Dietary saturated fat and fibre and risk of cardiovascular disease and all-cause mortality among type 1 diabetic patients: the EURODIAB Prospective Complications Study
Dietary saturated fat and fibre and risk of cardiovascular disease and all-cause mortality among type 1 diabetic patients: the EURODIAB Prospective Complications Study
AIMS/HYPOTHESIS: Low adherence to recommendations for dietary saturated fatty acid (SFA) and fibre intake in patients with type 1 diabetes mellitus may heighten their increased risk of cardiovascular disease (CVD) and mortality. We examined the relationship of SFA and total, soluble and insoluble fibre with incident CVD and all-cause mortality in type 1 diabetic patients.
METHODS: A prospective cohort analysis was performed in 2,108 European type 1 diabetic patients aged 15-60 years who were free of CVD at baseline and enrolled in the EURODIAB Prospective Complications Study (51% male). Diet was assessed from a standardised 3 day dietary record. HR were calculated using Cox proportional hazards models.
RESULTS: During a mean follow-up of 7.3 years, 148 incident cases of fatal and non-fatal CVD and 46 all-cause deaths were documented. No statistically significant association was found between SFA and CVD and all-cause mortality. Total dietary fibre, per 5 g/day, was associated with lower all-cause mortality risk (HR 0.72; 95% CI 0.55, 0.95). This association was stronger for soluble fibre (per 5 g/day, HR 0.34; 95% CI 0.14, 0.80) compared with insoluble fibre (per 5 g/day; HR 0.66; 95% CI 0.45, 0.97). Similar results were found for the association with CVD.
CONCLUSIONS/INTERPRETATION: This study suggests that reported dietary SFA is not significantly associated with CVD and all-cause mortality in type 1 diabetic patients. On the contrary, higher dietary fibre consumption, especially soluble fibre, within the range commonly consumed by type 1 diabetic patients, may contribute to the prevention of CVD and all-cause mortality in type 1 diabetic patients.
Adolescent, Adult, Cardiovascular Diseases/blood, Diabetes Mellitus, Type 1/blood, Diabetic Angiopathies/blood, Diet Records, Dietary Fats/administration & dosage, Dietary Fiber/administration & dosage, Energy Intake, Europe/epidemiology, Female, Follow-Up Studies, Humans, Hypercholesterolemia/blood, Hypertension/blood, Male, Middle Aged, Patient Compliance, Patient Education as Topic, Prevalence, Prospective Studies, Risk Factors, Young Adult
2132-2141
Schoenaker, D A J M
84b96b87-4070-45a5-9777-5a1e4e45e818
Toeller, M
34db8b67-0eea-40b4-9ee5-fedcc7f58d02
Chaturvedi, N
2ca58292-9784-4321-9e5a-c59c50a2d574
Fuller, J H
1cc7f516-492a-4cd4-ad6b-854045ad81fe
Soedamah-Muthu, S S
a92e78f0-b28c-44f3-be86-e744fd004ff4
EURODIAB Prospective Complications Study Group
Schoenaker, D A J M
84b96b87-4070-45a5-9777-5a1e4e45e818
Toeller, M
34db8b67-0eea-40b4-9ee5-fedcc7f58d02
Chaturvedi, N
2ca58292-9784-4321-9e5a-c59c50a2d574
Fuller, J H
1cc7f516-492a-4cd4-ad6b-854045ad81fe
Soedamah-Muthu, S S
a92e78f0-b28c-44f3-be86-e744fd004ff4
EURODIAB Prospective Complications Study Group
(2012)
Dietary saturated fat and fibre and risk of cardiovascular disease and all-cause mortality among type 1 diabetic patients: the EURODIAB Prospective Complications Study.
Diabetologia, 55 (8), .
(doi:10.1007/s00125-012-2550-0).
Abstract
AIMS/HYPOTHESIS: Low adherence to recommendations for dietary saturated fatty acid (SFA) and fibre intake in patients with type 1 diabetes mellitus may heighten their increased risk of cardiovascular disease (CVD) and mortality. We examined the relationship of SFA and total, soluble and insoluble fibre with incident CVD and all-cause mortality in type 1 diabetic patients.
METHODS: A prospective cohort analysis was performed in 2,108 European type 1 diabetic patients aged 15-60 years who were free of CVD at baseline and enrolled in the EURODIAB Prospective Complications Study (51% male). Diet was assessed from a standardised 3 day dietary record. HR were calculated using Cox proportional hazards models.
RESULTS: During a mean follow-up of 7.3 years, 148 incident cases of fatal and non-fatal CVD and 46 all-cause deaths were documented. No statistically significant association was found between SFA and CVD and all-cause mortality. Total dietary fibre, per 5 g/day, was associated with lower all-cause mortality risk (HR 0.72; 95% CI 0.55, 0.95). This association was stronger for soluble fibre (per 5 g/day, HR 0.34; 95% CI 0.14, 0.80) compared with insoluble fibre (per 5 g/day; HR 0.66; 95% CI 0.45, 0.97). Similar results were found for the association with CVD.
CONCLUSIONS/INTERPRETATION: This study suggests that reported dietary SFA is not significantly associated with CVD and all-cause mortality in type 1 diabetic patients. On the contrary, higher dietary fibre consumption, especially soluble fibre, within the range commonly consumed by type 1 diabetic patients, may contribute to the prevention of CVD and all-cause mortality in type 1 diabetic patients.
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Schoenaker2012_Article_DietarySaturatedFatAndFibreAnd
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Accepted/In Press date: 29 February 2012
e-pub ahead of print date: 12 April 2012
Keywords:
Adolescent, Adult, Cardiovascular Diseases/blood, Diabetes Mellitus, Type 1/blood, Diabetic Angiopathies/blood, Diet Records, Dietary Fats/administration & dosage, Dietary Fiber/administration & dosage, Energy Intake, Europe/epidemiology, Female, Follow-Up Studies, Humans, Hypercholesterolemia/blood, Hypertension/blood, Male, Middle Aged, Patient Compliance, Patient Education as Topic, Prevalence, Prospective Studies, Risk Factors, Young Adult
Identifiers
Local EPrints ID: 441185
URI: http://eprints.soton.ac.uk/id/eprint/441185
ISSN: 0012-186X
PURE UUID: 8bf6eb5d-5dd4-40f2-9625-b2c63e6f812f
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Date deposited: 04 Jun 2020 16:30
Last modified: 17 Mar 2024 04:01
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Contributors
Author:
M Toeller
Author:
N Chaturvedi
Author:
J H Fuller
Author:
S S Soedamah-Muthu
Corporate Author: EURODIAB Prospective Complications Study Group
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