Animal models of ocular tuberculosis: implications for diagnosis and treatment
Animal models of ocular tuberculosis: implications for diagnosis and treatment
The pathogenesis of ocular tuberculosis (TB) has remained unclear due to the challenges of performing mechanistic studies on clinical samples. Animal models have the potential to bridge these gaps by providing information about ocular dissemination and localization of mycobacteria, innate and adaptive immune response, and granuloma formation in the eye. Here, we critically review various animal models of ocular TB from the early 20th century to date and derive novel insights into pathogenesis of ocular TB that have direct implications on the diagnosis and treatment of this disease. Future directions on experimental approaches to understanding pathogenesis of ocular TB are also discussed.
Tuberculosis, animal model, ocular, pathogenesis, uveitis
1-7
Basu, Soumyava
66d3ccb1-201d-417b-b929-7d331ede06cf
Rao, Narsing
c86e45a4-9d4f-4181-8476-b4f2571423a5
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Basu, Soumyava
66d3ccb1-201d-417b-b929-7d331ede06cf
Rao, Narsing
c86e45a4-9d4f-4181-8476-b4f2571423a5
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Basu, Soumyava, Rao, Narsing and Elkington, Paul
(2020)
Animal models of ocular tuberculosis: implications for diagnosis and treatment.
Ocular Immunology and Inflammation, .
(doi:10.1080/09273948.2020.1746358).
Abstract
The pathogenesis of ocular tuberculosis (TB) has remained unclear due to the challenges of performing mechanistic studies on clinical samples. Animal models have the potential to bridge these gaps by providing information about ocular dissemination and localization of mycobacteria, innate and adaptive immune response, and granuloma formation in the eye. Here, we critically review various animal models of ocular TB from the early 20th century to date and derive novel insights into pathogenesis of ocular TB that have direct implications on the diagnosis and treatment of this disease. Future directions on experimental approaches to understanding pathogenesis of ocular TB are also discussed.
Text
Animal models_final
- Accepted Manuscript
More information
Accepted/In Press date: 19 March 2020
e-pub ahead of print date: 14 May 2020
Keywords:
Tuberculosis, animal model, ocular, pathogenesis, uveitis
Identifiers
Local EPrints ID: 441416
URI: http://eprints.soton.ac.uk/id/eprint/441416
ISSN: 0927-3948
PURE UUID: 9ba6d491-ac93-45e0-a4b8-240b65c2ce45
Catalogue record
Date deposited: 11 Jun 2020 16:40
Last modified: 17 Mar 2024 05:38
Export record
Altmetrics
Contributors
Author:
Soumyava Basu
Author:
Narsing Rao
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
