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Printed electroceutical dressings for the inhibition of biofilms and treatment of chronic wounds

Printed electroceutical dressings for the inhibition of biofilms and treatment of chronic wounds
Printed electroceutical dressings for the inhibition of biofilms and treatment of chronic wounds
We report on an innovative, fabric-based conformable, and easily fabricated electroceutical wound dressing that inhibits bacterial biofilm infections and shows significant promise for healing chronic wounds. Cyclic voltammetry demonstrates the ability of the electroceutical to produce reactive oxygen species, primarily HOCl that is responsible for bacterial inhibition. In vitro investigation with the lawn biofilm grown on a soft tissue mimic assay shows the efficacy of the dressing against both gram-positive and gram-negative bacteria in the biofilm form. In vivo, the printed electroceutical dressing was utilized as an intervention treatment for a canine subject with a non-healing wound due to a year-long persistent polymicrobial infection. The clinical case study with the canine subject exhibited the applicability in a clinical setting with the results showing infection inhibition within 11 days of initial treatment. This printed electroceutical dressing was integrated with a Bluetooth® enabled circuit allowing remote monitoring of the current flow within the wound bed. The potential to monitor wounds remotely in real-time with a Bluetooth® enabled circuit proposes a new physical biomarker for management of infected, chronic wounds.
Electroceuticals, Dressing, Wound, Chronic, Biofilm, Treatment
Heald, Rachel
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Bennett, Molly
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Subramaniam, Vish V.
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Dusane, Devendra
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Lochab, Varun
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Mohana Sunaram, Prashanth
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Salyer, Sarah
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West, J.D.
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Stoodley, Paul
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Prakash, Shaurya
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Heald, Rachel
9a8cf026-9bcb-428e-8170-d958db3a9df4
Bennett, Molly
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Subramaniam, Vish V.
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Dusane, Devendra
6c396d1d-c25a-481a-9beb-cad5c76eb090
Lochab, Varun
64ab1066-34f4-4bea-b8e9-089d0014c02c
Mohana Sunaram, Prashanth
4484ab19-50f6-46d4-bf77-c7c5e497aba5
Salyer, Sarah
cddcb255-2372-4675-b7be-9cda9d990190
West, J.D.
a5a63c8a-f843-4f6b-ad59-c49a39bec01f
Stoodley, Paul
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Prakash, Shaurya
54775442-9f96-4129-b93d-082a5ff91d9b

Heald, Rachel, Bennett, Molly, Subramaniam, Vish V., Dusane, Devendra, Lochab, Varun, Mohana Sunaram, Prashanth, Salyer, Sarah, West, J.D., Stoodley, Paul and Prakash, Shaurya (2020) Printed electroceutical dressings for the inhibition of biofilms and treatment of chronic wounds. IEEE Journal of Microelectromechanical Systems. (In Press)

Record type: Article

Abstract

We report on an innovative, fabric-based conformable, and easily fabricated electroceutical wound dressing that inhibits bacterial biofilm infections and shows significant promise for healing chronic wounds. Cyclic voltammetry demonstrates the ability of the electroceutical to produce reactive oxygen species, primarily HOCl that is responsible for bacterial inhibition. In vitro investigation with the lawn biofilm grown on a soft tissue mimic assay shows the efficacy of the dressing against both gram-positive and gram-negative bacteria in the biofilm form. In vivo, the printed electroceutical dressing was utilized as an intervention treatment for a canine subject with a non-healing wound due to a year-long persistent polymicrobial infection. The clinical case study with the canine subject exhibited the applicability in a clinical setting with the results showing infection inhibition within 11 days of initial treatment. This printed electroceutical dressing was integrated with a Bluetooth® enabled circuit allowing remote monitoring of the current flow within the wound bed. The potential to monitor wounds remotely in real-time with a Bluetooth® enabled circuit proposes a new physical biomarker for management of infected, chronic wounds.

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More information

Accepted/In Press date: 28 May 2020
Keywords: Electroceuticals, Dressing, Wound, Chronic, Biofilm, Treatment

Identifiers

Local EPrints ID: 441271
URI: http://eprints.soton.ac.uk/id/eprint/441271
PURE UUID: c7d9c59d-5a30-424b-9ce1-afe0bb379929
ORCID for Paul Stoodley: ORCID iD orcid.org/0000-0001-6069-273X

Catalogue record

Date deposited: 08 Jun 2020 16:31
Last modified: 13 Dec 2021 06:03

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Contributors

Author: Rachel Heald
Author: Molly Bennett
Author: Vish V. Subramaniam
Author: Devendra Dusane
Author: Varun Lochab
Author: Prashanth Mohana Sunaram
Author: Sarah Salyer
Author: J.D. West
Author: Paul Stoodley ORCID iD
Author: Shaurya Prakash

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