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The relationship between the dietary inflammatory index and risk of total cardiovascular disease, ischemic heart disease and cerebrovascular disease: Findings from an Australian population-based prospective cohort study of women

The relationship between the dietary inflammatory index and risk of total cardiovascular disease, ischemic heart disease and cerebrovascular disease: Findings from an Australian population-based prospective cohort study of women
The relationship between the dietary inflammatory index and risk of total cardiovascular disease, ischemic heart disease and cerebrovascular disease: Findings from an Australian population-based prospective cohort study of women

BACKGROUND AND AIMS: Recently, a pro-inflammatory diet based on a dietary inflammatory index (DII) has been related to higher CVD risk in general population, but this has not been investigated among women.

METHODS: We investigated the relationship between DII and risk of total CVD and CVD subgroups (myocardial infarction, ischemic heart disease, stroke and cerebrovascular disease) in a prospective cohort of 6972 Australian women aged 50-55 years at baseline in 2001. We used clinical and procedure information from inpatient hospital separation registries, information on use of health care services, and from the causes-of-death registry to ascertain CVD outcomes during 11-year follow up. The association between baseline DII score and cardiovascular endpoints was analysed through cox-regression, with correction for demographic and cardiovascular risk factors.

RESULTS: We identified 335 incident cases of CVD and 191 cases of ischaemic heart disease (including 69 myocardial infarctions) and 59 cases of cerebrovascular disease (including 40 cases of stroke). A statistically significant higher risk of myocardial infarction was observed in analyses using DII scores as a continuous variable with a hazard ratio of 1.46 (95% confidence interval 1.12-1.89), but this was attenuated by further adjustment for other known cardiovascular risk factors. No association was found for total CVD, ischaemic heart diseases, or cerebrovascular disease.

CONCLUSIONS: There was no statistically significant association between the dietary inflammatory index and risk of total cardiovascular disease, ischemic heart disease, myocardial infarction, cerebrovascular disease or stroke in this population of mid-aged Australian women. Associations were not different for postmenopausal women.

Age Factors, Australia, Cardiovascular Diseases/complications, Cerebrovascular Disorders/complications, Coronary Artery Disease, Diet, Female, Follow-Up Studies, Humans, Inflammation/complications, Inpatients, Longitudinal Studies, Middle Aged, Myocardial Infarction/epidemiology, Myocardial Ischemia/complications, Proportional Hazards Models, Prospective Studies, Registries, Risk Factors, Stroke/epidemiology, Treatment Outcome
0021-9150
164-170
Vissers, Linda E.T.
cd46d7d6-3abe-4da2-8cbc-a577c3b3e8e0
Waller, Michael A.
21409d44-718f-45dc-9168-a0f1b3db4421
van der Schouw, Yvonne T.
3ca96f0b-f3e3-401d-bdf1-7f4463f5c040
Hebert, James R.
486a9a8e-77ff-4dec-a74d-bbf8d1d55728
Shivappa, Nitin
1c0b527d-0366-4fb6-9e7d-1342b2009e8f
Schoenaker, Danielle A.J.M.
84b96b87-4070-45a5-9777-5a1e4e45e818
Mishra, Gita D.
02143b82-e536-4915-9b30-3c86cbe1a1fe
Vissers, Linda E.T.
cd46d7d6-3abe-4da2-8cbc-a577c3b3e8e0
Waller, Michael A.
21409d44-718f-45dc-9168-a0f1b3db4421
van der Schouw, Yvonne T.
3ca96f0b-f3e3-401d-bdf1-7f4463f5c040
Hebert, James R.
486a9a8e-77ff-4dec-a74d-bbf8d1d55728
Shivappa, Nitin
1c0b527d-0366-4fb6-9e7d-1342b2009e8f
Schoenaker, Danielle A.J.M.
84b96b87-4070-45a5-9777-5a1e4e45e818
Mishra, Gita D.
02143b82-e536-4915-9b30-3c86cbe1a1fe

Vissers, Linda E.T., Waller, Michael A., van der Schouw, Yvonne T., Hebert, James R., Shivappa, Nitin, Schoenaker, Danielle A.J.M. and Mishra, Gita D. (2016) The relationship between the dietary inflammatory index and risk of total cardiovascular disease, ischemic heart disease and cerebrovascular disease: Findings from an Australian population-based prospective cohort study of women. Atherosclerosis, 253, 164-170. (doi:10.1016/j.atherosclerosis.2016.07.929).

Record type: Article

Abstract

BACKGROUND AND AIMS: Recently, a pro-inflammatory diet based on a dietary inflammatory index (DII) has been related to higher CVD risk in general population, but this has not been investigated among women.

METHODS: We investigated the relationship between DII and risk of total CVD and CVD subgroups (myocardial infarction, ischemic heart disease, stroke and cerebrovascular disease) in a prospective cohort of 6972 Australian women aged 50-55 years at baseline in 2001. We used clinical and procedure information from inpatient hospital separation registries, information on use of health care services, and from the causes-of-death registry to ascertain CVD outcomes during 11-year follow up. The association between baseline DII score and cardiovascular endpoints was analysed through cox-regression, with correction for demographic and cardiovascular risk factors.

RESULTS: We identified 335 incident cases of CVD and 191 cases of ischaemic heart disease (including 69 myocardial infarctions) and 59 cases of cerebrovascular disease (including 40 cases of stroke). A statistically significant higher risk of myocardial infarction was observed in analyses using DII scores as a continuous variable with a hazard ratio of 1.46 (95% confidence interval 1.12-1.89), but this was attenuated by further adjustment for other known cardiovascular risk factors. No association was found for total CVD, ischaemic heart diseases, or cerebrovascular disease.

CONCLUSIONS: There was no statistically significant association between the dietary inflammatory index and risk of total cardiovascular disease, ischemic heart disease, myocardial infarction, cerebrovascular disease or stroke in this population of mid-aged Australian women. Associations were not different for postmenopausal women.

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More information

Accepted/In Press date: 27 July 2016
e-pub ahead of print date: 30 July 2016
Published date: October 2016
Keywords: Age Factors, Australia, Cardiovascular Diseases/complications, Cerebrovascular Disorders/complications, Coronary Artery Disease, Diet, Female, Follow-Up Studies, Humans, Inflammation/complications, Inpatients, Longitudinal Studies, Middle Aged, Myocardial Infarction/epidemiology, Myocardial Ischemia/complications, Proportional Hazards Models, Prospective Studies, Registries, Risk Factors, Stroke/epidemiology, Treatment Outcome

Identifiers

Local EPrints ID: 441326
URI: http://eprints.soton.ac.uk/id/eprint/441326
ISSN: 0021-9150
PURE UUID: 0663f05e-b9e7-4f5e-8b33-84a4a8280d51
ORCID for Danielle A.J.M. Schoenaker: ORCID iD orcid.org/0000-0002-7652-990X

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Date deposited: 09 Jun 2020 16:31
Last modified: 11 Aug 2022 02:01

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Contributors

Author: Linda E.T. Vissers
Author: Michael A. Waller
Author: Yvonne T. van der Schouw
Author: James R. Hebert
Author: Nitin Shivappa
Author: Gita D. Mishra

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