The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Novel fiber lasers as excitation sources for photoacoustic tomography and microscopy

Novel fiber lasers as excitation sources for photoacoustic tomography and microscopy
Novel fiber lasers as excitation sources for photoacoustic tomography and microscopy
Two custom fibre lasers have been developed. One is designed for widefield photoacoustic tomography (PAT) and uses a custom drawn large core diameter fibre (100μm) to provide high pulse energies (5mJ). It also provides a variable pulse repetition frequency (100Hz-400Hz) and pulse duration (10-150ns) and is compact (of comparable dimensions to a desktop PC) and does not require external water cooling. This system was used to acquire in vivo images of the subcutaneous microvasculature in the human palm. The second laser is designed for Optical Resolution Photoacoustic Microscopy (OR-PAM) and provides a high quality beam (M2<1.1), pulse energies >1μJ with a pulse repetition frequency (PRF) up to 2MHz, and a 532nm emission wavelength. The high PRF of this laser was exploited for ultra-fast image acquisition. The compact size and enhanced functionality of these lasers offers a major opportunity to facilitate the translation of photoacoustic imaging to practical applications in medicine and biology.
SPIE
Allen, T.J.
441aa62d-00fd-40e0-9ac2-3049d81fd36a
Berendt, M.O.
8bbeb612-7bcf-4d49-8448-b3c0ef3cc362
Spurrell, J.
adfee145-3770-41b4-a434-a956d775dae0
Alam, S-U.
2b6bdbe5-ddcc-4a88-9057-299360b93435
Zhang, E.Z.
d98bcd67-bc62-4315-8df3-de57a6fa975c
Richardson, D.J.
ebfe1ff9-d0c2-4e52-b7ae-c1b13bccdef3
Beard, P.C.
cd0d1cb3-0cbf-4669-b744-d0750a6d7ef2
Allen, T.J.
441aa62d-00fd-40e0-9ac2-3049d81fd36a
Berendt, M.O.
8bbeb612-7bcf-4d49-8448-b3c0ef3cc362
Spurrell, J.
adfee145-3770-41b4-a434-a956d775dae0
Alam, S-U.
2b6bdbe5-ddcc-4a88-9057-299360b93435
Zhang, E.Z.
d98bcd67-bc62-4315-8df3-de57a6fa975c
Richardson, D.J.
ebfe1ff9-d0c2-4e52-b7ae-c1b13bccdef3
Beard, P.C.
cd0d1cb3-0cbf-4669-b744-d0750a6d7ef2

Allen, T.J., Berendt, M.O., Spurrell, J., Alam, S-U., Zhang, E.Z., Richardson, D.J. and Beard, P.C. (2016) Novel fiber lasers as excitation sources for photoacoustic tomography and microscopy. In Photons Plus Ultrasound: Imaging and Sensing 2016. vol. 9708, SPIE.. (doi:10.1117/12.2211733).

Record type: Conference or Workshop Item (Paper)

Abstract

Two custom fibre lasers have been developed. One is designed for widefield photoacoustic tomography (PAT) and uses a custom drawn large core diameter fibre (100μm) to provide high pulse energies (5mJ). It also provides a variable pulse repetition frequency (100Hz-400Hz) and pulse duration (10-150ns) and is compact (of comparable dimensions to a desktop PC) and does not require external water cooling. This system was used to acquire in vivo images of the subcutaneous microvasculature in the human palm. The second laser is designed for Optical Resolution Photoacoustic Microscopy (OR-PAM) and provides a high quality beam (M2<1.1), pulse energies >1μJ with a pulse repetition frequency (PRF) up to 2MHz, and a 532nm emission wavelength. The high PRF of this laser was exploited for ultra-fast image acquisition. The compact size and enhanced functionality of these lasers offers a major opportunity to facilitate the translation of photoacoustic imaging to practical applications in medicine and biology.

This record has no associated files available for download.

More information

Published date: 2016
Venue - Dates: SPIE Conference 9708: Photons Plus Ultrasound - Imaging and Sensing/Progress in Biomedical Optics and Imaging, 2016-02-14 - 2016-02-17

Identifiers

Local EPrints ID: 441176
URI: http://eprints.soton.ac.uk/id/eprint/441176
PURE UUID: c2b14f58-dbdc-4931-86da-0485b039f862
ORCID for D.J. Richardson: ORCID iD orcid.org/0000-0002-7751-1058

Catalogue record

Date deposited: 03 Jun 2020 16:32
Last modified: 07 Oct 2020 01:34

Export record

Altmetrics

Contributors

Author: T.J. Allen
Author: M.O. Berendt
Author: J. Spurrell
Author: S-U. Alam
Author: E.Z. Zhang
Author: D.J. Richardson ORCID iD
Author: P.C. Beard

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×