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Animal models of ocular tuberculosis: implications for diagnosis and treatment

Animal models of ocular tuberculosis: implications for diagnosis and treatment
Animal models of ocular tuberculosis: implications for diagnosis and treatment
The pathogenesis of ocular tuberculosis (TB) has remained unclear due to the challenges of performing mechanistic studies on clinical samples. Animal models have the potential to bridge these gaps by providing information about ocular dissemination and localization of mycobacteria, innate and adaptive immune response, and granuloma formation in the eye. Here, we critically review various animal models of ocular TB from the early 20th century to date and derive novel insights into pathogenesis of ocular TB that have direct implications on the diagnosis and treatment of this disease. Future directions on experimental approaches to understanding pathogenesis of ocular TB are also discussed.
Tuberculosis, animal model, ocular, pathogenesis, uveitis
0927-3948
1-7
Basu, Soumyava
66d3ccb1-201d-417b-b929-7d331ede06cf
Rao, Narsing
c86e45a4-9d4f-4181-8476-b4f2571423a5
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Basu, Soumyava
66d3ccb1-201d-417b-b929-7d331ede06cf
Rao, Narsing
c86e45a4-9d4f-4181-8476-b4f2571423a5
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15

Basu, Soumyava, Rao, Narsing and Elkington, Paul (2020) Animal models of ocular tuberculosis: implications for diagnosis and treatment. Ocular Immunology and Inflammation, 1-7. (doi:10.1080/09273948.2020.1746358).

Record type: Review

Abstract

The pathogenesis of ocular tuberculosis (TB) has remained unclear due to the challenges of performing mechanistic studies on clinical samples. Animal models have the potential to bridge these gaps by providing information about ocular dissemination and localization of mycobacteria, innate and adaptive immune response, and granuloma formation in the eye. Here, we critically review various animal models of ocular TB from the early 20th century to date and derive novel insights into pathogenesis of ocular TB that have direct implications on the diagnosis and treatment of this disease. Future directions on experimental approaches to understanding pathogenesis of ocular TB are also discussed.

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Animal models_final - Accepted Manuscript
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Accepted/In Press date: 19 March 2020
e-pub ahead of print date: 14 May 2020
Keywords: Tuberculosis, animal model, ocular, pathogenesis, uveitis

Identifiers

Local EPrints ID: 441416
URI: http://eprints.soton.ac.uk/id/eprint/441416
ISSN: 0927-3948
PURE UUID: 9ba6d491-ac93-45e0-a4b8-240b65c2ce45
ORCID for Paul Elkington: ORCID iD orcid.org/0000-0003-0390-0613

Catalogue record

Date deposited: 11 Jun 2020 16:40
Last modified: 26 Nov 2021 06:34

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Contributors

Author: Soumyava Basu
Author: Narsing Rao
Author: Paul Elkington ORCID iD

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