Menstrual symptoms and risk of preterm birth: a population-based longitudinal study
Menstrual symptoms and risk of preterm birth: a population-based longitudinal study
Objectives: To examine the prospective association between menstrual symptoms before pregnancy and preterm birth. Methods: Secondary analysis of data from 14 247 young Australian women born between 1973 and 1978 who participated in a longitudinal, population-based cohort study between 1996 and 2015. Women were first surveyed at 18-23 years, and seven waves of data were collected at roughly three-yearly intervals. At each survey, women were asked about “severe period pain,” “heavy periods,” and “irregular periods” within the last 12 months. From 2009 onward, information on their children was collected, including birth dates and preterm birth (<37 weeks). Logistic regression using generalized estimating equations was used to examine prospective associations between self-reported menstrual symptoms before pregnancy and risk of preterm birth. Results: Data from 6615 mothers who had 12 337 live singleton births were available for analysis. Among all births, women reporting severe period pain (adjusted odds ratio [aOR] 1.34 [95% CI 1.10-1.62]) or heavy periods (1.25 [1.02-1.53]) before pregnancy had higher odds of preterm birth. However, in analyses stratified by birth order, only severe period pain (2.05 [1.41-2.99]), heavy periods (1.77 [1.23-2.55]), or irregular periods (1.58 [1.10-2.28]) before a second or subsequent birth were associated with an increased risk of preterm birth. Conclusions: Severe period pain, heavy periods, and irregular periods before a second or subsequent birth may be associated with preterm birth.
cohort study, dysmenorrhea, heavy menstrual bleeding, irregular periods, preterm birth
270-277
Rowlands, Ingrid J.
05815cd2-b30b-4539-87e3-765b62a452ef
Aye, San Kyu Kyu
33fa45e3-90ed-414d-9614-e5370ccd4a5d
Schoenaker, Danielle A.J.M.
84b96b87-4070-45a5-9777-5a1e4e45e818
Dobson, Annette J.
e0837e7f-6bcd-4709-8706-899ae2cff1b2
Mishra, Gita D.
02143b82-e536-4915-9b30-3c86cbe1a1fe
1 September 2020
Rowlands, Ingrid J.
05815cd2-b30b-4539-87e3-765b62a452ef
Aye, San Kyu Kyu
33fa45e3-90ed-414d-9614-e5370ccd4a5d
Schoenaker, Danielle A.J.M.
84b96b87-4070-45a5-9777-5a1e4e45e818
Dobson, Annette J.
e0837e7f-6bcd-4709-8706-899ae2cff1b2
Mishra, Gita D.
02143b82-e536-4915-9b30-3c86cbe1a1fe
Rowlands, Ingrid J., Aye, San Kyu Kyu, Schoenaker, Danielle A.J.M., Dobson, Annette J. and Mishra, Gita D.
(2020)
Menstrual symptoms and risk of preterm birth: a population-based longitudinal study.
Birth, 47 (3), .
(doi:10.1111/birt.12493).
Abstract
Objectives: To examine the prospective association between menstrual symptoms before pregnancy and preterm birth. Methods: Secondary analysis of data from 14 247 young Australian women born between 1973 and 1978 who participated in a longitudinal, population-based cohort study between 1996 and 2015. Women were first surveyed at 18-23 years, and seven waves of data were collected at roughly three-yearly intervals. At each survey, women were asked about “severe period pain,” “heavy periods,” and “irregular periods” within the last 12 months. From 2009 onward, information on their children was collected, including birth dates and preterm birth (<37 weeks). Logistic regression using generalized estimating equations was used to examine prospective associations between self-reported menstrual symptoms before pregnancy and risk of preterm birth. Results: Data from 6615 mothers who had 12 337 live singleton births were available for analysis. Among all births, women reporting severe period pain (adjusted odds ratio [aOR] 1.34 [95% CI 1.10-1.62]) or heavy periods (1.25 [1.02-1.53]) before pregnancy had higher odds of preterm birth. However, in analyses stratified by birth order, only severe period pain (2.05 [1.41-2.99]), heavy periods (1.77 [1.23-2.55]), or irregular periods (1.58 [1.10-2.28]) before a second or subsequent birth were associated with an increased risk of preterm birth. Conclusions: Severe period pain, heavy periods, and irregular periods before a second or subsequent birth may be associated with preterm birth.
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Menstrual-symptoms-and-PTB-BIRTH-accepted manuscript
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More information
Accepted/In Press date: 18 May 2020
e-pub ahead of print date: 5 June 2020
Published date: 1 September 2020
Additional Information:
Funding Information:
IJR was supported by an Australian National Health and Medical Research Council Centre for Research Excellence (grant number: APP1000986). GDM is funded by an Australian National Health and Medical Research Council Principal Research Fellowship (APP1121844). The Australian Longitudinal Study on Women's Health is funded by the Australian Government Department of Health. The research on which this paper is based was conducted as part of the Australian Longitudinal Study on Women's Health, the University of Newcastle, and the University of Queensland. We are grateful to the Australian Government Department of Health for funding and to the women who provided the survey data.
Publisher Copyright:
© 2020 Wiley Periodicals LLC
Keywords:
cohort study, dysmenorrhea, heavy menstrual bleeding, irregular periods, preterm birth
Identifiers
Local EPrints ID: 441995
URI: http://eprints.soton.ac.uk/id/eprint/441995
ISSN: 0730-7659
PURE UUID: 268310ec-4d07-4442-829e-116347fb7e02
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Date deposited: 03 Jul 2020 16:31
Last modified: 17 Mar 2024 05:40
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Contributors
Author:
Ingrid J. Rowlands
Author:
San Kyu Kyu Aye
Author:
Annette J. Dobson
Author:
Gita D. Mishra
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