Chapter 15. Singlet-assisted diffusion NMR

Tourell, Monique and Pileio, Giuseppe (2020) Chapter 15. Singlet-assisted diffusion NMR. In, Pileio, Giuseppe (ed.) Long-lived Nuclear Spin Order: Theory and Applications. (New Developments in NMR) London. Royal Society of Chemistry, pp. 280-301. (doi:10.1039/9781788019972-00280).

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Abstract

The incorporation of long-lived singlet states into diffusion-NMR experiments allows the translational motion of molecules to be observed over many minutes. This is a significant improvement of the observation times available in traditional NMR techniques, and allows for measurements of large macromolecules with slow diffusion coefficients and restricted diffusion in macroporous systems. This chapter introduces the methodology for singlet-assisted diffusion-NMR (SAD-NMR), a method that uses nearly-equivalent spin-1/2 pairs to store spatially encoded magnetization in long-lived singlet states for up to ten minutes. The potential for this method to characterize the morphological properties of macroporous media is demonstrated, and future “real-world” applications are discussed.

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Published date: 15 April 2020

Additional Information: Funding Information: Authors work presented in this chapter was provided by EPSRC grant EP/N033558/1. The authors thank Prof. Mia Woodruff, Dr Sean Powell and Mr Max McLaughlin of the Biofabrication and Tissue Morphology Group, Queensland University of Technology, Brisbane, Australia for preparation of the seeded tissue engineered constructs. Publisher Copyright: © The Royal Society of Chemistry 2020.