Printed electroceutical dressings for the inhibition of biofilms and treatment of chronic wounds
Printed electroceutical dressings for the inhibition of biofilms and treatment of chronic wounds
We report on an innovative, fabric-based conformable, and easily fabricated electroceutical wound dressing that inhibits bacterial biofilm infections and shows significant promise for healing chronic wounds. Cyclic voltammetry demonstrates the ability of the electroceutical to produce reactive oxygen species, primarily HOCl that is responsible for bacterial inhibition. In vitro investigation with the lawn biofilm grown on a soft tissue mimic assay shows the efficacy of the dressing against both gram-positive and gram-negative bacteria in the biofilm form. In vivo, the printed electroceutical dressing was utilized as an intervention treatment for a canine subject with a non-healing wound due to a year-long persistent polymicrobial infection. The clinical case study with the canine subject exhibited the applicability in a clinical setting with the results showing infection inhibition within 11 days of initial treatment. This printed electroceutical dressing was integrated with a Bluetooth® enabled circuit allowing remote monitoring of the current flow within the wound bed. The potential to monitor wounds remotely in real-time with a Bluetooth® enabled circuit proposes a new physical biomarker for management of infected, chronic wounds.
Electroceuticals, Dressing, Wound, Chronic, Biofilm, Treatment
918-923
Heald, Rachel
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Bennett, Molly
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Subramaniam, Vish V.
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Dusane, Devendra
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Lochab, Varun
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Mohana Sunaram, Prashanth
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Salyer, Sarah
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West, J.D.
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Stoodley, Paul
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Prakash, Shaurya
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Heald, Rachel
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Bennett, Molly
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Subramaniam, Vish V.
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Dusane, Devendra
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Lochab, Varun
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Mohana Sunaram, Prashanth
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Salyer, Sarah
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West, J.D.
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Stoodley, Paul
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Prakash, Shaurya
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Heald, Rachel, Bennett, Molly, Subramaniam, Vish V., Dusane, Devendra, Lochab, Varun, Mohana Sunaram, Prashanth, Salyer, Sarah, West, J.D., Stoodley, Paul and Prakash, Shaurya
(2020)
Printed electroceutical dressings for the inhibition of biofilms and treatment of chronic wounds.
IEEE Journal of Microelectromechanical Systems, 29 (5), .
(doi:10.1109/jmems.2020.2999260).
Abstract
We report on an innovative, fabric-based conformable, and easily fabricated electroceutical wound dressing that inhibits bacterial biofilm infections and shows significant promise for healing chronic wounds. Cyclic voltammetry demonstrates the ability of the electroceutical to produce reactive oxygen species, primarily HOCl that is responsible for bacterial inhibition. In vitro investigation with the lawn biofilm grown on a soft tissue mimic assay shows the efficacy of the dressing against both gram-positive and gram-negative bacteria in the biofilm form. In vivo, the printed electroceutical dressing was utilized as an intervention treatment for a canine subject with a non-healing wound due to a year-long persistent polymicrobial infection. The clinical case study with the canine subject exhibited the applicability in a clinical setting with the results showing infection inhibition within 11 days of initial treatment. This printed electroceutical dressing was integrated with a Bluetooth® enabled circuit allowing remote monitoring of the current flow within the wound bed. The potential to monitor wounds remotely in real-time with a Bluetooth® enabled circuit proposes a new physical biomarker for management of infected, chronic wounds.
Text
JMEMS_HHManuscript_PED_vFinal
More information
Accepted/In Press date: 28 May 2020
e-pub ahead of print date: 10 June 2020
Keywords:
Electroceuticals, Dressing, Wound, Chronic, Biofilm, Treatment
Identifiers
Local EPrints ID: 441271
URI: http://eprints.soton.ac.uk/id/eprint/441271
PURE UUID: c7d9c59d-5a30-424b-9ce1-afe0bb379929
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Date deposited: 08 Jun 2020 16:31
Last modified: 17 Mar 2024 05:37
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Contributors
Author:
Rachel Heald
Author:
Molly Bennett
Author:
Vish V. Subramaniam
Author:
Devendra Dusane
Author:
Varun Lochab
Author:
Prashanth Mohana Sunaram
Author:
Sarah Salyer
Author:
J.D. West
Author:
Shaurya Prakash
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