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Change in modifiable maternal characteristics and behaviours between consecutive pregnancies and offspring adiposity: a systematic review

Change in modifiable maternal characteristics and behaviours between consecutive pregnancies and offspring adiposity: a systematic review
Change in modifiable maternal characteristics and behaviours between consecutive pregnancies and offspring adiposity: a systematic review
Causal evidence links modifiable maternal exposures during the periconceptional period with offspring obesity. The interconception period may be an important time to intervene. We systematically identified studies examining change in modifiable maternal exposures between pregnancies and offspring adiposity. We searched for longitudinal studies published between 1990 and 2019, which included measurements taken on at least two occasions in the period from 1 year prior to the conception of the first birth to the time of the second birth, and which included a measure of adiposity in second, or higher order, siblings. Age, ethnicity and genetics were not considered modifiable; all other factors including length of the interpregnancy interval were. Eleven studies satisfied the inclusion criteria. Higher interpregnancy weight gain or loss, maternal smoking inception, mothers smoking in their first pregnancy and quitting, increasing the number of cigarettes smoked and longer interpregnancy intervals were positively associated with adiposity in second or higher order children. Vaginal birth after caesarean delivery was protective. Further research is needed to ascertain whether the risk of adiposity is fixed based on first pregnancy exposures or if interpregnancy change alters the risk for a subsequent child. This can inform the type and effectiveness of interventions for mothers prior to a subsequent pregnancy.
adiposity, childhood, interpregnancy, obesity
1467-7881
Taylor, Elizabeth
880bd662-b8bb-46a2-8db1-7fe31bd540ae
Wilding, Sam
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Ziauddeen, Nida
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Godfrey, Keith
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Berrington, Ann
bd0fc093-310d-4236-8126-ca0c7eb9ddde
Alwan, Nisreen
0d37b320-f325-4ed3-ba51-0fe2866d5382
Taylor, Elizabeth
880bd662-b8bb-46a2-8db1-7fe31bd540ae
Wilding, Sam
a026cae1-cc72-49b5-a52b-ec1d931d72e1
Ziauddeen, Nida
8b233a4a-9763-410b-90c7-df5c7d1a26e4
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Berrington, Ann
bd0fc093-310d-4236-8126-ca0c7eb9ddde
Alwan, Nisreen
0d37b320-f325-4ed3-ba51-0fe2866d5382

Taylor, Elizabeth, Wilding, Sam, Ziauddeen, Nida, Godfrey, Keith, Berrington, Ann and Alwan, Nisreen (2020) Change in modifiable maternal characteristics and behaviours between consecutive pregnancies and offspring adiposity: a systematic review. Obesity Reviews, 21 (11), [e13048]. (doi:10.1111/obr.13048).

Record type: Article

Abstract

Causal evidence links modifiable maternal exposures during the periconceptional period with offspring obesity. The interconception period may be an important time to intervene. We systematically identified studies examining change in modifiable maternal exposures between pregnancies and offspring adiposity. We searched for longitudinal studies published between 1990 and 2019, which included measurements taken on at least two occasions in the period from 1 year prior to the conception of the first birth to the time of the second birth, and which included a measure of adiposity in second, or higher order, siblings. Age, ethnicity and genetics were not considered modifiable; all other factors including length of the interpregnancy interval were. Eleven studies satisfied the inclusion criteria. Higher interpregnancy weight gain or loss, maternal smoking inception, mothers smoking in their first pregnancy and quitting, increasing the number of cigarettes smoked and longer interpregnancy intervals were positively associated with adiposity in second or higher order children. Vaginal birth after caesarean delivery was protective. Further research is needed to ascertain whether the risk of adiposity is fixed based on first pregnancy exposures or if interpregnancy change alters the risk for a subsequent child. This can inform the type and effectiveness of interventions for mothers prior to a subsequent pregnancy.

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Accepted/In Press date: 21 April 2020
e-pub ahead of print date: 29 May 2020
Published date: 1 November 2020
Additional Information: Funding Information: This research is supported by an NIHR Southampton Biomedical Research Centre and University of Southampton Primary Care, Population Sciences and Medical Education PhD studentship to E. J. T. and an Academy of Medical Sciences and Wellcome Trust grant to N.A.A. (Grant AMS_HOP0011060). K. M. G. is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator (NF‐SI‐0515‐10042), NIHR Southampton 1000DaysPlus Global Nutrition Research Group) and NIHR Southampton Biomedical Research Centre), the European Union (Erasmus+ Programme Early Nutrition eAcademy Southeast Asia‐573651‐EPP‐1‐2016‐1‐DE‐EPPKA2‐CBHE‐JP), the US National Institute On Aging of the National Institutes of Health (Award No. U24AG047867) and the UK ESRC and BBSRC (Award No. ES/M00919X/1) and the British Heart Foundation (RG/15/17/3174). The research funders had no input on research design or on manuscript drafting. The authors wish to thank Paula Sands (Site and Research Engagement Librarian, University of Southampton) for her contribution to the search design. Funding Information: K. M. G. has received reimbursement for speaking at conferences sponsored by companies selling nutritional products and is part of an academic consortium that has received research funding from BenevolentAIBio Ltd., Abbott Nutrition, Nestec and Danone. All other authors declare no conflicts of interest. Publisher Copyright: © 2020 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
Keywords: adiposity, childhood, interpregnancy, obesity

Identifiers

Local EPrints ID: 440700
URI: http://eprints.soton.ac.uk/id/eprint/440700
ISSN: 1467-7881
PURE UUID: bc79ad53-faa6-4a32-8487-2f9adedd6eef
ORCID for Elizabeth Taylor: ORCID iD orcid.org/0000-0002-7680-2865
ORCID for Sam Wilding: ORCID iD orcid.org/0000-0003-4184-2821
ORCID for Nida Ziauddeen: ORCID iD orcid.org/0000-0002-8964-5029
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Ann Berrington: ORCID iD orcid.org/0000-0002-1683-6668
ORCID for Nisreen Alwan: ORCID iD orcid.org/0000-0002-4134-8463

Catalogue record

Date deposited: 13 May 2020 17:06
Last modified: 23 Jul 2022 04:53

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Contributors

Author: Elizabeth Taylor ORCID iD
Author: Sam Wilding ORCID iD
Author: Nida Ziauddeen ORCID iD
Author: Keith Godfrey ORCID iD
Author: Ann Berrington ORCID iD
Author: Nisreen Alwan ORCID iD

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