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Successful treatment of chronic myelomonocytic leukaemia with hydroxycarbamide in a patient presenting with acute hypoxic respiratory failure due to COVID‐19 pneumonia

Successful treatment of chronic myelomonocytic leukaemia with hydroxycarbamide in a patient presenting with acute hypoxic respiratory failure due to COVID‐19 pneumonia
Successful treatment of chronic myelomonocytic leukaemia with hydroxycarbamide in a patient presenting with acute hypoxic respiratory failure due to COVID‐19 pneumonia
On 30th March 2020, a 57-year-old male patient presented to the Emergency Department with a 6-day history of cough, persistent fevers and worsening dyspnoea. His only known comorbidity was hypertension, managed with amlodipine and an angiotensin converting enzyme inhibitor. On admission, he was tachypnoeic and in severe hypoxic respiratory failure with dangerously low peripheral oxygen saturations (SpO2) 83% on 15L oxygen. Chest radiographic changes were consistent with COVID-19 infection and demonstrated bilateral changes with diffuse airspace shadowing with more confluence in the lower zones (Figure 1A). Other relevant investigations included haemoglobin of 127 g/L, white blood cell count (WCC) of 117.4 x109/L, neutrophil count 32.8 x109/L, basophils 0.4 x109/L, lymphocytes 2.7 x109/L, monocytes 56.1 x109/L, platelet count 116 x109/L, C-reactive protein 54 mg/L, lactic acid dehydrogenase 1732 U/L and D- Dimer 664 ng/ml.
COVID-19, chronic myelomonocytic leukaemia, respiratory failure
0007-1048
e195-e198
Chopra, J.
20f72605-aecc-425c-999d-6a4346e5d400
Hiew, H.J.
e271ec99-0376-4eb4-b2c9-852c8fb3d6af
Cumpstey, Andrew
050a389c-f550-4453-a80a-f1a6e57db923
Cagampang, Felino
7cf57d52-4a65-4554-8306-ed65226bc50e
Jenner, Matthew W.
cd3d756c-4c87-4551-8177-4451680fef72
Dushianthan, Ahilanandan
013692a2-cf26-4278-80bd-9d8fcdb17751
Chopra, J.
20f72605-aecc-425c-999d-6a4346e5d400
Hiew, H.J.
e271ec99-0376-4eb4-b2c9-852c8fb3d6af
Cumpstey, Andrew
050a389c-f550-4453-a80a-f1a6e57db923
Cagampang, Felino
7cf57d52-4a65-4554-8306-ed65226bc50e
Jenner, Matthew W.
cd3d756c-4c87-4551-8177-4451680fef72
Dushianthan, Ahilanandan
013692a2-cf26-4278-80bd-9d8fcdb17751

Chopra, J., Hiew, H.J., Cumpstey, Andrew, Cagampang, Felino, Jenner, Matthew W. and Dushianthan, Ahilanandan (2020) Successful treatment of chronic myelomonocytic leukaemia with hydroxycarbamide in a patient presenting with acute hypoxic respiratory failure due to COVID‐19 pneumonia. British Journal of Haematology, 190 (4), e195-e198, [BJH16978]. (doi:10.1111/bjh.16978).

Record type: Letter

Abstract

On 30th March 2020, a 57-year-old male patient presented to the Emergency Department with a 6-day history of cough, persistent fevers and worsening dyspnoea. His only known comorbidity was hypertension, managed with amlodipine and an angiotensin converting enzyme inhibitor. On admission, he was tachypnoeic and in severe hypoxic respiratory failure with dangerously low peripheral oxygen saturations (SpO2) 83% on 15L oxygen. Chest radiographic changes were consistent with COVID-19 infection and demonstrated bilateral changes with diffuse airspace shadowing with more confluence in the lower zones (Figure 1A). Other relevant investigations included haemoglobin of 127 g/L, white blood cell count (WCC) of 117.4 x109/L, neutrophil count 32.8 x109/L, basophils 0.4 x109/L, lymphocytes 2.7 x109/L, monocytes 56.1 x109/L, platelet count 116 x109/L, C-reactive protein 54 mg/L, lactic acid dehydrogenase 1732 U/L and D- Dimer 664 ng/ml.

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bjh.16978 - Accepted Manuscript
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Accepted/In Press date: 25 June 2020
e-pub ahead of print date: 27 June 2020
Published date: 1 August 2020
Keywords: COVID-19, chronic myelomonocytic leukaemia, respiratory failure

Identifiers

Local EPrints ID: 442029
URI: http://eprints.soton.ac.uk/id/eprint/442029
ISSN: 0007-1048
PURE UUID: 72e00f12-b0af-4f81-aeea-b71f4c17965e
ORCID for Andrew Cumpstey: ORCID iD orcid.org/0000-0001-6257-207X
ORCID for Felino Cagampang: ORCID iD orcid.org/0000-0003-4404-9853
ORCID for Ahilanandan Dushianthan: ORCID iD orcid.org/0000-0002-0165-3359

Catalogue record

Date deposited: 06 Jul 2020 16:30
Last modified: 28 Apr 2022 02:28

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Contributors

Author: J. Chopra
Author: H.J. Hiew
Author: Andrew Cumpstey ORCID iD
Author: Matthew W. Jenner
Author: Ahilanandan Dushianthan ORCID iD

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