The effect of ventilation tube insertion on quality of life in children with persistent otitis media with effusion
The effect of ventilation tube insertion on quality of life in children with persistent otitis media with effusion
Objectives: To determine the effect of ventilation tube (VT) surgery on quality of life (QoL) in children with persistent otitis media with effusion (OME). Design: Secondary analysis of trial data (oral steroids versus placebo for persistent OME), comparing QoL by history of VT surgery performed between 5 weeks and 12 months post-randomisation. Multilevel regression models were used to identify the association between VT surgery and QoL scores at 12 months, controlling for pre-exposure risk factors associated with surgery, including pre-surgery hearing level. Setting: Ear, nose and throat (ENT), paediatric audiology and audiovestibular medicine (AVM) departments in Wales and England. Participants: A total of 327 children aged 2-8 years with OME symptoms for at least three months and audiometry-proven bilateral hearing loss with VT surgery status. Main outcome measures: Otitis Media questionnaire (OM8-30) and Paediatric Quality of Life Inventory (PedsQL) total and subscale scores, and the Health Utilities Index Mark 3 (HUI3) at 12 months post-randomisation. Results: Participants who had VT surgery had no significant difference in OM8-30, PedsQL or HUI total scores. OM8-30 hearing difficulty (HD) subscale scores at 12 months were better in those who had VT surgery (adjusted mean difference (aMD) = −0.46 (95% confidence interval: −0.69 to −0.23), P <.001), and this varied by when the surgery occurred (aMD for surgery between 5 weeks and 6 months = −0.4 [−0.67 to −0.13], P =.004 and between 6 and 12 months = −0.54, [−0.87 to −0.22], P =.001). Conclusion: Ventilation tube surgery was associated with an improvement in HD-related functional health status but no change in overall QoL.
audiology, otitis media, otitis media with effusion, otolaryngology, otologic surgical procedures, quality of life
239-247
Sanyaolu, Leigh N.
2771f299-40e7-40c3-809d-da9c87134328
Cannings-John, Rebecca
f45c9562-b1d0-4c6d-9c7c-8f27cd3e47cd
Butler, Christopher C.
8bf4cace-c34a-4b65-838f-29c2be91e434
Francis, Nick A.
9b610883-605c-4fee-871d-defaa86ccf8e
1 March 2020
Sanyaolu, Leigh N.
2771f299-40e7-40c3-809d-da9c87134328
Cannings-John, Rebecca
f45c9562-b1d0-4c6d-9c7c-8f27cd3e47cd
Butler, Christopher C.
8bf4cace-c34a-4b65-838f-29c2be91e434
Francis, Nick A.
9b610883-605c-4fee-871d-defaa86ccf8e
Sanyaolu, Leigh N., Cannings-John, Rebecca, Butler, Christopher C. and Francis, Nick A.
(2020)
The effect of ventilation tube insertion on quality of life in children with persistent otitis media with effusion.
Clinical Otolaryngology, 45 (2), .
(doi:10.1111/coa.13502).
Abstract
Objectives: To determine the effect of ventilation tube (VT) surgery on quality of life (QoL) in children with persistent otitis media with effusion (OME). Design: Secondary analysis of trial data (oral steroids versus placebo for persistent OME), comparing QoL by history of VT surgery performed between 5 weeks and 12 months post-randomisation. Multilevel regression models were used to identify the association between VT surgery and QoL scores at 12 months, controlling for pre-exposure risk factors associated with surgery, including pre-surgery hearing level. Setting: Ear, nose and throat (ENT), paediatric audiology and audiovestibular medicine (AVM) departments in Wales and England. Participants: A total of 327 children aged 2-8 years with OME symptoms for at least three months and audiometry-proven bilateral hearing loss with VT surgery status. Main outcome measures: Otitis Media questionnaire (OM8-30) and Paediatric Quality of Life Inventory (PedsQL) total and subscale scores, and the Health Utilities Index Mark 3 (HUI3) at 12 months post-randomisation. Results: Participants who had VT surgery had no significant difference in OM8-30, PedsQL or HUI total scores. OM8-30 hearing difficulty (HD) subscale scores at 12 months were better in those who had VT surgery (adjusted mean difference (aMD) = −0.46 (95% confidence interval: −0.69 to −0.23), P <.001), and this varied by when the surgery occurred (aMD for surgery between 5 weeks and 6 months = −0.4 [−0.67 to −0.13], P =.004 and between 6 and 12 months = −0.54, [−0.87 to −0.22], P =.001). Conclusion: Ventilation tube surgery was associated with an improvement in HD-related functional health status but no change in overall QoL.
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More information
Accepted/In Press date: 12 December 2019
e-pub ahead of print date: 23 December 2019
Published date: 1 March 2020
Additional Information:
Funding Information:
We would like to thank the participants of the OSTRICH study and their parents, and we would like to acknowledge all the clinicians and research team who contributed to the OSTRICH trial and made this analysis possible.
Publisher Copyright:
© 2019 John Wiley & Sons Ltd
Keywords:
audiology, otitis media, otitis media with effusion, otolaryngology, otologic surgical procedures, quality of life
Identifiers
Local EPrints ID: 441453
URI: http://eprints.soton.ac.uk/id/eprint/441453
ISSN: 1749-4478
PURE UUID: 673c1412-ac90-4294-b485-208a043d7ab5
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Date deposited: 12 Jun 2020 16:40
Last modified: 17 Mar 2024 03:58
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Contributors
Author:
Leigh N. Sanyaolu
Author:
Rebecca Cannings-John
Author:
Christopher C. Butler
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