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Optical microfibre based photonic components and their applications in label-free biosensing

Optical microfibre based photonic components and their applications in label-free biosensing
Optical microfibre based photonic components and their applications in label-free biosensing
Optical microfibre photonic components offer a variety of enabling properties, including large evanescent fields, flexibility, configurability, high confinement, robustness and compactness. These unique features have been exploited in a range of applications such as telecommunication, sensing, optical manipulation and high Q resonators. Optical microfibre biosensors, as a class of fibre optic biosensors which rely on small geometries to expose the evanescent field to interact with samples, have been widely investigated. Due to their unique properties, such as fast response, functionalization, strong confinement, configurability, flexibility, compact size, low cost, robustness, ease of miniaturization, large evanescent field and label-free operation, optical microfibres based biosensors seem a promising alternative to traditional immunological methods for biomolecule measurements. Unlabeled DNA and protein targets can be detected by monitoring the changes of various optical transduction mechanisms, such as refractive index, absorption and surface plasmon resonance, since a target molecule is capable of binding to an immobilized optical microfibre. In this review, we critically summarize accomplishments of past optical microfibre label-free biosensors, identify areas for future research and provide a detailed account of the studies conducted to date for biomolecules detection using optical microfibres.
0265-928X
471-499
Wang, P.
bfd1b87c-c776-4fa6-99f6-d72de76cc07d
Bo, L.
bc436773-eba1-438a-892d-c92f389967b9
Semenova, Y.
45267263-f4a6-47bd-b84d-768e9b0d2dfc
Farrell, G.
09f74789-4377-4964-a6da-793184ad8c13
Brambilla, G.
815d9712-62c7-47d1-8860-9451a363a6c8
Wang, P.
bfd1b87c-c776-4fa6-99f6-d72de76cc07d
Bo, L.
bc436773-eba1-438a-892d-c92f389967b9
Semenova, Y.
45267263-f4a6-47bd-b84d-768e9b0d2dfc
Farrell, G.
09f74789-4377-4964-a6da-793184ad8c13
Brambilla, G.
815d9712-62c7-47d1-8860-9451a363a6c8

Wang, P., Bo, L., Semenova, Y., Farrell, G. and Brambilla, G. (2015) Optical microfibre based photonic components and their applications in label-free biosensing. Biosensors, 5 (3), 471-499. (doi:10.3390/bios5030471).

Record type: Article

Abstract

Optical microfibre photonic components offer a variety of enabling properties, including large evanescent fields, flexibility, configurability, high confinement, robustness and compactness. These unique features have been exploited in a range of applications such as telecommunication, sensing, optical manipulation and high Q resonators. Optical microfibre biosensors, as a class of fibre optic biosensors which rely on small geometries to expose the evanescent field to interact with samples, have been widely investigated. Due to their unique properties, such as fast response, functionalization, strong confinement, configurability, flexibility, compact size, low cost, robustness, ease of miniaturization, large evanescent field and label-free operation, optical microfibres based biosensors seem a promising alternative to traditional immunological methods for biomolecule measurements. Unlabeled DNA and protein targets can be detected by monitoring the changes of various optical transduction mechanisms, such as refractive index, absorption and surface plasmon resonance, since a target molecule is capable of binding to an immobilized optical microfibre. In this review, we critically summarize accomplishments of past optical microfibre label-free biosensors, identify areas for future research and provide a detailed account of the studies conducted to date for biomolecules detection using optical microfibres.

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More information

Accepted/In Press date: 7 July 2015
Published date: 22 July 2015

Identifiers

Local EPrints ID: 441594
URI: http://eprints.soton.ac.uk/id/eprint/441594
ISSN: 0265-928X
PURE UUID: 41cd79b6-311f-4e96-8eb8-df57c87a5ce4
ORCID for G. Brambilla: ORCID iD orcid.org/0000-0002-5730-0499

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Date deposited: 18 Jun 2020 16:53
Last modified: 02 Apr 2022 01:38

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Contributors

Author: P. Wang
Author: L. Bo
Author: Y. Semenova
Author: G. Farrell
Author: G. Brambilla ORCID iD

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