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Severity of retinopathy of prematurity was associated with a higher risk of cerebral dysfunction in young adults born extremely preterm

Severity of retinopathy of prematurity was associated with a higher risk of cerebral dysfunction in young adults born extremely preterm
Severity of retinopathy of prematurity was associated with a higher risk of cerebral dysfunction in young adults born extremely preterm
Aim: This Swedish study evaluated whether the severity of retinopathy of prematurity (ROP) in extremely preterm infants was related to their overall outcome in young adulthood.

Methods: We followed 39 individuals born 1988-93 at less than 28 gestational weeks, included in the Stockholm Neonatal Project. 19 were treated for severe ROP and 20 had no or mild ROP. They were assessed for general cognitive abilities and mental health at 18 years of age and compared with 23 term-born controls. Visual acuity was examined at 21-25 years. They were asked about their education and everyday life.

Results: The 19 individuals with severe, treated ROP had lower visual acuity and higher risk for intellectual deficits, cerebral palsy, and neuropsychiatric diagnoses than those with no or mild ROP and the term controls. Three were visually impaired, none were blind. They were less physically active than the other groups and had more problems finding their way around. However, nine were at university.

Conclusion: Young adults treated for severe ROP had more problems resulting from cerebral dysfunction than those with no or mild ROP and term-born controls. Retinal and brain pathologies in the extremely preterm infant constitute different expressions of neurovascular disease.
adult outcome, cerebral dysfunction, cognition, cryo-treatment, retinopathy of prematurity
0803-5253
Jacobsson, Lena
df24c7e3-dfbd-4ede-bf50-cd3c4c4f9de3
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Kistner, Anna
53da233f-ca17-43a2-80d8-19ec88c31713
Bohm, Birgitta
455f8a0f-d086-439c-82b0-b156f90ef47d
Jacobsson, Lena
df24c7e3-dfbd-4ede-bf50-cd3c4c4f9de3
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Kistner, Anna
53da233f-ca17-43a2-80d8-19ec88c31713
Bohm, Birgitta
455f8a0f-d086-439c-82b0-b156f90ef47d

Jacobsson, Lena, Vollmer, Brigitte, Kistner, Anna and Bohm, Birgitta (2020) Severity of retinopathy of prematurity was associated with a higher risk of cerebral dysfunction in young adults born extremely preterm. Acta Paediatrica, International Journal of Paediatrics. (doi:10.1111/apa.15461).

Record type: Article

Abstract

Aim: This Swedish study evaluated whether the severity of retinopathy of prematurity (ROP) in extremely preterm infants was related to their overall outcome in young adulthood.

Methods: We followed 39 individuals born 1988-93 at less than 28 gestational weeks, included in the Stockholm Neonatal Project. 19 were treated for severe ROP and 20 had no or mild ROP. They were assessed for general cognitive abilities and mental health at 18 years of age and compared with 23 term-born controls. Visual acuity was examined at 21-25 years. They were asked about their education and everyday life.

Results: The 19 individuals with severe, treated ROP had lower visual acuity and higher risk for intellectual deficits, cerebral palsy, and neuropsychiatric diagnoses than those with no or mild ROP and the term controls. Three were visually impaired, none were blind. They were less physically active than the other groups and had more problems finding their way around. However, nine were at university.

Conclusion: Young adults treated for severe ROP had more problems resulting from cerebral dysfunction than those with no or mild ROP and term-born controls. Retinal and brain pathologies in the extremely preterm infant constitute different expressions of neurovascular disease.

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ROP_Paper - Accepted Manuscript
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More information

Accepted/In Press date: 29 June 2020
e-pub ahead of print date: 6 July 2020
Keywords: adult outcome, cerebral dysfunction, cognition, cryo-treatment, retinopathy of prematurity

Identifiers

Local EPrints ID: 442279
URI: http://eprints.soton.ac.uk/id/eprint/442279
ISSN: 0803-5253
PURE UUID: ed34fd40-bb6b-4192-8380-49bf3b46b37b
ORCID for Brigitte Vollmer: ORCID iD orcid.org/0000-0003-4088-5336

Catalogue record

Date deposited: 10 Jul 2020 16:31
Last modified: 26 Nov 2021 05:18

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Contributors

Author: Lena Jacobsson
Author: Anna Kistner
Author: Birgitta Bohm

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