Liver organoids: from basic research to therapeutic applications
Liver organoids: from basic research to therapeutic applications
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ. In this perspective we will review the advances in the liver organoid field, its limitations and potential for biomedical applications.
disease modelling,liver,organoid,personalised medicine
2228-2237
Prior, Nicole
27851f03-6041-4409-a15c-a2a164b883e0
Inacio, Patricia
7da27c1e-750c-43f7-a617-9198e1209de0
Huch, Meritxell
defdc21f-6ca2-4a97-ab38-436adce9d37c
12 July 2019
Prior, Nicole
27851f03-6041-4409-a15c-a2a164b883e0
Inacio, Patricia
7da27c1e-750c-43f7-a617-9198e1209de0
Huch, Meritxell
defdc21f-6ca2-4a97-ab38-436adce9d37c
Prior, Nicole, Inacio, Patricia and Huch, Meritxell
(2019)
Liver organoids: from basic research to therapeutic applications.
Gut, 68, .
(doi:10.1136/gutjnl-2019-319256).
Abstract
Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ. In this perspective we will review the advances in the liver organoid field, its limitations and potential for biomedical applications.
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Liver organoids
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Accepted/In Press date: 30 June 2019
Published date: 12 July 2019
Keywords:
disease modelling,liver,organoid,personalised medicine
Identifiers
Local EPrints ID: 441624
URI: http://eprints.soton.ac.uk/id/eprint/441624
ISSN: 1468-3288
PURE UUID: b8eab97f-0a44-481a-ab04-5efc3d27a290
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Date deposited: 22 Jun 2020 16:30
Last modified: 17 Mar 2024 04:02
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Author:
Patricia Inacio
Author:
Meritxell Huch
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