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Salivary uric acid as a predictive test of pre‐eclampsia, pregnancy‐induced hypertension and preterm delivery: a pilot study

Salivary uric acid as a predictive test of pre‐eclampsia, pregnancy‐induced hypertension and preterm delivery: a pilot study
Salivary uric acid as a predictive test of pre‐eclampsia, pregnancy‐induced hypertension and preterm delivery: a pilot study
ABSTRACT Introduction There remains a need for a non‐invasive, low cost and easily accessible way of identifying women at risk of developing hypertensive disorders in pregnancy. This study evaluated the predictive value of longitudinal salivary uric acid measurement. Material and methods Pregnant women (N = 137) from 20 weeks of gestation were recruited at St. Richards Hospital, Chichester, UK, for this prospective cohort study. Weekly samples of salivary uric acid were analyzed until delivery. Information regarding pregnancy and labor were obtained from the patient’s record after delivery. Independent t‐tests were used to compare mean levels of salivary uric acid in women with hypertensive complications and adverse fetal outcomes to women with normal pregnancies. Main outcome measures were pre‐eclampsia, pregnancy‐induced hypertension, spontaneous preterm delivery and babies small‐for‐gestational‐age. Results From 21 weeks of gestation until delivery, levels of salivary uric acid increased significantly in women who subsequently developed pre‐eclampsia and pregnancy‐induced hypertension compared to women with normal pregnancies (pre‐eclampsia (mean at gestational age 21‐24(CI 95%) (mean GA21‐24): 108(63;185) µmol/L vs 47(39;55) µmol/L; P=0.005)), pregnancy‐induced hypertension(mean GA21‐24: 118(54;258) µmol/L vs 47(39;55) µmol/L; P=0.004). In women who had spontaneous preterm delivery, salivary uric acid levels increased significantly from 29‐32 weeks of gestation compared to women with normal pregnancies(mean GA29‐32: 112(57;221) µmol/L vs 59(50;71) µmol/L; P=0.04). In women who had babies small‐for‐gestational‐age < 10th percentile and small‐for‐gestational‐age < 3rd percentile, differences in salivary uric acid levels were insignificant. Conclusions Elevated levels of salivary uric acid precede the onset of pre‐eclampsia, pregnancy‐induced hypertension and preterm delivery. Salivary uric acid may prove to be an early biomarker of hypertensive complications of pregnancy and spontaneous preterm delivery.
hypertensive disorders in pregnancy, preeclampsia, pregnancy-induced hypertension, preterm delivery, uric acid
0001-6349
1339-1345
Püschl, Ida Catharina
5a38e9d6-3410-4060-86fd-491d8b194fbc
Bonde, Lisbeth
9abd8f99-a168-481d-b86c-2dd8f96e9012
Reading, Isabel
6f832276-87b7-4a76-a9ed-b4b3df0a3f66
Maguire, Paddy
56eaae7f-aae5-4c79-8e9d-90c57cbe5c4b
Macklon, Nicholas
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Van Rijn, Bas
c958dfb5-2010-46de-a350-4903295ac340
Püschl, Ida Catharina
5a38e9d6-3410-4060-86fd-491d8b194fbc
Bonde, Lisbeth
9abd8f99-a168-481d-b86c-2dd8f96e9012
Reading, Isabel
6f832276-87b7-4a76-a9ed-b4b3df0a3f66
Maguire, Paddy
56eaae7f-aae5-4c79-8e9d-90c57cbe5c4b
Macklon, Nicholas
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Van Rijn, Bas
c958dfb5-2010-46de-a350-4903295ac340

Püschl, Ida Catharina, Bonde, Lisbeth, Reading, Isabel, Maguire, Paddy, Macklon, Nicholas and Van Rijn, Bas (2020) Salivary uric acid as a predictive test of pre‐eclampsia, pregnancy‐induced hypertension and preterm delivery: a pilot study. Acta Obstetricia et Gynecologica Scandinavica, 99 (10), 1339-1345. (doi:10.1111/aogs.13888).

Record type: Article

Abstract

ABSTRACT Introduction There remains a need for a non‐invasive, low cost and easily accessible way of identifying women at risk of developing hypertensive disorders in pregnancy. This study evaluated the predictive value of longitudinal salivary uric acid measurement. Material and methods Pregnant women (N = 137) from 20 weeks of gestation were recruited at St. Richards Hospital, Chichester, UK, for this prospective cohort study. Weekly samples of salivary uric acid were analyzed until delivery. Information regarding pregnancy and labor were obtained from the patient’s record after delivery. Independent t‐tests were used to compare mean levels of salivary uric acid in women with hypertensive complications and adverse fetal outcomes to women with normal pregnancies. Main outcome measures were pre‐eclampsia, pregnancy‐induced hypertension, spontaneous preterm delivery and babies small‐for‐gestational‐age. Results From 21 weeks of gestation until delivery, levels of salivary uric acid increased significantly in women who subsequently developed pre‐eclampsia and pregnancy‐induced hypertension compared to women with normal pregnancies (pre‐eclampsia (mean at gestational age 21‐24(CI 95%) (mean GA21‐24): 108(63;185) µmol/L vs 47(39;55) µmol/L; P=0.005)), pregnancy‐induced hypertension(mean GA21‐24: 118(54;258) µmol/L vs 47(39;55) µmol/L; P=0.004). In women who had spontaneous preterm delivery, salivary uric acid levels increased significantly from 29‐32 weeks of gestation compared to women with normal pregnancies(mean GA29‐32: 112(57;221) µmol/L vs 59(50;71) µmol/L; P=0.04). In women who had babies small‐for‐gestational‐age < 10th percentile and small‐for‐gestational‐age < 3rd percentile, differences in salivary uric acid levels were insignificant. Conclusions Elevated levels of salivary uric acid precede the onset of pre‐eclampsia, pregnancy‐induced hypertension and preterm delivery. Salivary uric acid may prove to be an early biomarker of hypertensive complications of pregnancy and spontaneous preterm delivery.

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aogs.13888 - Accepted Manuscript
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Accepted/In Press date: 29 April 2020
Published date: 29 April 2020
Keywords: hypertensive disorders in pregnancy, preeclampsia, pregnancy-induced hypertension, preterm delivery, uric acid

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Local EPrints ID: 440903
URI: http://eprints.soton.ac.uk/id/eprint/440903
ISSN: 0001-6349
PURE UUID: 96c7ee0c-417e-4e27-bd12-b82c399732b4
ORCID for Isabel Reading: ORCID iD orcid.org/0000-0002-1457-6532

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Date deposited: 22 May 2020 16:37
Last modified: 26 Nov 2021 05:18

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Contributors

Author: Ida Catharina Püschl
Author: Lisbeth Bonde
Author: Isabel Reading ORCID iD
Author: Paddy Maguire
Author: Nicholas Macklon
Author: Bas Van Rijn

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