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Research priorities in pediatric asthma: results of a global survey of multiple stakeholder groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

Research priorities in pediatric asthma: results of a global survey of multiple stakeholder groups by the Pediatric Asthma in Real Life (PeARL) Think Tank
Research priorities in pediatric asthma: results of a global survey of multiple stakeholder groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

BACKGROUND: Pediatric asthma remains a public health challenge with enormous impact worldwide.

OBJECTIVE: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities.

METHODS: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared.

RESULTS: A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best treatment by age group were priorities for responders from low-middle-income countries. There was good agreement across different stakeholder groups in all domains with some notable exceptions that highlight the importance of involving the whole range of stakeholders in formulation of recommendations.

CONCLUSIONS: Different stakeholders agree in the majority of research and strategic (eg, prevention, personalized approach) priorities for pediatric asthma. Stakeholder diversity is crucial for highlighting divergent issues that future guidelines should consider.

Assessment, Asthma, Childhood asthma, Clinical research, Diagnosis, Management, Pediatric asthma, Research priorities
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Mathioudakis, Alexander G.
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Matricardi, Paolo M.
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Miligkos, Michael
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Mathioudakis, Alexander G., Custovic, Adnan, Deschildre, Antoine, Ducharme, Francine M, Kalayci, Omer, Murray, Clare, Garcia, Antonio Nieto, Phipatanakul, Wanda, Price, David, Sheikh, Aziz, Agache, Ioana, Bacharier, Leonard, Bonini, Matteo, Castro-Rodriguez, Jose A., De Carlo, Giuseppe, Craig, Timothy, Diamant, Zuzana, Feleszko, Wojciech, Ierodiakonou, Despo, Gern, James E., Grigg, Jonathan, Hedlin, Gunilla, Hossny, Elham M, Jartti, Tuomas, Kaplan, Alan, Lemanske, Robert F., Le Souef, Peter, Makela, Mika J., Matricardi, Paolo M., Miligkos, Michael, Morais-Almeida, Mário, Pite, Helena, Pitrez, Paulo M C, Pohunek, Petr, Roberts, Graham, Sanchez-Garcia, Sylvia, Tsiligianni, Ioanna, Turner, Steve, Winders, Tonya A., Wong, Gary, Xepapadaki, Paraskevi, Zar, Heather J. and Papadopoulos, Nikolaos G. (2020) Research priorities in pediatric asthma: results of a global survey of multiple stakeholder groups by the Pediatric Asthma in Real Life (PeARL) Think Tank. The Journal of Allergy and Clinical immunology: In Practice, 8 (6), 1953-1960.e9. (doi:10.1016/j.jaip.2020.01.059).

Record type: Article

Abstract

BACKGROUND: Pediatric asthma remains a public health challenge with enormous impact worldwide.

OBJECTIVE: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities.

METHODS: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared.

RESULTS: A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best treatment by age group were priorities for responders from low-middle-income countries. There was good agreement across different stakeholder groups in all domains with some notable exceptions that highlight the importance of involving the whole range of stakeholders in formulation of recommendations.

CONCLUSIONS: Different stakeholders agree in the majority of research and strategic (eg, prevention, personalized approach) priorities for pediatric asthma. Stakeholder diversity is crucial for highlighting divergent issues that future guidelines should consider.

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More information

Accepted/In Press date: 31 January 2020
e-pub ahead of print date: 4 March 2020
Published date: June 2020
Keywords: Assessment, Asthma, Childhood asthma, Clinical research, Diagnosis, Management, Pediatric asthma, Research priorities

Identifiers

Local EPrints ID: 441831
URI: http://eprints.soton.ac.uk/id/eprint/441831
ISSN: 2213-2198
PURE UUID: 6b9b9f03-cf73-4c8f-912e-9ccaa2c3acd2
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 29 Jun 2020 16:33
Last modified: 02 Jul 2022 01:42

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Contributors

Author: Alexander G. Mathioudakis
Author: Adnan Custovic
Author: Antoine Deschildre
Author: Francine M Ducharme
Author: Omer Kalayci
Author: Clare Murray
Author: Antonio Nieto Garcia
Author: Wanda Phipatanakul
Author: David Price
Author: Aziz Sheikh
Author: Ioana Agache
Author: Leonard Bacharier
Author: Matteo Bonini
Author: Jose A. Castro-Rodriguez
Author: Giuseppe De Carlo
Author: Timothy Craig
Author: Zuzana Diamant
Author: Wojciech Feleszko
Author: Despo Ierodiakonou
Author: James E. Gern
Author: Jonathan Grigg
Author: Gunilla Hedlin
Author: Elham M Hossny
Author: Tuomas Jartti
Author: Alan Kaplan
Author: Robert F. Lemanske
Author: Peter Le Souef
Author: Mika J. Makela
Author: Paolo M. Matricardi
Author: Michael Miligkos
Author: Mário Morais-Almeida
Author: Helena Pite
Author: Paulo M C Pitrez
Author: Petr Pohunek
Author: Graham Roberts ORCID iD
Author: Sylvia Sanchez-Garcia
Author: Ioanna Tsiligianni
Author: Steve Turner
Author: Tonya A. Winders
Author: Gary Wong
Author: Paraskevi Xepapadaki
Author: Heather J. Zar
Author: Nikolaos G. Papadopoulos

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