Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells

Poli, Alessandro, Fiume, Roberta, Mongiorgi, Sara, Zaurito, Antonio, Sheth, Bhavwanti, Vidalle, Magdalena Castellano, Hamid, Shidqiyyah Abdul, Kimber, Scottt., Campagnoli, Francesca, Ratti, Stefano, Rusciano, Isabella, Faenza, Irene, Manzoli, Lucia and Divecha, Nullin (2020) Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells. Advances in Biological Regulation, 76, 100722, [100722]. (doi:10.1016/j.jbior.2020.100722).

Abstract

The immune system is a complex network that acts to protect vertebrates from foreign microorganisms and carries out immunosurveillance to combat cancer. In order to avoid hyper-activation of the immune system leading to collateral damage tissues and organs and to prevent self-attack, the network has the intrinsic control mechanisms that negatively regulate immune responses. Central to this negative regulation are regulatory T (T-Reg) cells, which through cytokine secretion and cell interaction limit uncontrolled clonal expansion and functions of activated immune cells. Given that positive or negative manipulation of T-Regs activity could be utilised to therapeutically treat host versus graft rejection or cancer respectively, understanding how signaling pathways impact on T-Regs function should reveal potential targets with which to intervene.

The phosphatidylinositol-3-kinase (PI3K) pathway controls a vast array of cellular processes and is critical in T cell activation. Here we focus on phosphoinositide 3-kinases (PI3Ks) and their ability to regulate T-Regs cell differentiation and function.

This record has no associated files available for download.

Contributors

Download statistics