Organozirconium-mediated solution- and solid-phase synthesis of 3-benzyl pyrrolidines and other potentially neuroactive amines
Organozirconium-mediated solution- and solid-phase synthesis of 3-benzyl pyrrolidines and other potentially neuroactive amines
An efficient route to 3-benzylpyrrolidines using a zirconium-mediated cyclisation both in solution and on a solid support is reported. 3-Benzylidine-pyrrolidines, 3-aryl-pyrrolidines and 4-arylpiperidines were also synthesised.
zirconium, neuroactive, pyrrolidine, solid-phase, library
3314-3318
Hunter, Rupert A.
5c8736c6-7793-4e94-b91c-0807e3d175a7
Macfarlane, Donald P.S.
321775c5-d95d-4831-b5d9-534463c45185
Whitby, Richard J.
45632236-ab00-4ad0-a02d-6209043e818b
2006
Hunter, Rupert A.
5c8736c6-7793-4e94-b91c-0807e3d175a7
Macfarlane, Donald P.S.
321775c5-d95d-4831-b5d9-534463c45185
Whitby, Richard J.
45632236-ab00-4ad0-a02d-6209043e818b
Hunter, Rupert A., Macfarlane, Donald P.S. and Whitby, Richard J.
(2006)
Organozirconium-mediated solution- and solid-phase synthesis of 3-benzyl pyrrolidines and other potentially neuroactive amines.
Synlett, (19), .
(doi:10.1055/s-2006-951553).
Abstract
An efficient route to 3-benzylpyrrolidines using a zirconium-mediated cyclisation both in solution and on a solid support is reported. 3-Benzylidine-pyrrolidines, 3-aryl-pyrrolidines and 4-arylpiperidines were also synthesised.
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Published date: 2006
Keywords:
zirconium, neuroactive, pyrrolidine, solid-phase, library
Identifiers
Local EPrints ID: 44088
URI: http://eprints.soton.ac.uk/id/eprint/44088
ISSN: 0936-5214
PURE UUID: a7e6bcec-2ea4-4bc8-9dea-0ec234687dec
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Date deposited: 13 Feb 2007
Last modified: 16 Mar 2024 02:33
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Contributors
Author:
Rupert A. Hunter
Author:
Donald P.S. Macfarlane
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