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Novel fiber lasers as excitation sources for photoacoustic tomography and microscopy

Novel fiber lasers as excitation sources for photoacoustic tomography and microscopy
Novel fiber lasers as excitation sources for photoacoustic tomography and microscopy
Two custom fibre lasers have been developed. One is designed for widefield photoacoustic tomography (PAT) and uses a custom drawn large core diameter fibre (100μm) to provide high pulse energies (5mJ). It also provides a variable pulse repetition frequency (100Hz-400Hz) and pulse duration (10-150ns) and is compact (of comparable dimensions to a desktop PC) and does not require external water cooling. This system was used to acquire in vivo images of the subcutaneous microvasculature in the human palm. The second laser is designed for Optical Resolution Photoacoustic Microscopy (OR-PAM) and provides a high quality beam (M2<1.1), pulse energies >1μJ with a pulse repetition frequency (PRF) up to 2MHz, and a 532nm emission wavelength. The high PRF of this laser was exploited for ultra-fast image acquisition. The compact size and enhanced functionality of these lasers offers a major opportunity to facilitate the translation of photoacoustic imaging to practical applications in medicine and biology.
SPIE
Allen, T.J.
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Berendt, M.O.
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Spurrell, J.
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Alam, S-U.
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Zhang, E.Z.
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Richardson, D.J.
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Beard, P.C.
cd0d1cb3-0cbf-4669-b744-d0750a6d7ef2
Allen, T.J.
441aa62d-00fd-40e0-9ac2-3049d81fd36a
Berendt, M.O.
8bbeb612-7bcf-4d49-8448-b3c0ef3cc362
Spurrell, J.
adfee145-3770-41b4-a434-a956d775dae0
Alam, S-U.
2b6bdbe5-ddcc-4a88-9057-299360b93435
Zhang, E.Z.
d98bcd67-bc62-4315-8df3-de57a6fa975c
Richardson, D.J.
ebfe1ff9-d0c2-4e52-b7ae-c1b13bccdef3
Beard, P.C.
cd0d1cb3-0cbf-4669-b744-d0750a6d7ef2

Allen, T.J., Berendt, M.O., Spurrell, J., Alam, S-U., Zhang, E.Z., Richardson, D.J. and Beard, P.C. (2016) Novel fiber lasers as excitation sources for photoacoustic tomography and microscopy. In Photons Plus Ultrasound: Imaging and Sensing 2016. vol. 9708, SPIE.. (doi:10.1117/12.2211733).

Record type: Conference or Workshop Item (Paper)

Abstract

Two custom fibre lasers have been developed. One is designed for widefield photoacoustic tomography (PAT) and uses a custom drawn large core diameter fibre (100μm) to provide high pulse energies (5mJ). It also provides a variable pulse repetition frequency (100Hz-400Hz) and pulse duration (10-150ns) and is compact (of comparable dimensions to a desktop PC) and does not require external water cooling. This system was used to acquire in vivo images of the subcutaneous microvasculature in the human palm. The second laser is designed for Optical Resolution Photoacoustic Microscopy (OR-PAM) and provides a high quality beam (M2<1.1), pulse energies >1μJ with a pulse repetition frequency (PRF) up to 2MHz, and a 532nm emission wavelength. The high PRF of this laser was exploited for ultra-fast image acquisition. The compact size and enhanced functionality of these lasers offers a major opportunity to facilitate the translation of photoacoustic imaging to practical applications in medicine and biology.

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More information

Published date: 2016
Venue - Dates: SPIE Conference 9708: Photons Plus Ultrasound - Imaging and Sensing/Progress in Biomedical Optics and Imaging, , San Francisco, CA, 2016-02-14 - 2016-02-17

Identifiers

Local EPrints ID: 441176
URI: http://eprints.soton.ac.uk/id/eprint/441176
PURE UUID: c2b14f58-dbdc-4931-86da-0485b039f862
ORCID for D.J. Richardson: ORCID iD orcid.org/0000-0002-7751-1058

Catalogue record

Date deposited: 03 Jun 2020 16:32
Last modified: 17 Mar 2024 02:36

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Contributors

Author: T.J. Allen
Author: M.O. Berendt
Author: J. Spurrell
Author: S-U. Alam
Author: E.Z. Zhang
Author: D.J. Richardson ORCID iD
Author: P.C. Beard

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