Small talk: microbial metabolites involved in the signaling from microbiota to brain
Small talk: microbial metabolites involved in the signaling from microbiota to brain
The wealth of biotransformational capabilities encoded in the microbiome expose the host to an array of bioactive xenobiotic products. Several of these metabolites participate in the communication between the gastrointestinal tract and the central nervous system and have potential to modulate central physiological and pathological processes. This biochemical interplay can occur through various direct and indirect mechanisms. These include binding to host receptors in the brain, stimulation of the vagus nerve in the gut, alteration of central neurotransmission, and modulation of neuroinflammation. Here, the potential for short chain fatty acids, bile acids, neurotransmitters and other bioactive products of the microbiome to participate in the gut-brain axis will be reviewed.
99-106
Caspani, Giorgia
ca711d7a-4d4b-4b99-8550-db8ed3ad612e
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
October 2019
Caspani, Giorgia
ca711d7a-4d4b-4b99-8550-db8ed3ad612e
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Caspani, Giorgia and Swann, Jonathan
(2019)
Small talk: microbial metabolites involved in the signaling from microbiota to brain.
Current Opinion in Pharmacology, 48, .
(doi:10.1016/j.coph.2019.08.001).
Abstract
The wealth of biotransformational capabilities encoded in the microbiome expose the host to an array of bioactive xenobiotic products. Several of these metabolites participate in the communication between the gastrointestinal tract and the central nervous system and have potential to modulate central physiological and pathological processes. This biochemical interplay can occur through various direct and indirect mechanisms. These include binding to host receptors in the brain, stimulation of the vagus nerve in the gut, alteration of central neurotransmission, and modulation of neuroinflammation. Here, the potential for short chain fatty acids, bile acids, neurotransmitters and other bioactive products of the microbiome to participate in the gut-brain axis will be reviewed.
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e-pub ahead of print date: 14 September 2019
Published date: October 2019
Identifiers
Local EPrints ID: 440796
URI: http://eprints.soton.ac.uk/id/eprint/440796
ISSN: 1471-4892
PURE UUID: db3dc4be-d3d4-4449-b9cb-2278467d7220
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Date deposited: 18 May 2020 16:59
Last modified: 17 Mar 2024 04:00
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Author:
Giorgia Caspani
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