of the rotenone PD model in a chronic sleep restriction (SR) (6 h/day for 21 days) condition. We found that SR combined with PD altered several behavioural (reversal of locomotor activity impairment; cognitive impairment; delay of rest-activity rhythm) and metabolic parameters (branched-chain amino acids, tryptophan pathway, phenylalanine, and lipoproteins, pointing to mitochondrial impairment). If combined, our results bring a plethora of parameters that represents reliable early-phase PD biomarkers which can easily be measured and could be translated to human studies.
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Fagotti, Juliane
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Targa, Adriano D.S.
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Rodrigues, Lais S.
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Noseda, Ana Carolina D.
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Dorieux, Flávia W.C.
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Scarante, Franciele F.
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Ilkiw, Jessica L.
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Louzada, Fernando M.
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Chowdhury, Namrata R.
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van der Veen, Daan R.
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Middleton, Benita
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Pennings, Jeroen L.A.
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Swann, Jonathan R.
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Skene, Debra J.
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Lima, Marcelo M.S.
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2019
Fagotti, Juliane
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Targa, Adriano D.S.
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Rodrigues, Lais S.
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Noseda, Ana Carolina D.
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Dorieux, Flávia W.C.
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Scarante, Franciele F.
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Ilkiw, Jessica L.
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Louzada, Fernando M.
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Chowdhury, Namrata R.
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van der Veen, Daan R.
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Middleton, Benita
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Pennings, Jeroen L.A.
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Swann, Jonathan R.
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Skene, Debra J.
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Lima, Marcelo M.S.
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Fagotti, Juliane, Targa, Adriano D.S., Rodrigues, Lais S., Noseda, Ana Carolina D., Dorieux, Flávia W.C., Scarante, Franciele F., Ilkiw, Jessica L., Louzada, Fernando M., Chowdhury, Namrata R., van der Veen, Daan R., Middleton, Benita, Pennings, Jeroen L.A., Swann, Jonathan R., Skene, Debra J. and Lima, Marcelo M.S.
(2019)
Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers.
Scientific Reports, 9 (1), , [1898].
(doi:10.1038/s41598-018-37657-6).
Abstract
Parkinson's disease (PD) is a chronic disorder that presents a range of premotor signs, such as sleep disturbances and cognitive decline, which are key non-motor features of the disease. Increasing evidence of a possible association between sleep disruption and the neurodegenerative process suggests that sleep impairment could produce a detectable metabolic signature on the disease. In order to integrate neurocognitive and metabolic parameters, we performed untargeted and targeted metabolic profiling of the rotenone PD model in a chronic sleep restriction (SR) (6 h/day for 21 days) condition. We found that SR combined with PD altered several behavioural (reversal of locomotor activity impairment; cognitive impairment; delay of rest-activity rhythm) and metabolic parameters (branched-chain amino acids, tryptophan pathway, phenylalanine, and lipoproteins, pointing to mitochondrial impairment). If combined, our results bring a plethora of parameters that represents reliable early-phase PD biomarkers which can easily be measured and could be translated to human studies.
Text
s41598-018-37657-6
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Accepted/In Press date: 6 December 2018
e-pub ahead of print date: 13 February 2019
Published date: 2019
Identifiers
Local EPrints ID: 439831
URI: http://eprints.soton.ac.uk/id/eprint/439831
ISSN: 2045-2322
PURE UUID: 1c1f60d3-a55d-4b1a-9c00-5f5ee576efdd
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Date deposited: 05 May 2020 16:30
Last modified: 17 Mar 2024 04:00
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Contributors
Author:
Juliane Fagotti
Author:
Adriano D.S. Targa
Author:
Lais S. Rodrigues
Author:
Ana Carolina D. Noseda
Author:
Flávia W.C. Dorieux
Author:
Franciele F. Scarante
Author:
Jessica L. Ilkiw
Author:
Fernando M. Louzada
Author:
Namrata R. Chowdhury
Author:
Daan R. van der Veen
Author:
Benita Middleton
Author:
Jeroen L.A. Pennings
Author:
Debra J. Skene
Author:
Marcelo M.S. Lima
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