L-rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake
L-rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake
Activation of free fatty acid receptor (FFAR)2 and FFAR3 via colonic short-chain fatty acids, particularly propionate, are postulated to explain observed inverse associations between dietary fiber intake and body weight. Propionate is reported as the predominant colonic fermentation product from l-rhamnose, a natural monosaccharide that resists digestion and absorption reaching the colon intact, while effects of long-chain inulin on appetite have not been extensively investigated. In this single-blind randomized crossover study, healthy unrestrained eaters (n = 13) ingested 25.5 g/d l-rhamnose, 22.4 g/d inulin or no supplement (control) alongside a standardized breakfast and lunch, following a 6-d run-in to investigate if appetite was inhibited. Postprandial qualitative appetite, breath hydrogen, and plasma glucose, insulin, triglycerides and non-esterified fatty acids were assessed for 420 min, then an ad libitum meal was provided. Significant treatment x time effects were found for postprandial insulin (P = 0.009) and non-esterified fatty acids (P = 0.046) with a significantly lower insulin response for l-rhamnose (P = 0.023) than control. No differences between treatments were found for quantitative and qualitative appetite measures, although significant treatment x time effects for meal desire (P = 0.008) and desire to eat sweet (P = 0.036) were found. Breath hydrogen was significantly higher with inulin (P = 0.001) and l-rhamnose (P = 0.009) than control, indicating colonic fermentation. These findings suggest l-rhamnose may inhibit postprandial insulin secretion, however neither l-rhamnose or inulin influenced appetite.
Adolescent, Adult, Appetite/drug effects, Blood Glucose/metabolism, Body Mass Index, Cholesterol, HDL/blood, Cholesterol, LDL/blood, Colon/drug effects, Cross-Over Studies, Dietary Carbohydrates/administration & dosage, Dietary Fats/administration & dosage, Dietary Fiber/administration & dosage, Dietary Proteins/administration & dosage, Dietary Supplements, Energy Intake, Fatty Acids, Nonesterified/blood, Female, Glucagon-Like Peptide 1/metabolism, Humans, Insulin/metabolism, Insulin Resistance, Insulin Secretion, Inulin/administration & dosage, Male, Middle Aged, Peptide YY/metabolism, Postprandial Period/drug effects, Propionates/blood, Receptors, Cell Surface/metabolism, Receptors, G-Protein-Coupled/metabolism, Rhamnose/administration & dosage, Single-Blind Method, Waist Circumference, Young Adult
142-149
Darzi, Julia
fa88626c-cd7f-48d2-9bf4-a381e14dd680
Frost, Gary S.
6a72e815-6bb1-45be-ae63-2d7aaebee3f6
Swann, Jonathan R.
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Costabile, Adele
2f54d3f0-8414-4844-8296-e97f6097e09e
Robertson, M. Denise
cf2fcfb2-eeda-4c6e-9338-dd1f631c51ff
1 March 2016
Darzi, Julia
fa88626c-cd7f-48d2-9bf4-a381e14dd680
Frost, Gary S.
6a72e815-6bb1-45be-ae63-2d7aaebee3f6
Swann, Jonathan R.
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Costabile, Adele
2f54d3f0-8414-4844-8296-e97f6097e09e
Robertson, M. Denise
cf2fcfb2-eeda-4c6e-9338-dd1f631c51ff
Darzi, Julia, Frost, Gary S., Swann, Jonathan R., Costabile, Adele and Robertson, M. Denise
(2016)
L-rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake.
Appetite, 98, .
(doi:10.1016/j.appet.2015.12.011).
Abstract
Activation of free fatty acid receptor (FFAR)2 and FFAR3 via colonic short-chain fatty acids, particularly propionate, are postulated to explain observed inverse associations between dietary fiber intake and body weight. Propionate is reported as the predominant colonic fermentation product from l-rhamnose, a natural monosaccharide that resists digestion and absorption reaching the colon intact, while effects of long-chain inulin on appetite have not been extensively investigated. In this single-blind randomized crossover study, healthy unrestrained eaters (n = 13) ingested 25.5 g/d l-rhamnose, 22.4 g/d inulin or no supplement (control) alongside a standardized breakfast and lunch, following a 6-d run-in to investigate if appetite was inhibited. Postprandial qualitative appetite, breath hydrogen, and plasma glucose, insulin, triglycerides and non-esterified fatty acids were assessed for 420 min, then an ad libitum meal was provided. Significant treatment x time effects were found for postprandial insulin (P = 0.009) and non-esterified fatty acids (P = 0.046) with a significantly lower insulin response for l-rhamnose (P = 0.023) than control. No differences between treatments were found for quantitative and qualitative appetite measures, although significant treatment x time effects for meal desire (P = 0.008) and desire to eat sweet (P = 0.036) were found. Breath hydrogen was significantly higher with inulin (P = 0.001) and l-rhamnose (P = 0.009) than control, indicating colonic fermentation. These findings suggest l-rhamnose may inhibit postprandial insulin secretion, however neither l-rhamnose or inulin influenced appetite.
This record has no associated files available for download.
More information
Accepted/In Press date: 14 December 2015
e-pub ahead of print date: 17 December 2015
Published date: 1 March 2016
Keywords:
Adolescent, Adult, Appetite/drug effects, Blood Glucose/metabolism, Body Mass Index, Cholesterol, HDL/blood, Cholesterol, LDL/blood, Colon/drug effects, Cross-Over Studies, Dietary Carbohydrates/administration & dosage, Dietary Fats/administration & dosage, Dietary Fiber/administration & dosage, Dietary Proteins/administration & dosage, Dietary Supplements, Energy Intake, Fatty Acids, Nonesterified/blood, Female, Glucagon-Like Peptide 1/metabolism, Humans, Insulin/metabolism, Insulin Resistance, Insulin Secretion, Inulin/administration & dosage, Male, Middle Aged, Peptide YY/metabolism, Postprandial Period/drug effects, Propionates/blood, Receptors, Cell Surface/metabolism, Receptors, G-Protein-Coupled/metabolism, Rhamnose/administration & dosage, Single-Blind Method, Waist Circumference, Young Adult
Identifiers
Local EPrints ID: 440892
URI: http://eprints.soton.ac.uk/id/eprint/440892
ISSN: 0195-6663
PURE UUID: ab67d35f-bdaf-4951-82f3-0f75fffa2d20
Catalogue record
Date deposited: 21 May 2020 16:33
Last modified: 17 Mar 2024 04:00
Export record
Altmetrics
Contributors
Author:
Julia Darzi
Author:
Gary S. Frost
Author:
Adele Costabile
Author:
M. Denise Robertson
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
