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EAACI Allergen Immunotherapy User's Guide

EAACI Allergen Immunotherapy User's Guide
EAACI Allergen Immunotherapy User's Guide

Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical efficiency relies on a well-defined immunologic mechanism promoting regulatory T cells and downplaying the immune response induced by allergens. Clinical indications have been well documented for respiratory allergy in the presence of rhinitis and/or allergic asthma, to pollens and dust mites. Patients who have had an anaphylactic reaction to hymenoptera venom are also good candidates for allergen immunotherapy. Administration of allergen is currently mostly either by subcutaneous injections or by sublingual administration. Both methods have been extensively studied and have pros and cons. Specifically in children, the choice of the method of administration according to the patient's profile is important. Although allergen immunotherapy is widely used, there is a need for improvement. More particularly, biomarkers for prediction of the success of the treatments are needed. The strength and efficiency of the immune response may also be boosted by the use of better adjuvants. Finally, novel formulations might be more efficient and might improve the patient's adherence to the treatment. This user's guide reviews current knowledge and aims to provide clinical guidance to healthcare professionals taking care of children undergoing allergen immunotherapy.

Allergy, immune regulation, immunotherapy, tolerance
0905-6157
1-101
Alvaro-Lozano, Montserrat
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Akdis, Cezmi A
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Akdis, Mubeccel
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Alviani, Cherry
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Angier, Elisabeth
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Arasi, Stefania
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Arzt-Gradwohl, Lisa
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Barber, Domingo
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Bazire, Raphaëlle
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Cavkaytar, Ozlem
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Comberiati, Pasquale
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Dramburg, Stephanie
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Durham, Stephen R
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Eifan, Aarif O
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Forchert, Leandra
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Halken, Susanne
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Kirtland, Max
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Kucuksezer, Umut C
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Layhadi, Janice A
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Matricardi, Paolo Maria
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Muraro, Antonella
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Ozdemir, Cevdet
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Pajno, Giovanni Battista
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Pfaar, Oliver
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Potapova, Ekaterina
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Riggioni, Carmen
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Roberts, Graham
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Rodríguez Del Río, Pablo
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Shamji, Mohamed H
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Sturm, Gunter J
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Vazquez-Ortiz, Marta
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Alvaro-Lozano, Montserrat
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Akdis, Cezmi A
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Akdis, Mubeccel
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Alviani, Cherry
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Angier, Elisabeth
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Arasi, Stefania
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Arzt-Gradwohl, Lisa
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Barber, Domingo
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Bazire, Raphaëlle
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Cavkaytar, Ozlem
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Comberiati, Pasquale
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Dramburg, Stephanie
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Durham, Stephen R
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Eifan, Aarif O
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Forchert, Leandra
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Halken, Susanne
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Kirtland, Max
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Kucuksezer, Umut C
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Layhadi, Janice A
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Matricardi, Paolo Maria
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Muraro, Antonella
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Ozdemir, Cevdet
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Pajno, Giovanni Battista
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Pfaar, Oliver
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Potapova, Ekaterina
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Riggioni, Carmen
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Roberts, Graham
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Rodríguez Del Río, Pablo
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Shamji, Mohamed H
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Sturm, Gunter J
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Vazquez-Ortiz, Marta
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Alvaro-Lozano, Montserrat, Akdis, Cezmi A, Akdis, Mubeccel, Alviani, Cherry, Angier, Elisabeth, Arasi, Stefania, Arzt-Gradwohl, Lisa, Barber, Domingo, Bazire, Raphaëlle, Cavkaytar, Ozlem, Comberiati, Pasquale, Dramburg, Stephanie, Durham, Stephen R, Eifan, Aarif O, Forchert, Leandra, Halken, Susanne, Kirtland, Max, Kucuksezer, Umut C, Layhadi, Janice A, Matricardi, Paolo Maria, Muraro, Antonella, Ozdemir, Cevdet, Pajno, Giovanni Battista, Pfaar, Oliver, Potapova, Ekaterina, Riggioni, Carmen, Roberts, Graham, Rodríguez Del Río, Pablo, Shamji, Mohamed H, Sturm, Gunter J and Vazquez-Ortiz, Marta (2020) EAACI Allergen Immunotherapy User's Guide. Pediatric Allergy and Immunology, 31 (S25), 1-101. (doi:10.1111/pai.13189).

Record type: Article

Abstract

Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical efficiency relies on a well-defined immunologic mechanism promoting regulatory T cells and downplaying the immune response induced by allergens. Clinical indications have been well documented for respiratory allergy in the presence of rhinitis and/or allergic asthma, to pollens and dust mites. Patients who have had an anaphylactic reaction to hymenoptera venom are also good candidates for allergen immunotherapy. Administration of allergen is currently mostly either by subcutaneous injections or by sublingual administration. Both methods have been extensively studied and have pros and cons. Specifically in children, the choice of the method of administration according to the patient's profile is important. Although allergen immunotherapy is widely used, there is a need for improvement. More particularly, biomarkers for prediction of the success of the treatments are needed. The strength and efficiency of the immune response may also be boosted by the use of better adjuvants. Finally, novel formulations might be more efficient and might improve the patient's adherence to the treatment. This user's guide reviews current knowledge and aims to provide clinical guidance to healthcare professionals taking care of children undergoing allergen immunotherapy.

Text
pai.13189 - Version of Record
Available under License Creative Commons Attribution Non-commercial.
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More information

e-pub ahead of print date: 21 May 2020
Published date: May 2020
Keywords: Allergy, immune regulation, immunotherapy, tolerance

Identifiers

Local EPrints ID: 441313
URI: http://eprints.soton.ac.uk/id/eprint/441313
DOI: doi:10.1111/pai.13189
ISSN: 0905-6157
PURE UUID: 8e3aed2f-3402-4842-8658-34e695ce8f3a
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 09 Jun 2020 16:30
Last modified: 17 Mar 2024 03:01

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Contributors

Author: Montserrat Alvaro-Lozano
Author: Cezmi A Akdis
Author: Mubeccel Akdis
Author: Cherry Alviani
Author: Elisabeth Angier
Author: Stefania Arasi
Author: Lisa Arzt-Gradwohl
Author: Domingo Barber
Author: Raphaëlle Bazire
Author: Ozlem Cavkaytar
Author: Pasquale Comberiati
Author: Stephanie Dramburg
Author: Stephen R Durham
Author: Aarif O Eifan
Author: Leandra Forchert
Author: Susanne Halken
Author: Max Kirtland
Author: Umut C Kucuksezer
Author: Janice A Layhadi
Author: Paolo Maria Matricardi
Author: Antonella Muraro
Author: Cevdet Ozdemir
Author: Giovanni Battista Pajno
Author: Oliver Pfaar
Author: Ekaterina Potapova
Author: Carmen Riggioni
Author: Graham Roberts ORCID iD
Author: Pablo Rodríguez Del Río
Author: Mohamed H Shamji
Author: Gunter J Sturm
Author: Marta Vazquez-Ortiz

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