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Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte docosahexaenoic acid and eicosapentaenoic acid to fish oil in healthy humans

Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte docosahexaenoic acid and eicosapentaenoic acid to fish oil in healthy humans
Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte docosahexaenoic acid and eicosapentaenoic acid to fish oil in healthy humans
EPA and DHA are required for normal cell function and can also induce health benefits. Oily fish are the main source of EPA and DHA for human consumption. However, food choices and concerns about the sustainability of marine fish stocks limit the effectiveness of dietary recommendations for EPA+DHA intakes. Seed oils from transgenic plants that contain EPA+DHA are a potential alternative source of EPA and DHA. To test this, the present study investigated whether dietary supplementation with transgenic Camelina sativa seed oil (CSO) that contained EPA and DHA was as effective as fish oil (FO) in increasing EPA and DHA concentrations when consumed as a dietary supplement in a blinded crossover study. Healthy men and women (n 31; age 53 (20-74) yrs) were randomised to consume 450 mg/day EPA+DHA provided either as either CSO or FO for 8 weeks, followed by 6 weeks washout and then switched to consuming the other test oil. Fasting venous blood samples were collected at the start and end of each supplementation period. Consuming the test oils significantly (P < 0.05) increased EPA and DHA concentrations in plasma triacylglycerol, phosphatidylcholine and cholesteryl esters. There were no significant differences between test oils in the increments of EPA and DHA. There was no significant difference between test oils in the increase in the proportion of erythrocyte EPA+DHA (CSO, 12%; P < 0.0001and FO, 8%; P = 0.02). Together these findings show that consuming CSO is as effective as FO for increasing EPA and DHA concentrations in humans.
Camelia sativa, Dietary Supplementation, Human Diet, Omega 3, Transgenic plant
0007-1145
1-9
West, Annette
c1923242-802f-4331-b743-31de45d3883c
Miles, Elizabeth
20332899-ecdb-4214-95bc-922dde36d416
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Han, Lihua
cd10f8f0-04f0-44ee-a52f-337b4cc8aad8
Napier, Johnathan
353a061e-80dd-4ee2-9407-9591818dde43
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Burdge, Graham
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
West, Annette
c1923242-802f-4331-b743-31de45d3883c
Miles, Elizabeth
20332899-ecdb-4214-95bc-922dde36d416
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Han, Lihua
cd10f8f0-04f0-44ee-a52f-337b4cc8aad8
Napier, Johnathan
353a061e-80dd-4ee2-9407-9591818dde43
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Burdge, Graham
09d60a07-8ca1-4351-9bf1-de6ffcfb2159

West, Annette, Miles, Elizabeth, Lillycrop, Karen, Han, Lihua, Napier, Johnathan, Calder, Philip and Burdge, Graham (2020) Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte docosahexaenoic acid and eicosapentaenoic acid to fish oil in healthy humans. British Journal of Nutrition, 1-9. (doi:10.1017/S0007114520002044).

Record type: Article

Abstract

EPA and DHA are required for normal cell function and can also induce health benefits. Oily fish are the main source of EPA and DHA for human consumption. However, food choices and concerns about the sustainability of marine fish stocks limit the effectiveness of dietary recommendations for EPA+DHA intakes. Seed oils from transgenic plants that contain EPA+DHA are a potential alternative source of EPA and DHA. To test this, the present study investigated whether dietary supplementation with transgenic Camelina sativa seed oil (CSO) that contained EPA and DHA was as effective as fish oil (FO) in increasing EPA and DHA concentrations when consumed as a dietary supplement in a blinded crossover study. Healthy men and women (n 31; age 53 (20-74) yrs) were randomised to consume 450 mg/day EPA+DHA provided either as either CSO or FO for 8 weeks, followed by 6 weeks washout and then switched to consuming the other test oil. Fasting venous blood samples were collected at the start and end of each supplementation period. Consuming the test oils significantly (P < 0.05) increased EPA and DHA concentrations in plasma triacylglycerol, phosphatidylcholine and cholesteryl esters. There were no significant differences between test oils in the increments of EPA and DHA. There was no significant difference between test oils in the increase in the proportion of erythrocyte EPA+DHA (CSO, 12%; P < 0.0001and FO, 8%; P = 0.02). Together these findings show that consuming CSO is as effective as FO for increasing EPA and DHA concentrations in humans.

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Paper 3 Accepted version 02 June 2020 - Accepted Manuscript
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dietary supplementation with seed oil from transgenic camelina sativa induces similar increments in plasma and erythrocyte dha and epa to fish oil in healthy humans - Version of Record
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Accepted/In Press date: 2 June 2020
e-pub ahead of print date: 9 June 2020
Keywords: Camelia sativa, Dietary Supplementation, Human Diet, Omega 3, Transgenic plant

Identifiers

Local EPrints ID: 441259
URI: http://eprints.soton.ac.uk/id/eprint/441259
ISSN: 0007-1145
PURE UUID: 4267d377-1ac5-464e-bdb4-dca4cec7517a
ORCID for Annette West: ORCID iD orcid.org/0000-0002-3331-0684
ORCID for Elizabeth Miles: ORCID iD orcid.org/0000-0002-8643-0655
ORCID for Karen Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X
ORCID for Graham Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 08 Jun 2020 16:30
Last modified: 26 Nov 2021 02:49

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Contributors

Author: Annette West ORCID iD
Author: Elizabeth Miles ORCID iD
Author: Karen Lillycrop ORCID iD
Author: Lihua Han
Author: Johnathan Napier
Author: Philip Calder ORCID iD
Author: Graham Burdge ORCID iD

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