2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix-assisted laser desorption/ionisation
2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix-assisted laser desorption/ionisation
The effective use of pencil as a matrix for matrix-assisted laser desorption/ionisation (MALDI) for the study of actinides has previously been demonstrated (Black et al., Rapid Commun. Mass Spectrom. 2006; 20: 1053). Here, the scope of the types of molecules amenable to analysis by this method has been extended, establishing that 90% of a library containing 50 diverse small molecules can be successfully analysed by this technique. Further, the role played by the bulk materials present in the different pencil leads has been investigated and a simple one-step deposition of matrix and calibration materials has been achieved through the fabrication of different calibration pencils (Cali-Pens)
Mass spectrometry, MALDI matrix, pencil matrix, MALDI
180-190
Langley, G.J.
7ac80d61-b91d-4261-ad17-255f94ea21ea
Herniman, J.M.
530b1a36-1386-4602-8df7-defa6eb3512b
Townell, M.S.
5ba6fcf7-b56c-47ac-8eb1-a107cc136813
January 2007
Langley, G.J.
7ac80d61-b91d-4261-ad17-255f94ea21ea
Herniman, J.M.
530b1a36-1386-4602-8df7-defa6eb3512b
Townell, M.S.
5ba6fcf7-b56c-47ac-8eb1-a107cc136813
Langley, G.J., Herniman, J.M. and Townell, M.S.
(2007)
2B or not 2B, that is the question: further investigations into the use of pencil as a matrix for matrix-assisted laser desorption/ionisation.
Rapid Communications in Mass Spectrometry, 21 (2), .
(doi:10.1002/rcm.2827).
Abstract
The effective use of pencil as a matrix for matrix-assisted laser desorption/ionisation (MALDI) for the study of actinides has previously been demonstrated (Black et al., Rapid Commun. Mass Spectrom. 2006; 20: 1053). Here, the scope of the types of molecules amenable to analysis by this method has been extended, establishing that 90% of a library containing 50 diverse small molecules can be successfully analysed by this technique. Further, the role played by the bulk materials present in the different pencil leads has been investigated and a simple one-step deposition of matrix and calibration materials has been achieved through the fabrication of different calibration pencils (Cali-Pens)
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2B_or_not_2B,_that_is_the_question.pdf
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Submitted date: 20 September 2006
Published date: January 2007
Keywords:
Mass spectrometry, MALDI matrix, pencil matrix, MALDI
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Local EPrints ID: 44150
URI: http://eprints.soton.ac.uk/id/eprint/44150
ISSN: 0951-4198
PURE UUID: 49642c28-1c00-4e41-80ee-021acdb451c8
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Date deposited: 16 Feb 2007
Last modified: 16 Mar 2024 03:02
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Author:
M.S. Townell
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