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Droplet-interfaced separations as an emerging tool for high-throughput microchip electrophoresis

Droplet-interfaced separations as an emerging tool for high-throughput microchip electrophoresis
Droplet-interfaced separations as an emerging tool for high-throughput microchip electrophoresis
Electrophoresis is a powerful analytical separation technique to analyses biological sample fragments such as nucleic acids, biomarkers, proteins, enzymes etc. Microchip electrophoresis (MCE) is a miniaturised form of electrophoresis and offers fast, robust and low-cost analyses and portability. However, the current format of MCE operates only in the single channel, which limits the throughput of the separations. Droplet-based microfluidics, on the other hand, offers simplicity, robustness and multiplicity in microchannels. Therefore, it has a great potential for droplet-based high throughput electrophoretic separations of DNA fragments, proteins and biomarkers from biofluids such as saliva, blood, dialysate etc. and the ease of operational procedures could further lead this for the Point-of-Care (POC) diagnostics in healthcare
2576-8816
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa
Hassan, Sammer-Ul
8a5ae3f1-3451-4093-879e-85f40953da8b
Zhang, Xunli
d7cf1181-3276-4da1-9150-e212b333abb1
Niu, Xize
f3d964fb-23b4-45db-92fe-02426e4e76fa

Hassan, Sammer-Ul, Zhang, Xunli and Niu, Xize (2019) Droplet-interfaced separations as an emerging tool for high-throughput microchip electrophoresis. Research in Medical & Engineering Sciences, 8 (1). (doi:10.31031/RMES.2019.08.000679).

Record type: Review

Abstract

Electrophoresis is a powerful analytical separation technique to analyses biological sample fragments such as nucleic acids, biomarkers, proteins, enzymes etc. Microchip electrophoresis (MCE) is a miniaturised form of electrophoresis and offers fast, robust and low-cost analyses and portability. However, the current format of MCE operates only in the single channel, which limits the throughput of the separations. Droplet-based microfluidics, on the other hand, offers simplicity, robustness and multiplicity in microchannels. Therefore, it has a great potential for droplet-based high throughput electrophoretic separations of DNA fragments, proteins and biomarkers from biofluids such as saliva, blood, dialysate etc. and the ease of operational procedures could further lead this for the Point-of-Care (POC) diagnostics in healthcare

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More information

Accepted/In Press date: 1 August 2019
e-pub ahead of print date: 1 August 2019

Identifiers

Local EPrints ID: 440671
URI: http://eprints.soton.ac.uk/id/eprint/440671
ISSN: 2576-8816
PURE UUID: 34420de5-80d8-46ef-81c6-98f70830f264
ORCID for Sammer-Ul Hassan: ORCID iD orcid.org/0000-0002-0319-5814
ORCID for Xunli Zhang: ORCID iD orcid.org/0000-0002-4375-1571

Catalogue record

Date deposited: 13 May 2020 16:34
Last modified: 07 Oct 2020 02:02

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