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Bactericidal effect of 5-mercapto-2-nitrobenzoic acid-coated silver nanoclusters against multidrug-resistant Neisseria gonorrhoeae

Bactericidal effect of 5-mercapto-2-nitrobenzoic acid-coated silver nanoclusters against multidrug-resistant Neisseria gonorrhoeae
Bactericidal effect of 5-mercapto-2-nitrobenzoic acid-coated silver nanoclusters against multidrug-resistant Neisseria gonorrhoeae

Neisseria gonorrhoeae is among the most multidrug-resistant bacteria in circulation today, and new treatments are urgently needed. In this work, we demonstrate the ability of 5-mercapto-2-nitrobenzoic acid-coated silver nanoclusters (MNBA-AgNCs) to kill strains of Neisseria gonorrhoeae. Using an in vitro bactericidal assay, MNBA-AgNCs had been found to show significantly higher anti-gonococcal bioactivity than the antibiotics ceftriaxone and azithromycin and silver nitrate. These nanoclusters were effective against both planktonic bacteria and a gonococcal infection of human cell cultures in vitro. Treatment of human cells in vitro with MNBA-AgNCs did not induce significant release of lactate dehydrogenase, suggesting minimal cytotoxicity to eukaryotic cells. Our results suggest that MNBA-AgNCs hold great potential for topical treatment of localized gonorrhoeae.

antibacterial properties, azithromycin, ceftriaxone, human cells, nanoparticles, Neisseria gonorrhoeae, silver nanoclusters
1944-8244
27994–28003
Lucío, María Isabel
496d5f14-3826-4ef1-9522-77b6b0cd988c
Kyriazi, Maria-Eleni
3cfe9662-4e7f-49bc-b707-ccc2b4da6b09
Hamilton, Joshua
09930fc3-07c1-464d-8aca-45c106fae3e7
Batista, Diego
0e67849b-da8e-4190-ac51-e6467018afcc
Sheppard, Alexander
bd1cf051-ee46-427f-857b-ef61ee587cdb
Sams-Dodd, Elisabeth
de640659-c6e7-4d83-b534-178315313b2e
Humbert, Maria Victoria
82134d25-24b8-4fdd-bd1c-461683b5322e
Hussain, Irshad
6fcf2f10-9969-4d33-9169-ca89845ef720
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Lucío, María Isabel
496d5f14-3826-4ef1-9522-77b6b0cd988c
Kyriazi, Maria-Eleni
3cfe9662-4e7f-49bc-b707-ccc2b4da6b09
Hamilton, Joshua
09930fc3-07c1-464d-8aca-45c106fae3e7
Batista, Diego
0e67849b-da8e-4190-ac51-e6467018afcc
Sheppard, Alexander
bd1cf051-ee46-427f-857b-ef61ee587cdb
Sams-Dodd, Elisabeth
de640659-c6e7-4d83-b534-178315313b2e
Humbert, Maria Victoria
82134d25-24b8-4fdd-bd1c-461683b5322e
Hussain, Irshad
6fcf2f10-9969-4d33-9169-ca89845ef720
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7

Lucío, María Isabel, Kyriazi, Maria-Eleni, Hamilton, Joshua, Batista, Diego, Sheppard, Alexander, Sams-Dodd, Elisabeth, Humbert, Maria Victoria, Hussain, Irshad, Christodoulides, Myron and Kanaras, Antonios G. (2020) Bactericidal effect of 5-mercapto-2-nitrobenzoic acid-coated silver nanoclusters against multidrug-resistant Neisseria gonorrhoeae. ACS Applied Materials and Interfaces, 12 (25), 27994–28003. (doi:10.1021/acsami.0c06163).

Record type: Article

Abstract

Neisseria gonorrhoeae is among the most multidrug-resistant bacteria in circulation today, and new treatments are urgently needed. In this work, we demonstrate the ability of 5-mercapto-2-nitrobenzoic acid-coated silver nanoclusters (MNBA-AgNCs) to kill strains of Neisseria gonorrhoeae. Using an in vitro bactericidal assay, MNBA-AgNCs had been found to show significantly higher anti-gonococcal bioactivity than the antibiotics ceftriaxone and azithromycin and silver nitrate. These nanoclusters were effective against both planktonic bacteria and a gonococcal infection of human cell cultures in vitro. Treatment of human cells in vitro with MNBA-AgNCs did not induce significant release of lactate dehydrogenase, suggesting minimal cytotoxicity to eukaryotic cells. Our results suggest that MNBA-AgNCs hold great potential for topical treatment of localized gonorrhoeae.

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Accepted/In Press date: 2 June 2020
e-pub ahead of print date: 12 June 2020
Published date: 24 June 2020
Keywords: antibacterial properties, azithromycin, ceftriaxone, human cells, nanoparticles, Neisseria gonorrhoeae, silver nanoclusters
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Identifiers

Local EPrints ID: 441799
URI: http://eprints.soton.ac.uk/id/eprint/441799
DOI: doi:10.1021/acsami.0c06163
ISSN: 1944-8244
PURE UUID: fef2e58c-f2d9-447b-b33c-7bca93fcdf49
ORCID for Maria Victoria Humbert: ORCID iD orcid.org/0000-0002-5728-6981
ORCID for Myron Christodoulides: ORCID iD orcid.org/0000-0002-9663-4731
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

Catalogue record

Date deposited: 26 Jun 2020 16:45
Last modified: 12 Nov 2024 05:01

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Contributors

Author: María Isabel Lucío
Author: Maria-Eleni Kyriazi
Author: Joshua Hamilton
Author: Diego Batista
Author: Alexander Sheppard
Author: Elisabeth Sams-Dodd
Author: Maria Victoria Humbert ORCID iD
Author: Irshad Hussain
Author: Myron Christodoulides ORCID iD
Author: Antonios G. Kanaras ORCID iD

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