Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities

Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Furthermore, this review will provide the reader with an update on the clinical aspects of CSC including risk factors, diagnostic challenges and findings from multimodal imaging.

Central serous chorioretinopathy (CSC), Choroid, Choroidal endothelial cells (CECs), Complement factor H (CFH), Corticosteroids, Eplerenone, Hyperpermeability, Mineralocorticoids, Pachychoroid, Retinal pigment epithelium (RPE)

10.1016/j.preteyeres.2020.100865

1350-9462

1-31

Kaye, Rebecca

5736c211-ec31-441c-ac72-db1191ca935c

Chandra, Shruti

fa761820-c45c-4eea-a84e-356ddf788e99

Sheth, Jay

b1da83b4-1e40-4ce6-b4be-6ef42b3f6476

Boon, Camiel

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Sivaprasad, Sobha

7cd590d6-18f0-4ae1-8ace-4b35833c2f03

Lotery, Andrew

5ecc2d2d-d0b4-468f-ad2c-df7156f8e514

November 2020

Kaye, Rebecca

5736c211-ec31-441c-ac72-db1191ca935c

Chandra, Shruti

fa761820-c45c-4eea-a84e-356ddf788e99

Sheth, Jay

b1da83b4-1e40-4ce6-b4be-6ef42b3f6476

Boon, Camiel

291d8ae0-dbcf-4593-b9b3-e69c9bbcf0ef

Sivaprasad, Sobha

7cd590d6-18f0-4ae1-8ace-4b35833c2f03

Lotery, Andrew

5ecc2d2d-d0b4-468f-ad2c-df7156f8e514

Kaye, Rebecca, Chandra, Shruti, Sheth, Jay, Boon, Camiel, Sivaprasad, Sobha and Lotery, Andrew (2020) Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities. Progress in Retinal and Eye Research, 79, 1-31, [100865]. (doi:10.1016/j.preteyeres.2020.100865).

Record type: Article

Abstract

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CSCR Review for PRER - Accepted Manuscript

Available under License Creative Commons Attribution Non-commercial No Derivatives.

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Accepted/In Press date: 27 April 2020

e-pub ahead of print date: 11 May 2020

Published date: November 2020

Additional Information: Funding Information: The Gift of Sight Charity Appeal. The research was supported by the NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology.Grant support for AL was provided by an NIHR senior investigator award.SS and SC are funded by the GCRF UKRI (MR/P207881/1). Funding Information: This work was supported by The Gift of Sight Charity Appeal at the University of Southampton and by the NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology. Publisher Copyright: © 2020 Elsevier Ltd

Keywords: Central serous chorioretinopathy (CSC), Choroid, Choroidal endothelial cells (CECs), Complement factor H (CFH), Corticosteroids, Eplerenone, Hyperpermeability, Mineralocorticoids, Pachychoroid, Retinal pigment epithelium (RPE)