The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age

Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age
Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age
Purpose: current literature on the roles of α-, β-carotene and β-cryptoxanthin in neurocognitive function has largely focused on preventing cognitive decline in older people, and less on neuro-development in children. We examined the relations of maternal plasma carotenoids concentrations with offspring cognitive development up to age 4.5 years in the Growing Up in Singapore Towards healthy Outcomes mother–offspring cohort study.

Methods: maternal plasma α-, β-carotene and β-cryptoxanthin concentrations at delivery were determined by ultra-performance liquid chromatography. Children’s cognition was assessed at ages 2 (Bayley Scales of Infant and Toddler Development) and 4.5 (Kaufman Brief Intelligence Test) years. Associations were examined in 419 mother–offspring pairs using linear regressions adjusting for key confounders.

Results: median and interquartile range of maternal plasma concentrations (mg/L) were: α-carotene 0.052 (0.032, 0.081), β-carotene 0.189 (0.134, 0.286), and β-cryptoxanthin 0.199 (0.123, 0.304). In 2 years old children, higher maternal carotenoids [per standard deviation (SD) log-concentration] were positively associated with neurocognitive functions: β-cryptoxanthin with higher scores in cognitive [β = 0.18, (0.08, 0.28) SD], receptive language [β = 0.17 (0.07, 0.27) SD], fine motor [β = 0.16 (0.05, 0.26) SD], and gross motor [β = 0.16 (0.06, 0.27) SD] scales; β-carotene with higher cognitive score [β = 0.17 (0.05, 0.29) SD]. No significant associations were observed with neurocognitive functions at age 4.5 years.

Conclusion: our study provides novel data suggesting a potential role of prenatal carotenoids, particularly β-cryptoxanthin, on early offspring cognitive and motor development. Whether the prenatal influences sustain beyond early childhood requires further investigation in longer term studies.
Carotenoids, Children, Cognition, Motor, Pregnancy
1436-6207
Lai, Jun S.
1fd69464-147f-4220-ab67-f9d76437cf3b
Cai, Shirong
6e4e2d93-9910-4fc8-91a1-07d445f868a4
Lee, Bee Lan
70d26f4c-f44d-4ac4-b13a-61cd1cdfc911
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Shek, Lynette P.
9a77403c-0e0c-4536-a5ad-628ce94b279a
Yap, Fabian
22f6b954-31fc-4696-a52b-e985a424b95b
Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Ong, Choon Nam
29ad2936-dbb8-45c6-8455-03abf5ca757a
Meaney, Michael J.
5c6db45a-1f5b-4e1f-8c0b-07a8f7b29f66
Rifkin-Graboi, Anne
af440bed-c49d-4417-93b3-2243c8a2f1a8
Broekman, Birit F.P.
c8933c70-c439-4676-9d4d-2c522f193589
Chong, Mary F.F.
7c540836-aa50-4fc4-81f8-36ff8e0c773c
Lai, Jun S.
1fd69464-147f-4220-ab67-f9d76437cf3b
Cai, Shirong
6e4e2d93-9910-4fc8-91a1-07d445f868a4
Lee, Bee Lan
70d26f4c-f44d-4ac4-b13a-61cd1cdfc911
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Shek, Lynette P.
9a77403c-0e0c-4536-a5ad-628ce94b279a
Yap, Fabian
22f6b954-31fc-4696-a52b-e985a424b95b
Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Ong, Choon Nam
29ad2936-dbb8-45c6-8455-03abf5ca757a
Meaney, Michael J.
5c6db45a-1f5b-4e1f-8c0b-07a8f7b29f66
Rifkin-Graboi, Anne
af440bed-c49d-4417-93b3-2243c8a2f1a8
Broekman, Birit F.P.
c8933c70-c439-4676-9d4d-2c522f193589
Chong, Mary F.F.
7c540836-aa50-4fc4-81f8-36ff8e0c773c

Lai, Jun S., Cai, Shirong, Lee, Bee Lan, Godfrey, Keith, Gluckman, Peter D., Shek, Lynette P., Yap, Fabian, Tan, Kok Hian, Chong, Yap-Seng, Ong, Choon Nam, Meaney, Michael J., Rifkin-Graboi, Anne, Broekman, Birit F.P. and Chong, Mary F.F. (2020) Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age. European Journal of Nutrition. (doi:10.1007/s00394-020-02277-2).

Record type: Article

Abstract

Purpose: current literature on the roles of α-, β-carotene and β-cryptoxanthin in neurocognitive function has largely focused on preventing cognitive decline in older people, and less on neuro-development in children. We examined the relations of maternal plasma carotenoids concentrations with offspring cognitive development up to age 4.5 years in the Growing Up in Singapore Towards healthy Outcomes mother–offspring cohort study.

Methods: maternal plasma α-, β-carotene and β-cryptoxanthin concentrations at delivery were determined by ultra-performance liquid chromatography. Children’s cognition was assessed at ages 2 (Bayley Scales of Infant and Toddler Development) and 4.5 (Kaufman Brief Intelligence Test) years. Associations were examined in 419 mother–offspring pairs using linear regressions adjusting for key confounders.

Results: median and interquartile range of maternal plasma concentrations (mg/L) were: α-carotene 0.052 (0.032, 0.081), β-carotene 0.189 (0.134, 0.286), and β-cryptoxanthin 0.199 (0.123, 0.304). In 2 years old children, higher maternal carotenoids [per standard deviation (SD) log-concentration] were positively associated with neurocognitive functions: β-cryptoxanthin with higher scores in cognitive [β = 0.18, (0.08, 0.28) SD], receptive language [β = 0.17 (0.07, 0.27) SD], fine motor [β = 0.16 (0.05, 0.26) SD], and gross motor [β = 0.16 (0.06, 0.27) SD] scales; β-carotene with higher cognitive score [β = 0.17 (0.05, 0.29) SD]. No significant associations were observed with neurocognitive functions at age 4.5 years.

Conclusion: our study provides novel data suggesting a potential role of prenatal carotenoids, particularly β-cryptoxanthin, on early offspring cognitive and motor development. Whether the prenatal influences sustain beyond early childhood requires further investigation in longer term studies.

Text
maternalcarotenoids_childcognition_ejon_revision - Accepted Manuscript
Download (158kB)
Text
ESM_1
Restricted to Repository staff only
Request a copy
Image
maternalcarotenoids_childcognition_fig1_final
Restricted to Repository staff only
Request a copy

More information

Accepted/In Press date: 11 May 2020
Published date: 20 May 2020
Keywords: Carotenoids, Children, Cognition, Motor, Pregnancy

Identifiers

Local EPrints ID: 441842
URI: http://eprints.soton.ac.uk/id/eprint/441842
ISSN: 1436-6207
PURE UUID: e1b714b1-b51b-4919-accc-2f08f40639a5
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 30 Jun 2020 16:30
Last modified: 26 Nov 2021 06:16

Export record

Altmetrics

Contributors

Author: Jun S. Lai
Author: Shirong Cai
Author: Bee Lan Lee
Author: Keith Godfrey ORCID iD
Author: Peter D. Gluckman
Author: Lynette P. Shek
Author: Fabian Yap
Author: Kok Hian Tan
Author: Yap-Seng Chong
Author: Choon Nam Ong
Author: Michael J. Meaney
Author: Anne Rifkin-Graboi
Author: Birit F.P. Broekman
Author: Mary F.F. Chong

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×