Successful treatment of chronic myelomonocytic leukaemia with hydroxycarbamide in a patient presenting with acute hypoxic respiratory failure due to COVID‐19 pneumonia

Abstract

On 30th March 2020, a 57-year-old male patient presented to the Emergency Department with a 6-day history of cough, persistent fevers and worsening dyspnoea. His only known comorbidity was hypertension, managed with amlodipine and an angiotensin converting enzyme inhibitor. On admission, he was tachypnoeic and in severe hypoxic respiratory failure with dangerously low peripheral oxygen saturations (SpO2) 83% on 15L oxygen. Chest radiographic changes were consistent with COVID-19 infection and demonstrated bilateral changes with diffuse airspace shadowing with more confluence in the lower zones (Figure 1A). Other relevant investigations included haemoglobin of 127 g/L, white blood cell count (WCC) of 117.4 x109/L, neutrophil count 32.8 x109/L, basophils 0.4 x109/L, lymphocytes 2.7 x109/L, monocytes 56.1 x109/L, platelet count 116 x109/L, C-reactive protein 54 mg/L, lactic acid dehydrogenase 1732 U/L and D- Dimer 664 ng/ml.

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ORCID for Andrew Cumpstey: orcid.org/0000-0001-6257-207X

ORCID for Felino Cagampang: orcid.org/0000-0003-4404-9853

ORCID for Ahilanandan Dushianthan: orcid.org/0000-0002-0165-3359

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