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CNS inflammatory vasculopathy with anti-myelin oligodendrocyte glycoprotein antibodies in COVID-19

CNS inflammatory vasculopathy with anti-myelin oligodendrocyte glycoprotein antibodies in COVID-19
CNS inflammatory vasculopathy with anti-myelin oligodendrocyte glycoprotein antibodies in COVID-19
We present the case of a 44 year old female patient with a CNS inflammatory condition secondary to COVID-19, characterized by marked perivascular enhancement on MRI, negative SARS-CoV-2 PCR in CSF, anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in serum, and rapid clinical and radiological recovery following treatment with intravenous methylprednisolone (IVMP) and plasma exchange (PLEX). We hypothesise that this unusual clinical and radiological presentation was caused by a combination of an anti-MOG antibody response and endothelial dysfunction accompanying COVID-19. The rapid clinical and radiological response to PLEX and IVMP was striking.
2332-7812
1-4
Pinto, Ashwin A.
2815102d-0779-4005-9e16-ec261510314d
Carroll, Liam S.
ebc4be38-fa45-45dc-84ae-5fbafeda1f29
Nar, Vijay
8889e54a-6c2b-439b-84c4-6e0540bff853
Varatharaj, Aravinthan
33d833af-9459-4b21-8489-ce9c0b6a09e0
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Pinto, Ashwin A.
2815102d-0779-4005-9e16-ec261510314d
Carroll, Liam S.
ebc4be38-fa45-45dc-84ae-5fbafeda1f29
Nar, Vijay
8889e54a-6c2b-439b-84c4-6e0540bff853
Varatharaj, Aravinthan
33d833af-9459-4b21-8489-ce9c0b6a09e0
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b

Pinto, Ashwin A., Carroll, Liam S., Nar, Vijay, Varatharaj, Aravinthan and Galea, Ian (2020) CNS inflammatory vasculopathy with anti-myelin oligodendrocyte glycoprotein antibodies in COVID-19. Neurology: Neuroimmunology & Neuroinflammation, 7 (5), 1-4. (doi:10.1212/NXI.0000000000000813).

Record type: Article

Abstract

We present the case of a 44 year old female patient with a CNS inflammatory condition secondary to COVID-19, characterized by marked perivascular enhancement on MRI, negative SARS-CoV-2 PCR in CSF, anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in serum, and rapid clinical and radiological recovery following treatment with intravenous methylprednisolone (IVMP) and plasma exchange (PLEX). We hypothesise that this unusual clinical and radiological presentation was caused by a combination of an anti-MOG antibody response and endothelial dysfunction accompanying COVID-19. The rapid clinical and radiological response to PLEX and IVMP was striking.

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Accepted/In Press date: 26 May 2020
e-pub ahead of print date: 10 June 2020
Published date: September 2020

Identifiers

Local EPrints ID: 440723
URI: http://eprints.soton.ac.uk/id/eprint/440723
ISSN: 2332-7812
PURE UUID: c050c13a-adbc-4e26-8756-572e67cb683a
ORCID for Aravinthan Varatharaj: ORCID iD orcid.org/0000-0003-1629-5774
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

Catalogue record

Date deposited: 14 May 2020 16:31
Last modified: 26 Nov 2021 03:17

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Contributors

Author: Ashwin A. Pinto
Author: Liam S. Carroll
Author: Vijay Nar
Author: Ian Galea ORCID iD

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