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Antipsychotic drugs and diabetes: an application of the Austin Bradford Hill criteria

Holt, R.I. and Peveler, R.C. (2006) Antipsychotic drugs and diabetes: an application of the Austin Bradford Hill criteria Diabetologia, 49, (7), pp. 1467-1476. (doi:10.1007/s00125-006-0279-3).

Record type: Article


There is concern that antipsychotic drugs cause diabetes. Although there has been an explosion in the quantity of literature about this subject, it remains confusing and inconsistent. To assess whether the association between antipsychotic drugs and diabetes is causative, we applied the Austin Bradford Hill criteria to the available evidence. In support of a causative relationship, there is temporality for some cases of diabetes, and there is a biologically plausible explanation. The causative link between antipsychotic drugs and diabetes is coherent with our understanding of diabetes and there are other analogies. However the strength of association is weak, there is lack of consistency or specificity, and there is little evidence to support a biological gradient. We should therefore conclude that the evidence surrounding a causative link between antipsychotic drugs and diabetes is inconclusive. Moreover, the risk is probably low and the attributable risk of developing diabetes is greater for traditional risk factors such as family history, ethnicity, obesity and ageing than it is for receiving an antipsychotic drug. Consequently, the majority of patients receiving second-generation antipsychotics will not develop diabetes as a result of their medication.

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Published date: 2006
Keywords: ageing, models, complications, drug therapy, disease, diabetic neuropathies, endocrinology, theoretical, risk factors, health, adverse effects, humans, obesity, diabetes mellitus, diabetes, origins, developmental origins, chemically induced, etiology, review, metabolism, risk, schizophrenia, antipsychotic agents
Organisations: Clinical Neurosciences


Local EPrints ID: 44204
ISSN: 0012-186X
PURE UUID: f3688ea6-eb2e-4b06-9db2-ab484c910d98
ORCID for R.I. Holt: ORCID iD
ORCID for R.C. Peveler: ORCID iD

Catalogue record

Date deposited: 20 Feb 2007
Last modified: 17 Jul 2017 15:15

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