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Association between age at menarche and gestational diabetes mellitus: the Australian longitudinal study on women's health

Association between age at menarche and gestational diabetes mellitus: the Australian longitudinal study on women's health
Association between age at menarche and gestational diabetes mellitus: the Australian longitudinal study on women's health

In this study, we aimed to examine the association between age at menarche and gestational diabetes mellitus (GDM). Data were from 4,749 women participating in the Australian Longitudinal Study on Women's Health between 2000 and 2012. Age at menarche was reported at baseline in 2000 when women were aged 22-27 years. During 12 years of follow-up, information on GDM diagnosis was obtained for each live birth. Log-binomial regression analysis was used to estimate relative risks and 95% confidence intervals. Analyses adjusted for mother's highest completed educational qualification, nulliparity, polycystic ovary syndrome, physical activity, and body mass index. Mean age at menarche was 12.9 years (standard deviation, 1.4). A first diagnosis of GDM was reported by 357 women (7.5%). Compared with women with menarche at age 13 years, women who had their first menstruation at age ≤11 years had a 51% higher risk of developing GDM (95% confidence interval: 1.10, 2.07) after adjustment for GDM risk factors. Our findings indicate that a young age at menarche may identify women at higher risk of GDM. Further prospective studies are needed to confirm our findings and to elucidate the role of early-life exposures in age at menarche and subsequent GDM risk.

Adolescent, Adult, Age Factors, Australia/epidemiology, Body Mass Index, Child, Diabetes, Gestational/epidemiology, Educational Status, Exercise, Female, Humans, Longitudinal Studies, Menarche, Parity, Polycystic Ovary Syndrome/complications, Pregnancy, Risk, Risk Factors, Young Adult
0002-9262
554-561
Schoenaker, Danielle A J M
84b96b87-4070-45a5-9777-5a1e4e45e818
Mishra, Gita D
02143b82-e536-4915-9b30-3c86cbe1a1fe
Schoenaker, Danielle A J M
84b96b87-4070-45a5-9777-5a1e4e45e818
Mishra, Gita D
02143b82-e536-4915-9b30-3c86cbe1a1fe

Schoenaker, Danielle A J M and Mishra, Gita D (2017) Association between age at menarche and gestational diabetes mellitus: the Australian longitudinal study on women's health. American Journal of Epidemiology, 185 (7), 554-561. (doi:10.1093/aje/kww201).

Record type: Article

Abstract

In this study, we aimed to examine the association between age at menarche and gestational diabetes mellitus (GDM). Data were from 4,749 women participating in the Australian Longitudinal Study on Women's Health between 2000 and 2012. Age at menarche was reported at baseline in 2000 when women were aged 22-27 years. During 12 years of follow-up, information on GDM diagnosis was obtained for each live birth. Log-binomial regression analysis was used to estimate relative risks and 95% confidence intervals. Analyses adjusted for mother's highest completed educational qualification, nulliparity, polycystic ovary syndrome, physical activity, and body mass index. Mean age at menarche was 12.9 years (standard deviation, 1.4). A first diagnosis of GDM was reported by 357 women (7.5%). Compared with women with menarche at age 13 years, women who had their first menstruation at age ≤11 years had a 51% higher risk of developing GDM (95% confidence interval: 1.10, 2.07) after adjustment for GDM risk factors. Our findings indicate that a young age at menarche may identify women at higher risk of GDM. Further prospective studies are needed to confirm our findings and to elucidate the role of early-life exposures in age at menarche and subsequent GDM risk.

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More information

Accepted/In Press date: 18 April 2016
Published date: 1 April 2017
Keywords: Adolescent, Adult, Age Factors, Australia/epidemiology, Body Mass Index, Child, Diabetes, Gestational/epidemiology, Educational Status, Exercise, Female, Humans, Longitudinal Studies, Menarche, Parity, Polycystic Ovary Syndrome/complications, Pregnancy, Risk, Risk Factors, Young Adult

Identifiers

Local EPrints ID: 441200
URI: http://eprints.soton.ac.uk/id/eprint/441200
ISSN: 0002-9262
PURE UUID: 37bbd77c-e30b-43ca-8705-dce5a304da0c
ORCID for Danielle A J M Schoenaker: ORCID iD orcid.org/0000-0002-7652-990X

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Date deposited: 04 Jun 2020 16:31
Last modified: 09 Jan 2022 04:10

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Author: Gita D Mishra

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