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Characterizing the biochemical response to Schistosoma mansoni infection and treatment with Praziquantel in preschool and school aged children

Characterizing the biochemical response to Schistosoma mansoni infection and treatment with Praziquantel in preschool and school aged children
Characterizing the biochemical response to Schistosoma mansoni infection and treatment with Praziquantel in preschool and school aged children

Schistosomiasis is a widespread chronic neglected tropical disease prevalent mostly in children in under-resourced rural areas. Its pathological effects have been clinically characterized, yet the molecular-level effects are understudied. In this study, the biochemical effects of Schistosoma mansoni infection and praziquantel treatment were studied in 130 preschool aged and 159 school aged infected children and 11 noninfected children in Azaguié, Côte d'Ivoire. Urine samples were collected prior to receiving 20, 40, or 60 mg/kg of praziquantel or a placebo, as well as 24 h post-treatment, and at the 3-week follow up. Urinary metabolic phenotypes were measured using 1H NMR spectroscopy, and metabolic variation associated with S. mansoni infection and praziquantel administration was identified using multivariate statistical techniques. Discriminatory metabolic signatures were detected between heavily infected and noninfected children at baseline as well as according to the dose of praziquantel administered 24 h post treatment. These signatures were primarily associated with the metabolic activity of the gut microbiota, gut health and growth biomarkers and energy and liver metabolism. These analyses provide insights into the metabolic phenotype of schistosomiasis and treatment with praziquantel in two important demographics.

Case-Control Studies, Child, Child, Preschool, Dose-Response Relationship, Drug, Humans, Metabolome, Praziquantel/metabolism, Proton Magnetic Resonance Spectroscopy, Schistosomiasis mansoni/drug therapy
1535-3893
2028-2033
Panic, Gordana
e78534c3-1e89-4161-9128-45518d4279de
Coulibaly, Jean T.
f6628c42-c5d7-41e9-9f26-7950f7d4e4f1
Harvey, Nikita
e1a6ec74-7a81-44e6-8922-7e3a9842ad7f
Keiser, Jennifer
fb685e18-bbb9-483b-8251-c470950e9f2a
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Panic, Gordana
e78534c3-1e89-4161-9128-45518d4279de
Coulibaly, Jean T.
f6628c42-c5d7-41e9-9f26-7950f7d4e4f1
Harvey, Nikita
e1a6ec74-7a81-44e6-8922-7e3a9842ad7f
Keiser, Jennifer
fb685e18-bbb9-483b-8251-c470950e9f2a
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c

Panic, Gordana, Coulibaly, Jean T., Harvey, Nikita, Keiser, Jennifer and Swann, Jonathan (2018) Characterizing the biochemical response to Schistosoma mansoni infection and treatment with Praziquantel in preschool and school aged children. Journal of Proteome Research, 17 (6), 2028-2033. (doi:10.1021/acs.jproteome.7b00910).

Record type: Article

Abstract

Schistosomiasis is a widespread chronic neglected tropical disease prevalent mostly in children in under-resourced rural areas. Its pathological effects have been clinically characterized, yet the molecular-level effects are understudied. In this study, the biochemical effects of Schistosoma mansoni infection and praziquantel treatment were studied in 130 preschool aged and 159 school aged infected children and 11 noninfected children in Azaguié, Côte d'Ivoire. Urine samples were collected prior to receiving 20, 40, or 60 mg/kg of praziquantel or a placebo, as well as 24 h post-treatment, and at the 3-week follow up. Urinary metabolic phenotypes were measured using 1H NMR spectroscopy, and metabolic variation associated with S. mansoni infection and praziquantel administration was identified using multivariate statistical techniques. Discriminatory metabolic signatures were detected between heavily infected and noninfected children at baseline as well as according to the dose of praziquantel administered 24 h post treatment. These signatures were primarily associated with the metabolic activity of the gut microbiota, gut health and growth biomarkers and energy and liver metabolism. These analyses provide insights into the metabolic phenotype of schistosomiasis and treatment with praziquantel in two important demographics.

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More information

e-pub ahead of print date: 27 April 2018
Published date: 1 June 2018
Keywords: Case-Control Studies, Child, Child, Preschool, Dose-Response Relationship, Drug, Humans, Metabolome, Praziquantel/metabolism, Proton Magnetic Resonance Spectroscopy, Schistosomiasis mansoni/drug therapy

Identifiers

Local EPrints ID: 440819
URI: http://eprints.soton.ac.uk/id/eprint/440819
ISSN: 1535-3893
PURE UUID: 955a23d3-8a2e-4de7-9091-858c7ce2f439
ORCID for Jonathan Swann: ORCID iD orcid.org/0000-0002-6485-4529

Catalogue record

Date deposited: 19 May 2020 17:32
Last modified: 17 Mar 2024 04:00

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Contributors

Author: Gordana Panic
Author: Jean T. Coulibaly
Author: Nikita Harvey
Author: Jennifer Keiser
Author: Jonathan Swann ORCID iD

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