Droplet-based microfluidics: Formation, detection and analytical characterization
Droplet-based microfluidics: Formation, detection and analytical characterization
Microfluidics has become attractive in the recent decade due to its ability to offer low-cost, robust and miniaturized assays at a small cost as compared to the bulk tests. The credit mainly goes to the advancement in miniaturization technologies allowing cheaper and faster fabrications of microfluidics devices. Continuous microfluidics has been developed for the study of chemical and biochemical reactions inside microchannels, but the Taylor dispersion, sample contamination on the channel walls and less mixing efficiency has offset the benefits of microfluidics. Droplet-based microfluidics, on the other hand, has emerged as a powerful tool to encapsulate chemical and biological samples in discrete droplets and has generated a diverse array of applications including biochemical reactions, chemical synthesis, drug delivery, and point-of-care diagnostics. This review will outline the droplet generation, mixing, merging and detection methods, and characterization of droplet contents.
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa
September 2019
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa
Hassan, Sammer-Ul, Zhang, Xunli and Niu, Xize
(2019)
Droplet-based microfluidics: Formation, detection and analytical characterization.
Research & Development in Material Science, 11 (5).
(doi:10.31031/RDMS.2019.11.000774).
Abstract
Microfluidics has become attractive in the recent decade due to its ability to offer low-cost, robust and miniaturized assays at a small cost as compared to the bulk tests. The credit mainly goes to the advancement in miniaturization technologies allowing cheaper and faster fabrications of microfluidics devices. Continuous microfluidics has been developed for the study of chemical and biochemical reactions inside microchannels, but the Taylor dispersion, sample contamination on the channel walls and less mixing efficiency has offset the benefits of microfluidics. Droplet-based microfluidics, on the other hand, has emerged as a powerful tool to encapsulate chemical and biological samples in discrete droplets and has generated a diverse array of applications including biochemical reactions, chemical synthesis, drug delivery, and point-of-care diagnostics. This review will outline the droplet generation, mixing, merging and detection methods, and characterization of droplet contents.
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Accepted/In Press date: 25 September 2019
e-pub ahead of print date: 25 September 2019
Published date: September 2019
Identifiers
Local EPrints ID: 440665
URI: http://eprints.soton.ac.uk/id/eprint/440665
ISSN: 2576-8840
PURE UUID: d1809314-9e44-4219-99f8-61bd71b7c20e
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Date deposited: 13 May 2020 16:33
Last modified: 17 Mar 2024 03:10
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