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Developmental origins of health and disease: impact of environmental dust exposure in modulating microbiome and its association with non-communicable diseases

Developmental origins of health and disease: impact of environmental dust exposure in modulating microbiome and its association with non-communicable diseases
Developmental origins of health and disease: impact of environmental dust exposure in modulating microbiome and its association with non-communicable diseases
Non-communicable diseases (NCDs) including obesity, diabetes and allergy are chronic, multi-factorial conditions that are affected by both genetic and environmental factors. Over the last decade, the microbiome has emerged as a possible contributor to the pathogenesis of NCDs. Microbiome profiles were altered in patients with NCDs, and shift in microbial communities was associated with improvement in these health conditions. Since the genetic component of these diseases cannot be altered, the ability to manipulate the microbiome holds great promise for design of novel therapies in the prevention and treatment of NCDs. Together, the Developmental Origins of Health and Disease (DOHaD) concept and the microbial hypothesis propose that early life exposure to environmental stimuli will alter the development and composition of the human microbiome, resulting in health consequences. Recent studies indicated that the environment we are exposed to in early life is instrumental in shaping robust immune development, possibly through modulation of the human microbiome (skin, airway and gut). Despite much research into human microbiome, the origin of their constituent microbiota remains unclear. Dust (also known as particulate matter) is a key determinant of poor air quality in the modern urban environment. It is ubiquitous and serves as a major source and reservoir of microbial communities that modulates the human microbiome, contributing to health and disease. There are evidence that reported significant associations between environmental dust and NCDs. In this review, we will focus on the impact of dust exposure in shaping the human microbiome and its possible contribution to the development of NCDs.
Dust, microbiome, non-communicable diseases, particulate matter
2040-1744
545-556
Ooi, Delicia Shu-Qin
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Tan, Cheryl Pei-Ting
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Tay, Michelle Jia-Yu
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Ong, Siong Gim
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Tham, Elizabeth Huiwen
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Siah, Kewin Tien Ho
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Eriksson, Johan Gunnar
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Godfrey, Keith
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Shek, Lynette Pei-Chi
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Loo, Evelyn Xiu-Ling
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Ooi, Delicia Shu-Qin
bc619b7a-b844-43e4-8e78-9f93d99a3f4c
Tan, Cheryl Pei-Ting
f7b59747-60ef-4616-9499-7c5397a282ec
Tay, Michelle Jia-Yu
fc55c45c-2b24-4667-a6b8-6492e162a532
Ong, Siong Gim
55f5f524-297b-488b-9138-131c951608f9
Tham, Elizabeth Huiwen
e22014ec-8242-478a-aafc-e4177164f814
Siah, Kewin Tien Ho
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Eriksson, Johan Gunnar
eb96b1c5-af07-4a52-8a73-7541451d32cd
Godfrey, Keith
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Shek, Lynette Pei-Chi
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Loo, Evelyn Xiu-Ling
229ed4b9-220f-4d95-a384-eb6529f6d2d6

Ooi, Delicia Shu-Qin, Tan, Cheryl Pei-Ting, Tay, Michelle Jia-Yu, Ong, Siong Gim, Tham, Elizabeth Huiwen, Siah, Kewin Tien Ho, Eriksson, Johan Gunnar, Godfrey, Keith, Shek, Lynette Pei-Chi and Loo, Evelyn Xiu-Ling (2020) Developmental origins of health and disease: impact of environmental dust exposure in modulating microbiome and its association with non-communicable diseases. Journal of Developmental Origins of Health and Disease, 11 (6), 545-556. (doi:10.1017/S2040174420000549).

Record type: Article

Abstract

Non-communicable diseases (NCDs) including obesity, diabetes and allergy are chronic, multi-factorial conditions that are affected by both genetic and environmental factors. Over the last decade, the microbiome has emerged as a possible contributor to the pathogenesis of NCDs. Microbiome profiles were altered in patients with NCDs, and shift in microbial communities was associated with improvement in these health conditions. Since the genetic component of these diseases cannot be altered, the ability to manipulate the microbiome holds great promise for design of novel therapies in the prevention and treatment of NCDs. Together, the Developmental Origins of Health and Disease (DOHaD) concept and the microbial hypothesis propose that early life exposure to environmental stimuli will alter the development and composition of the human microbiome, resulting in health consequences. Recent studies indicated that the environment we are exposed to in early life is instrumental in shaping robust immune development, possibly through modulation of the human microbiome (skin, airway and gut). Despite much research into human microbiome, the origin of their constituent microbiota remains unclear. Dust (also known as particulate matter) is a key determinant of poor air quality in the modern urban environment. It is ubiquitous and serves as a major source and reservoir of microbial communities that modulates the human microbiome, contributing to health and disease. There are evidence that reported significant associations between environmental dust and NCDs. In this review, we will focus on the impact of dust exposure in shaping the human microbiome and its possible contribution to the development of NCDs.

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Dohad dust review final EL 060520 - Accepted Manuscript
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Accepted/In Press date: 8 May 2020
e-pub ahead of print date: 15 June 2020
Published date: 1 December 2020
Additional Information: Funding Information: KMG is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042), NIHR Southampton 1000DaysPlus Global Nutrition Research Group) and NIHR Southampton Biomedical Research Centre), the European Union (Erasmus+ Programme Early Nutrition eAcademy Southeast Asia-573651-EPP-1-2016-1-DE-EPPKA2-CBHE-JP), the US National Institute On Aging of the National Institutes of Health (Award No. U24AG047867), and the UK ESRC and BBSRC (Award No. ES/M00919X/1). Loo EX is supported by the Singapore National Medical Research Council (NMRC/OFYIRG/015/2016-00). Publisher Copyright: © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020.
Keywords: Dust, microbiome, non-communicable diseases, particulate matter

Identifiers

Local EPrints ID: 441515
URI: http://eprints.soton.ac.uk/id/eprint/441515
ISSN: 2040-1744
PURE UUID: 89e6ae64-8f1c-457a-b86e-9a1759b3b5b0
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 17 Jun 2020 16:30
Last modified: 17 Mar 2024 05:40

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Contributors

Author: Delicia Shu-Qin Ooi
Author: Cheryl Pei-Ting Tan
Author: Michelle Jia-Yu Tay
Author: Siong Gim Ong
Author: Elizabeth Huiwen Tham
Author: Kewin Tien Ho Siah
Author: Johan Gunnar Eriksson
Author: Keith Godfrey ORCID iD
Author: Lynette Pei-Chi Shek
Author: Evelyn Xiu-Ling Loo

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