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Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells

Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells
Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells
The immune system is a complex network that acts to protect vertebrates from foreign microorganisms and carries out immunosurveillance to combat cancer. In order to avoid hyper-activation of the immune system leading to collateral damage tissues and organs and to prevent self-attack, the network has the intrinsic control mechanisms that negatively regulate immune responses. Central to this negative regulation are regulatory T (T-Reg) cells, which through cytokine secretion and cell interaction limit uncontrolled clonal expansion and functions of activated immune cells. Given that positive or negative manipulation of T-Regs activity could be utilised to therapeutically treat host versus graft rejection or cancer respectively, understanding how signaling pathways impact on T-Regs function should reveal potential targets with which to intervene.

The phosphatidylinositol-3-kinase (PI3K) pathway controls a vast array of cellular processes and is critical in T cell activation. Here we focus on phosphoinositide 3-kinases (PI3Ks) and their ability to regulate T-Regs cell differentiation and function.
2212-4926
Poli, Alessandro
e856efa4-09b7-41fc-a169-0a1f9eb9bdab
Fiume, Roberta
ed01a587-2ca6-480d-baa3-cc221a6830ae
Mongiorgi, Sara
781e3fb8-3bd4-4529-8d46-b33445eaf5f3
Zaurito, Antonio
37f44011-f29d-4942-a117-b49486dac6e0
Sheth, Bhavwanti
2ca6ed58-a992-47b7-b3a5-3c5df82aada7
Vidalle, Magdalena Castellano
f4377882-86de-451e-bff4-837e6b0cafb8
Hamid, Shidqiyyah Abdul
7703bfce-0078-46ee-a33e-d467fbdca319
Kimber, Scottt.
6738027e-3580-4088-ac24-747542e12328
Campagnoli, Francesca
62cc4f73-7429-44cd-a59c-935d616b7397
Ratti, Stefano
5da664ba-8e8a-437a-a944-ec8590bc1726
Rusciano, Isabella
bec8a9ba-2ecd-4977-89cd-9441748dc0dd
Faenza, Irene
65f048ad-fb3f-4cc5-b4cd-cfc18f9454fd
Manzoli, Lucia
da89b10a-0752-431d-85ac-7bcba3a16470
Divecha, Nullin
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
Poli, Alessandro
e856efa4-09b7-41fc-a169-0a1f9eb9bdab
Fiume, Roberta
ed01a587-2ca6-480d-baa3-cc221a6830ae
Mongiorgi, Sara
781e3fb8-3bd4-4529-8d46-b33445eaf5f3
Zaurito, Antonio
37f44011-f29d-4942-a117-b49486dac6e0
Sheth, Bhavwanti
2ca6ed58-a992-47b7-b3a5-3c5df82aada7
Vidalle, Magdalena Castellano
f4377882-86de-451e-bff4-837e6b0cafb8
Hamid, Shidqiyyah Abdul
7703bfce-0078-46ee-a33e-d467fbdca319
Kimber, Scottt.
6738027e-3580-4088-ac24-747542e12328
Campagnoli, Francesca
62cc4f73-7429-44cd-a59c-935d616b7397
Ratti, Stefano
5da664ba-8e8a-437a-a944-ec8590bc1726
Rusciano, Isabella
bec8a9ba-2ecd-4977-89cd-9441748dc0dd
Faenza, Irene
65f048ad-fb3f-4cc5-b4cd-cfc18f9454fd
Manzoli, Lucia
da89b10a-0752-431d-85ac-7bcba3a16470
Divecha, Nullin
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787

Poli, Alessandro, Fiume, Roberta, Mongiorgi, Sara, Zaurito, Antonio, Sheth, Bhavwanti, Vidalle, Magdalena Castellano, Hamid, Shidqiyyah Abdul, Kimber, Scottt., Campagnoli, Francesca, Ratti, Stefano, Rusciano, Isabella, Faenza, Irene, Manzoli, Lucia and Divecha, Nullin (2020) Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells. Advances in Biological Regulation, 76, [100722]. (doi:10.1016/j.jbior.2020.100722).

Record type: Article

Abstract

The immune system is a complex network that acts to protect vertebrates from foreign microorganisms and carries out immunosurveillance to combat cancer. In order to avoid hyper-activation of the immune system leading to collateral damage tissues and organs and to prevent self-attack, the network has the intrinsic control mechanisms that negatively regulate immune responses. Central to this negative regulation are regulatory T (T-Reg) cells, which through cytokine secretion and cell interaction limit uncontrolled clonal expansion and functions of activated immune cells. Given that positive or negative manipulation of T-Regs activity could be utilised to therapeutically treat host versus graft rejection or cancer respectively, understanding how signaling pathways impact on T-Regs function should reveal potential targets with which to intervene.

The phosphatidylinositol-3-kinase (PI3K) pathway controls a vast array of cellular processes and is critical in T cell activation. Here we focus on phosphoinositide 3-kinases (PI3Ks) and their ability to regulate T-Regs cell differentiation and function.

Full text not available from this repository.

More information

Accepted/In Press date: 16 April 2020
e-pub ahead of print date: 23 April 2020
Published date: 1 May 2020

Identifiers

Local EPrints ID: 441892
URI: http://eprints.soton.ac.uk/id/eprint/441892
ISSN: 2212-4926
PURE UUID: ad15ac5a-9fc0-427b-a126-929bdd1223ac

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Date deposited: 01 Jul 2020 16:35
Last modified: 06 Oct 2020 20:19

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Contributors

Author: Alessandro Poli
Author: Roberta Fiume
Author: Sara Mongiorgi
Author: Antonio Zaurito
Author: Bhavwanti Sheth
Author: Magdalena Castellano Vidalle
Author: Scottt. Kimber
Author: Francesca Campagnoli
Author: Stefano Ratti
Author: Isabella Rusciano
Author: Irene Faenza
Author: Lucia Manzoli
Author: Nullin Divecha

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